Inflammation and Retinal Disease: Complement Biology and Pathology

1. The Case for Complement and Inflammation in AMD: Open Questions
Natalia Karagianni, Anthony P. Adamis

2. The Role of Complement in AMD
Peter F. Zipfel, Nadine Lauer, Christine Skerka

3. Multiple Interactions of Complement Factor H with Its Ligands in Solution: A Progress Report
Stephen J. Perkins, Ruodan Nan, Azubuike I. Okemefuna, Keying Li, Sanaullah Khan, Ami Miller

4. Genetic Control of Complement Activation in Humans and Age Related Macular Degeneration
Laura A. Hecker, Albert O. Edwards

5. Bisretinoids of RPE Lipofuscin: Trigger for Complement Activation in Age-Related Macular Degeneration
Janet R. Sparrow

6. The Role of the Classical Complement Cascade in Synapse Loss During Development and Glaucoma
Allison M. Rosen, Beth Stevens

7. A Role for Complement in Glaucoma?
Lizhen Ren, John Danias

8. The ATP-Binding Cassette Transporter ABCA4: Structural and Functional Properties and Role in Retinal Disease
Yaroslav Tsybovsky, Robert S. Molday, Krzysztof Palczewski

9. Suppression of Drusen Formation by Compstatin, a Peptide Inhibitor of Complement C3 activation, on Cynomolgus Monkey with Early-Onset Macular Degeneration
Zai-Long Chi, Tsunehiko Yoshida, John D. Lambris, Takeshi Iwata

10. A Targeted Inhibitor of the Complement Alternative Pathway Reduces RPE Injury and Angiogenesis in Models of Age-Related Macular Degeneration
Bärbel Rohrer, Qin Long, Beth Coughlin, Brandon Renner, Yuxiang Huang, Kannan Kunchithapautham, Viviana P. Ferreira, Michael K. Pangburn, Gary S. Gilkeson, Joshua M. Thurman, Stephen Tomlinson, V. Michael Holers

11. Complement Depletion with Humanized Cobra Venom Factor in a Mouse Model of Age-Related Macular Degeneration
David C. Fritzinger, Robin Dean, Carol Meschter, Katina Wong, Roman Halter, Jürgen Borlak, William D. St. John, Carl-Wilhelm Vogel

Keywords: Medicine & Public Health, Ophthalmology