Wallach, David

Advances in TNF Family Research

Wallach, David - Advances in TNF Family Research, ebook


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Table of contents

1. Workshop Summary: Roles of the TNF Family in Normal Development and Cancer

Nancy H. Ruddle

2. TNF Conference 2009: Beyond Bones – RANKL/RANK in the Immune System
Andreas Leibbrandt, Josef M. Penninger

3. The Edar Subfamily in Hair and Exocrine Gland Development
Marja L. Mikkola

4. High Endothelial Venule Reporter Mice to Probe Regulation of Lymph Node Vasculature
Kevin L. Bentley, Sharon Stranford, Shan Liao, Rawad M. Mounzer, Frank H. Ruddle, Nancy H. Ruddle

5. Eiger and Wengen: The Drosophila Orthologs of TNF/TNFR
Tatsushi Igaki, Hiroshi Kanda, Hideyuki Okano, Tian Xu, Masayuki Miura

6. Workshop Summary: Novel Aspects of the Functions of the TRAFs and cIAPs

John Silke, Domagoj Vucic

7. TRAF2 and Cellular IAPs: A Critical Link in TNFR Family Signaling
Domagoj Vucic

8. New Perspectives in TNF-R1-Induced NF-κB Signaling
Ian E. Gentle, John Silke

9. Structural Studies of NEMO and TRAF6: Implications in NF-κB Activation
Hao Wu, Yu-Chih Lo, Qian Yin

10. Modification by Single Ubiquitin Moieties Rather Than Polyubiquitination Is Sufficient for Proteasomal Processing of the p105 NF-κB Precursor
Yelena Kravtsova-Ivantsiv, Shai Cohen, Aaron Ciechanover

11. Selective Binding of Linear Ubiquitin Chains to NEMO in NF-kappaB Activation
Fumiyo Ikeda, Simin Rahighi, Soichi Wakatsuki, Ivan Dikic

12. The Linear Ubiquitin Chain Assembly Complex (LUBAC) Forms Part of the TNF-R1 Signalling Complex and Is Required for Effective TNF-Induced Gene Induction and Prevents TNF-Induced Apoptosis
Christoph H. Emmerich, Anna C. Schmukle, Tobias L. Haas, Björn Gerlach, Stefanie M. Cordier, Eva Rieser, Henning Walczak

13. Temporal Control of TNFα Signaling by Miz1
Anning Lin

14. Large-Scale RNAi Screens to Dissect TNF and NF-κB Signaling Pathways
Marie Metzig, Dorothee Nickles, Michael Boutros

15. Pathogenic Role of IL-6 Combined with TNF-α or IL-1 in the Induction of Acute Phase Proteins SAA and CRP in Chronic Inflammatory Diseases
Kazuyuki Yoshizaki

16. Understanding Life and Death at CD95
Carina Pforr, Leo Neumann, Roland Eils, Peter H. Krammer, Inna N. Lavrik

17. Unique Personalities Within the NF-κB Family: Distinct Functions for p65 and RelB in the Osteoclast
Deborah Veis Novack

18. Workshop Summary: Functions of the TNF Family in Infectious Disease
Michael Wortzman, Tania H. Watts

19. Role of 4-1BBL and TRAF1 in the CD8 T Cell Response to Influenza Virus and HIV
Tania H. Watts, Gloria H.Y. Lin, Chao Wang, Ann J. McPherson, Laura M. Snell, Laurent Sabbagh

20. Roles of Soluble and Membrane TNF and Related Ligands in Mycobacterial Infections: Effects of Selective and Non-selective TNF Inhibitors During Infection
Irene Garcia, Maria L. Olleros, Valerie F.J. Quesniaux, Muazzam Jacobs, Nasiema Allie, Sergei A. Nedospasov, David E. Szymkowski, Bernhard Ryffel

21. Poxviral TNFRs: Properties and Role in Viral Pathogenesis
Alí Alejo, Sergio M. Pontejo, Antonio Alcami

22. Heme Sensitization to TNF-Mediated Programmed Cell Death
Raffaella Gozzelino, Miguel P. Soares

23. TNF-α and TNFR in Chagas Disease: From Protective Immunity to Pathogenesis of Chronic Cardiomyopathy
Joseli Lannes-Vieira, Isabela Resende Pereira, Nathália Ferreira Vinagre, Lucia Elena Alvarado Arnez

24. Lymphotoxin’s Link to Carcinogenesis: Friend or Foe? From Lymphoid Neogenesis to Hepatocellular Carcinoma and Prostate Cancer
Monika Julia Wolf, Gitta Maria Seleznik, Mathias Heikenwalder

25. Anti-inflammatory Functions of Caspase-8
Akhil Rajput, Tae-Bong Kang, Konstantin Bogdanov, Jin-Chul Kim, Tehila Ben-Moshe, Andrew Kovalenko, David Wallach

26. Endogenous Ligand-Induced Activation of TLR4 in Pre-metastatic Phase Is Both Downstream and Upstream of TNF Signaling
Yoshiro Maru

27. Introductory Words About TL1A/DR3
Stephan R. Targan

28. Introductory Words About TWEAK/Fn14
Linda C. Burkly

29. Insights into TL1A and IBD Pathogenesis
David Q. Shih, Kathrin S. Michelsen, Robert J. Barrett, Eva Biener-Ramanujan, Rivkah Gonsky, Xiaolan Zhang, Stephan R. Targan

30. The Role of TNFRSF25:TNFSF15 in Disease… and Health?
Taylor H. Schreiber, Dietlinde Wolf, Eckhard R. Podack

31. Identification of New Candidates as Mucosal Vaccine Adjuvant in TNF Family Cytokines
Hiroyuki Kayamuro, Yasuo Yoshioka, Yasuhiro Abe, Kazufumi Katayama, Shuhei Arita, Tetsuya Nomura, Tomoaki Yoshikawa, Norio Itoh, Haruhiko Kamada, Shin-ichi Tsunoda, Yasuo Tsutsumi

32. The TWEAK/Fn14 Pathway in Tissue Remodeling: For Better or for Worse
Linda C. Burkly, Taeko Dohi

33. TWEAK and the Kidney: the Dual Role of a Multifunctional Cytokine
Ana Ortiz, M.D. Sanchez-Niño, M.C. Izquierdo, L.M. Blanco-Colio, R. Selgas, M. Ruiz-Ortega, J. Egido, Ana B. Sanz

34. TWEAK and TNF Regulation of Sclerostin: A Novel Pathway for the Regulation of Bone Remodelling
David M. Findlay, Gerald J. Atkins

35. Workshop Summary: Control of Lymphocyte Function and Repertoire by the TNF Superfamily
Carl F. Ware, Jeffrey L. Browning

36. The Canonical and Unconventional Ligands of the Herpesvirus Entry Mediator
Timothy C. Cheung, Carl F. Ware

37. The Lymphotoxin Pathway as a Novel Regulator of Dendritic Cell Function
Leslie Summers deLuca, Jennifer L. Gommerman

38. Involvement of the Cytokine Receptor CD137 in Murine Hematopoiesis
Dongsheng Jiang, Qianqiao Tang, Herbert Schwarz

39. LTBR-Pathway in Sjogren’s Syndrome: CXCL13 Levels and B-cell-Enriched Ectopic Lymphoid Aggregates in NOD Mouse Lacrimal Glands Are Dependent on LTBR
Roy A. Fava, Jeffrey L. Browning, Margaret Gatumu, Kathrine Skarstein, Anne-Isine Bolstad

40. MEK Kinase 1: Kinase Domain Deficiency in Mice Reveals a Role in Orchestrating the Thymus-Dependent Immunity and TNFR Family Signaling
Ewen Gallagher

41. Introduction to the Session “Mechanisms of Pathological and Therapeutic Effects of the TNF Family”
Claude Libert

42. Mechanisms Regulating TNF-Driven Gut and Joint Inflammation
Dirk Elewaut, Peggy Jacques, Lode Melis, Koen Venken

43. Lessons from Anti-TNF Biologics: Infliximab Failure in a TRAPS Family with the T50M Mutation in TNFRSF1A

Belinda Nedjai, Niamh Quillinan, Robert J. Coughlan, Leigh Church, Michael F. McDermott, Graham A. Hitman, Mark D. Turner

44. Modalities of Experimental TNF Blockade In Vivo: Mouse Models
A.A. Kruglov, A.V. Tumanov, S.I. Grivennikov, Yu.V. Shebzukhov, A.A. Kuchmiy, G.A. Efimov, M.S. Drutskaya, J. Scheller, D.V. Kuprash, Sergei A. Nedospasov

45. Tumor Necrosis Factor-α Signaling via TNFR1/p55 Is Deleterious Whereas TNFR2/p75 Signaling Is Protective in Adult Infarct Myocardium
Raj Kishore, Tengiz Tkebuchava, Sharath P. Sasi, Marcy Silver, Hu-Ya Gilbert, Young-Sup Yoon, Hee-Young Park, Tina Thorne, Douglas W. Losordo, David A. Goukassian

46. TNF-α Regulation of CD38 Expression in Human Airway Smooth Muscle: Role of MAP Kinases and NF-κB
Joseph A. Jude, Reynold A. Panettieri, Timothy F. Walseth, Mathur S. Kannan

47. Functional Consequences of Disease-Associated Mutations in TNFR1 Elucidated by Transcriptome Analysis
Susana L. Rebelo, Paul M. Radford, Susan E. Bainbridge, Ian Todd, Patrick J. Tighe

48. Tumor Necrosis Factor-α and Kidney Function: Experimental Findings in Mice
Dewan S.A. Majid

49. Strategies to Inhibit the Toxicity of Systemic TNF Treatment
Filip Hauwermeiren, Leen Puimège, Sofie Vandevyver, Tom Bogaert, Ineke Vanlaere, Liesbeth Huys, Lien Dejager, Claude Libert

50. Workshop Summary: Introduction to Rational Design of New Means for Therapeutic Modulation of Function of the TNF Family
Klaus Pfizenmaier, David E. Szymkowski

51. Anti-inflammatory Effects of a Novel TNFR1-Selective Antagonistic TNF Mutant on Established Murine Collagen-Induced Arthritis
Yasuhiro Abe, Tetsuya Nomura, Yasuo Yoshioka, Haruhiko Kamada, Shin-ichi Tsunoda, Yasuo Tsutsumi

52. A Proliferation-Inducing Ligand (APRIL): The Development of Antagonistic Agents as Potential Therapeutics and Deciphering the Role of Heparan Sulphate Proteoglycans (HSPGs) in APRIL Signalling
Fiona Kimberley, Marco Guadagnoli, Hans Eenennaam, Jan Paul Medema

53. Genetic Engineering of Death Ligands for Improvement of Therapeutic Activity
Jeannette Gerspach, Britta Schneider, Nicole Müller, Tina Otz, Harald Wajant, Klaus Pfizenmaier

54. Computational Design of TNF Ligand-Based Protein Therapeutics
Almer M. Sloot, Wim J. Quax

55. Workshop Summary: Roles of the TNF Family in Neuronal Development, Function and Pathology
Malú G. Tansey, Tony Wyss-Coray

56. TNF: A Key Neuroinflammatory Mediator of Neurotoxicity and Neurodegeneration in Models of Parkinson’s Disease
Melissa K. McCoy, Kelly A. Ruhn, Armin Blesch, Malú G. Tansey

57. The Contribution of TNFα to Synaptic Plasticity and Nervous System Function
David Stellwagen

58. Intracellular and Intercellular Cross Talk Between NGF and TNF
Yoshinori Takei, Ronald Laskey

59. TNFR2 – Target for Therapeutics Against Neurodegenerative Diseases?
Ingrid M. Nijholt, Ivica Granic, Paul G.M. Luiten, Ulrich L.M. Eisel

60. A Role for Neuronal NF-κB in Suppressing Neuroinflammation and Promoting Neuroprotection in the CNS
Mary Emmanouil, Era Taoufik, Vivian Tseveleki, Sotiris-Spyros Vamvakas, Lesley Probert

61. Workshop Summary: Cell Death Mechanisms Controlled by the TNF Family
John E. Eriksson, Peter Vandenabeele

62. A RNA Interference Screen Identifies RIP3 as an Essential Inducer of TNF-Induced Programmed Necrosis
YoungSik Cho, Sreerupa Challa, Francis Ka-Ming Chan

63. The Extracellular Matrix Protein CCN1 Dictates TNFα and FasL Cytotoxicity In Vivo
Chih-Chiun Chen, Vladislava Juric, Lester F. Lau

64. Compartmentalization of TNF-Receptor 1 Signaling: TNF-R1-Associated Caspase-8 Mediates Activation of Acid Sphingomyelinase in Late Endosomes
Uwe Bertsch, Bärbel Edelmann, Vladimir Tchikov, Supandi Winoto-Morbach, Stefan Schütze

65. TNF/TNF Receptor 1-Mediated Apoptosis in Hepatocytes
Hyun-Ae Eum, Timothy R. Billiar

66. Regulation of Cell Death by c-FLIP Phosphorylation
Tomoko Asaoka, Aura Kaunisto, John E. Eriksson

Keywords: Biomedicine, Immunology, Microbiology, Biomedicine general

Publication year
Advances in Experimental Medicine and Biology
Page amount
36 pages
Medicine, Health Care, Mode

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