The Tumor Microenvironment

1. Combination Strategies Targeting Hypoxia Inducible Factor 1 (HIF-1) for Cancer Therapy
Annamaria Rapisarda, Giovanni Melillo

2. The Tumor Microenvironment: New Insights into Regulation of Tumor pH by Carbonic Anhydrases
Pawel Swietach, Adrian L. Harris, Richard D. Vaughan-Jones

3. Hypoxia, Gene Expression, and Metastasis
Olga V. Razorenova, Amato J. Giaccia

4. Molecular Mechanisms Regulating Expression and Function of Cancer-Associated Carbonic Anhydrase IX
Jaromir Pastorek, Silvia Pastorekova

5. Glycolytic Pathway as a Target for Tumor Inhibition
Weiqin Lu, Peng Huang

6. Aberrant DNA Methylation in Cancer Cells
Toshikazu Ushijima

7. DNA Repair and Redox Signaling
Mark R. Kelley, Millie M. Georgiadis, Melissa L. Fishel

8. Cancer Stem Cells and Microenvironment
Mario Federico, Antonio Giordano

9. Epithelial–Mesenchymal Transition in Development and Diseases
Yadi Wu, Binhua P. Zhou

10. Invasion and Metastasis
Douglas M. Noonan, Giuseppina Pennesi, Adriana Albini

11. Dormancy of Disseminated Tumor Cells: Reciprocal Crosstalk with the Microenvironment
Paloma Bragado, Aparna C. Ranganathan, Julio A. Aguirre-Ghiso

12. Impact of Endothelial Progenitor Cells on Tumor Angiogenesis and Outcome of Antiangiogenic Therapy: New Perspectives on an Ongoing Controversy
Robert S. Kerbel, Francesco Bertolini, Yuval Shaked

13. Bone Marrow Derived Mesenchymal Stem/Stromal Cells and Tumor Growth
Pravin J. Mishra, Debabrata Banerjee

14. Integrin Signaling in Lymphangiogenesis
Barbara Garmy-Susini

15. Role of Pericytes in Resistance to Antiangiogenic Therapy
Koji Matsuo, Chunhua Lu, Mian M. K. Shazad, Robert L. Coleman, Anil K. Sood

16. Tumour-Promoting Stromal Myofibroblasts in Human Carcinomas
Urszula M. Polanska, Kieran T. Mellody, Akira Orimo

17. Mast Cells and Tumor Microenvironment
Theoharis C. Theoharides, Konstantinos-Dionysios Alysandratos, Asimenia Angelidou, Bodi Zhang

18. Macrophages in the Tumor Microenvironment
Monica Escorcio-Correia, Thorsten Hagemann

19. The Prognostic Significance of Tumor-Infiltrating Lymphocytes
Ping Yu, Yang-Xin Fu

20. The Pro-inflammatory Milieu and Its Role in Malignant Epithelial Initiation
Adam Yagui-Beltrán, Qizhi Tang, David M. Jablons

21. Natural Killer Cells for Adoptive Immunotherapy
Jonathan E. Benjamin, Sally Arai

22. Fibronectin
Andreas Menrad

23. Collagen in Cancer
Janelle L. Lauer, Gregg B. Fields

24. Integrins and Cancer
Laurie G. Hudson, M. Sharon Stack

25. Matrix Metalloproteinases and Cancer Cell Invasion/Metastasis
Stanley Zucker, Jian Cao

26. Tetraspanins and Cancer Metastasis
Margot Zöller

27. Chemokines and Metastasis
Kalyan C. Nannuru, Seema Singh, Rakesh K. Singh

28. Transforming Growth Factor-β in Lung Cancer, Carcinogenesis, and Metastasis
Sonia B. Jakowlew

29. Cooperative Interactions Between Integrins and Growth Factor Signaling in Pathological Angiogenesis
Jennifer Roth, Eric Tweedie, Peter C. Brooks

30. The Extracellular Matrix and the Growth and Survival of Tumors
Yves A. DeClerck

31. Secreted Growth Factors as Therapeutic Targets
Beverly A. Teicher

32. Adrenomedullin
Rebecca G. Bagley

Keywords: Biomedicine, Cancer Research, Pharmacology/Toxicology