The Principles of Clinical Cytogenetics

Part I. Basic Concepts and Background

1. History of Clinical Cytogenetics
Steven L. Gersen

2. DNA, Chromosomes, and Cell Division
Martha B. Keagle

3. Human Chromosome Nomenclature: An Overview and Definition of Terms
Marilyn L. Slovak, Aaron Theisen, Lisa G. Shaffer

Part II. Examining and Analyzing Chromosomes

4. Basic Cytogenetics Laboratory Procedures
Martha B. Keagle, Steven L. Gersen

5. The Essentials of Light Microscopy
Nathan S. Claxton, Stephen T. Ross

6. Quality Control and Quality Assurance
Martha B. Keagle

7. Instrumentation in the Cytogenetics Laboratory
Steven L. Gersen

Part III. Clinical Cytogenetics

8. Autosomal Aneuploidy
Jin-Chen C. Wang

9. Structural Chromosome Rearrangements
Kathleen Kaiser-Rogers, Kathleen W. Rao

10. Sex Chromosomes, Sex Chromosome Disorders, and Disorders of Sex Development
Cynthia M. Powell

11. The Cytogenetics of Infertility
Linda Marie Randolph

12. Prenatal Cytogenetics
Linda Marie Randolph

13. The Cytogenetics of Spontaneous Abortion
Solveig M. V. Pflueger

14. Chromosome Instability
Xiao-Xiang Zhang

Part IV. Cancer Cytogenetics

15. The Cytogenetics of Hematologic Neoplasms
Aurelia Meloni-Ehrig

16. The Cytogenetics of Solid Tumors
Linda D. Cooley, Kathleen S. Wilson

Part V. Adjunct Technologies

17. Fluorescence In Situ Hybridization (FISH)
Daynna J. Wolff

18. Microarray-Based Cytogenetics
Lisa G. Shaffer

Part VI. Beyond Chromosomes

19. Fragile X—A Family of Disorders: Changing Phenotype and Molecular Genetics
Elaine B. Spector

20. Genomic Imprinting and Uniparental Disomy
Jin-Chen C. Wang

21. Genetic Counseling
Sarah Hutchings Clark

Keywords: Biomedicine, Cytogenetics, Human Genetics, Pathology, Hematology, Oncology