BetaSys

1. Systems Biology of the β-Cell – Revisited
Flemming Pociot

2. Established Facts and Open Questions of Regulated Exocytosis in β-Cells – A Background for a Focused Systems Analysis Approach
Erik Renström

3. Mitochondria and Metabolic Signals in β-Cells
Pierre Maechler

4. β-Cell Ontogenesis and the Insulin Production Apparatus
R. Scott Heller, Ole D. Madsen

5. The Role of the Cytoskeleton in Transport and Release of Insulin-Containing Granules by Pancreatic β-Cells
Roger S. Goody, Hans Georg Mannherz

6. The Mathematical Microscope – Making the Inaccessible Accessible
Johnny T. Ottesen

7. Magnetic Resonance Imaging of Pancreatic β-Cells
Patrick F. Antkowiak, Raghavendra G. Mirmira, Frederick H. Epstein

8. Mapping the β-Cell in 3D at the Nanoscale Using Novel Cellular Electron Tomography and Computational Approaches
Andrew B. Noske, Brad J. Marsh

9. In Vivo Applications of Inorganic Nanoparticles
Joseph Bear, Gaëlle Charron, María Teresa Fernández-Argüelles, Salam Massadeh, Paul McNaughter, Thomas Nann

10. Cell Cultivation and Sensor-Based Assays for Dynamic Measurements of Cell Vitality
Angela M. Otto

11. Bioimpedance Spectroscopy
Beate Klösgen, Christine Rümenapp, Bernhard Gleich

12. DNA Variations, Impaired Insulin Secretion and Type 2 Diabetes
Valeriya Lyssenko, Leif Groop

13. Genetically Programmed Defects in β-Cell Function
Aparna Pal, Anna L. Gloyn

14.
Proteomic AnalysisProteomic analysis
of the Pancreatic Islet β-Cellpancreatic islet β-cell

Secretory Granulesecretory granule
: Current Understanding and Future Opportunities
Garth J. S. Cooper

15. Physiological and Pathophysiological Role of Islet Amyloidislet amyloid
Polypeptide
islet amyloid polypeptide
(IAPPIAPP
, Amylinamylin
)
Gunilla T. Westermark

16. Present State of Islet Transplantation for Type 1 Diabetes Patients
Torbjörn Lundgren, Olle Korsgren

17. Predictive Protein Networks and Identification of Druggable Targets in the β-Cell
Joachim Størling, Regine Bergholdt

18. Nanotoxicity
Gary R. Hutchison, Eva M. Malone

19. From Silicon Cellsilicon cell
to Silicon Humansilicon human


Hans V. Westerhoff, Malkhey Verma, Frank J. Bruggeman, Alexey Kolodkin, Maciej Swat, Neil Hayes, Maria Nardelli, Barbara M. Bakker, Jacky L. Snoep

20. Probing Cellular Dynamics with Mesoscopic Simulations
Julian Shillcock

21. What Drives Calcium Oscillations in β-Cells? New Tasks for Cyclic Analysis
Leonid E. Fridlyand, Louis H. Philipson

22. Whole-Body and Cellular Models of Glucose-Stimulated Insulin Secretion
Gianna Maria Toffolo, Morten Gram Pedersen, Claudio Cobelli

23. Geometric and Electromagnetic Aspects of Fusion Pore Making
Darya Apushkinskaya, Evgeny Apushkinsky, Bernhelm Booß-Bavnbek, Martin Koch

Keywords: Life Sciences, Systems Biology, Human Genetics, Bioinformatics, Diabetes