Cancer Genome and Tumor Microenvironment

1. Hardwiring Tumor Progression
Andrei Thomas-Tikhonenko

2. PI3K/AKT Pathway and the Epithelial–Mesenchymal Transition
A. Bellacosa, L. Larue

3. Loss of Cadherin–Catenin Adhesion System in Invasive Cancer Cells
Wen-Hui Lien, Valeri Vasioukhin

4. Rho GTPases in Regulation of Cancer Cell Motility, Invasion, and Microenvironment
Donita C. Brady, Jamie K. Alan, Adrienne D. Cox

5. Merlin/NF2 Tumor Suppressor and Ezrin–Radixin–Moesin (ERM) Proteins in Cancer Development and Progression
L. Ren, C. Khanna

6. von Hippel–Lindau Tumor Suppressor, Hypoxia-Inducible Factor-1, and Tumor Vascularization
Huafeng Zhang, Gregg L. Semenza

7.
RAS Oncogenes and Tumor–Vascular Interface
Janusz Rak

8. Myc and Control of Tumor Neovascularization
Prema Sundaram, Chi V. Dang, Andrei Thomas-Tikhonenko

9. p53 and Angiogenesis
Jose G. Teodoro, Sara K. Evans, Michael R. Green

10. Ink4a Locus: Beyond Cell Cycle
Greg H. Enders

11. Nm23 as a Metastasis Inhibitor
Rajeev Kaul, Masanao Murakami, Pankaj Kumar, Erle S. Robertson

12. HGF/c-MET Signaling in Advanced Cancers
Mandira Ray, J G Garcia, Ravi Salgia

13. Contribution of ADAMs and ADAMTSs to Tumor Expansion and Metastasis
Antoni Xavier Torres-Collado, M. Luisa Iruela-Arispe

14. Stromal Cells and Tumor Milieu: PDGF et al.
Michele Jacob, Ellen Puré

15. TGF-β Signaling Alterations in Neoplastic and Stromal Cells
Qinghua Zeng, Boris Pasche

16. Genetic Instability and Chronic Inflammation in Gastrointestinal Cancers
Antonia R. Sepulveda, John P. Lynch

17. Immunoglobulin Gene Rearrangements, Oncogenic Translocations, B-Cell Receptor Signaling, and B Lymphomagenesis
Murali Gururajan, Subbarao Bondada

18. Modulation of Philadelphia Chromosome-Positive Hematological Malignancies by the Bone Marrow Microenvironment
Lin Wang, Heather O’Leary, Laura F. Gibson

19. Melanoma: Mutations in Multiple Pathways at the Tumor–Stroma Interface
Himabindu Gaddipati, Meenhard Herlyn

20. Cooperation and Cancer
Kathleen Sprouffske, Carlo C. Maley

Keywords: Biomedicine, Cancer Research, Oncology