Lipid A in Cancer Therapy

1. Introduction: Historical Background
Jean-Françcois Jeannin

2. Structure andSynthesis of Lipid A
Shoichi Kusumoto, Masahito Hashimoto, Kazuyoshi Kawahara

3. Conformation and Supramolecular Structure of Lipid A
Klaus Brandenburg, Ulrich Seydel

4. Interactions between Lipid A and Serum Proteins
Jörg Andrä, Thomas Gutsmann, Mareike Müller, Andra B. Schromm

5. The Lipid A Receptor
Kiyoshi Takeda

6. Lipid A Receptor TLR4-Mediated Signaling Pathways
Masahiro Yamamoto, Shizuo Akira

7. Lipid A-Induced Responses In Vivo
Néjia Sassi, Catherine Paul, Amandine Martin, Ali Bettaieb, Jean-François Jeannin

8. Lipid A-Mediated Tolerance and Cancer Therapy
Cheryl E. Rockwell, David. C. Morrison, Nilofer Qureshi

9. Lipid A in Cancer Therapies Preclinical Results
Daniele Reisser, Jean-François Jeannin

10. Monophosphoryl Lipid A (MPL) as an Adjuvant for Anti-Cancer Vaccines: Clinical Results
Christopher W. Cluff

11. Antitumoral Effects of Lipids A, Clinical Studies
Marc Bardou, Danièle Reisser

12. Conclusion
Jean-François Jeannin

Keywords: Biomedicine, Biomedicine general