Franceschi, Claudio

Handbook on Immunosenescence

Franceschi, Claudio - Handbook on Immunosenescence, ebook


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ISBN: 9781402090639
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Table of contents

Part I. Methods and Models for Studying Immunosenescence

1. The Immune Risk Profile and Associated Parameters in Late Life: Lessons from the OCTO and NONA Longitudinal Studies
Anders Wikby, Jan Strindhall, Boo Johansson

2. Lymphocytes Sub-Types and Functions in Centenarians as Models for Successful Ageing
Enrico Lugli, Leonarda Troiano, Marcello Pinti, Milena Nasi, Erika Roat, Roberta Ferraresi, Linda Bertoncelli, Lara Gibellini, Elisa Nemes, Andrea Cossarizza

3. Mouse Models and Genetics of Immunosenescence
Qing Yu, Jyoti Misra Sen, Dennis Taub

4. Insect Models of Immunosenescence
Jeff Leips

5. Clonal Culture Models of T-cell Senescence
Graham Pawelec, Jürgen Kempf, Anis Larbi

6. Mouse Models of Influenza
Ian C. Brett, Bert E. Johansson

7. A Transgenic Dwarf Rat Strain as a Tool for the Study of Immunosenescence in Aging Rats and the Effect of Calorie Restriction
Isao Shimokawa, Masanori Utsuyama, Toshimitsu Komatsu, Haruyoshi Yamaza, Takuya Chiba

8. Mathematical Modeling of Immunosenescence: Scenarios, Processes and Limitations
A. A. Romanyukha, S. G. Rudnev, T. A. Sannikova, A. I. Yashin

Part II. Cellular Immunosenescene - T Cells

9. Age, T-cell Homeostasis, and T-cell Diversity in Humans
David L Lamar, Cornelia M. Weyand, Jörg J. Goronzy

10. The Role of T-regulatory Cells in Immune Senescence
Paul Moss

11. Age-related Changes in Subpopulations of Peripheral Blood Lymphocytes in Healthy Japanese Population
Masanori Utsuyama, Yuko Kikuchi, Masanobu Kitagawa, Katsuiku Hirokawa

12. Age-associated T-cell Clonal Expansions (TCE) in vivo—Implications for Pathogen Resistance
Janko Nikolich-Žugich, Anna Lang

13. T-cell Cycle and Immunosenescence: Role of Aging in the T-cell Proliferative Behaviour and Status Quo Maintenance
Jacek M. Witkowski

14. Mismatch Repair System and Aging: Microsatellite Instability in Peripheral Blood Cells of the Elderly and in the T-cell Clone Longitudinal Model
Simona Neri, Erminia Mariani

15. Activation-Induced Cell Death of T-Cells in Elderly
Ewa Sikora, Agnieszka Brzezi?ska

16. CD8 Clonal Expansions in Mice: An Age-associated Alteration of CD8 Memory T-cells
Eric T. Clambey, John W. Kappler, Philippa Marrack

17. Generation and Gene Expression of CD28-CD8 T-cells in Human
Nan-ping Weng

18. Role of Regulatory Subsets During Aging
Piotr Trzonkowski

19. Transcription Factors in Mature B-Cells During Aging
Daniela Frasca, Richard L. Riley, Bonnie B. Blomberg

20. B-Cell Repertoire Changes in Mouse Models of Aging
Jean L. Scholz, William J. Quinn, Michael P. Cancro

21. B-Cells and Antibodies in Old Humans
Kate L. Gibson, Deborah K. Dunn-Walters

22. Neutrophil Granulocyte Functions in the Elderly
Peter Uciechowski, Lothar Rink

23. Signal Transduction Changes in fMLP, TLRs, TREM-1 and GM-CSF Receptors in PMN with Aging
Carl F. Fortin, Anis Larbi, Gilles Dupuis, Tamas Fulop

24. Synergistic Effects of Ageing and Stress on Neutrophil Function
Janet M. Lord, Anna C. Phillips, Wiebke Arlt

25. Role of Dendritic Cells in Aging
Anshu Agrawal, Sudhanshu Agrawal, Sudhir Gupta

26. Phenotypic and Functional Changes of Circulating Monocytes in Elderly
Lia Ginaldi, Massimo Martinis

27. NK Cells in Human Ageing
Raquel Tarazona, Inmaculada Gayoso, Corona Alonso, Corona Alonso, Esther Peralbo, Javier G. Casado, Beatriz Sánchez-Correa, Sara Morgado, Rafael Solana

28. Natural Killer Cells and Human Longevity
Hideto Tamura, Kiyoyuki Ogata

29. The Effects of Age on CD1d-restricted NKT-cells and Their Contribution to Peripheral T-cell Immunity
Douglas E. Faunce, Jessica L. Palmer

30. Lympho-Hematopoietic Stem Cells and Their Aging
Hartmut Geiger, Gary Zant

31. Implications of Developmental Switches for Hematopoietic Stem Cell Aging
Jens M. Nygren, David Bryder

32. Associations of Cytokine Polymorphisms with Immunosenescence
Elissaveta Naumova, Milena Ivanova

33. Cytokine Polymorphisms and Immunosenescence
Owen A. Ross, Kelly M. Hinkle, I. Maeve Rea

34. Role of TLR Polymorphisms in Immunosenescence
Carmela Balistreri, Giuseppina Candore, Giuseppina Colonna-Romano, Maria Grimaldi, Domenico Lio, Florinda Listì, Sonya Vasto, Letizia Scola, Calogero Caruso

Part III. Mechanisms - Receptors and Signal Transduction

35. Signal Transduction Changes in T-cells with Aging
Tamas Fulop, Gilles Dupuis, Carl Fortin, Anis Larbi

36. Molecular Signaling of CD95- and TNFR-Mediatedapoptosis in Naïve and Various Memory Subsets of T-Cells
Sudhir Gupta, Ankmalika Gupta

37. Mitochondria and Immunosenescence
Pazit Beckerman, Arie Yehuda

38. Proteasome Activity and Immunosenescence
Bertrand Friguet

39. Age-Related Changes in Type 1 and Type 2 Cytokine Production in Humans
Elizabeth M. Gardner, Donna M. Murasko

40. Cytokine Expression and Production Changes in Very Old Age
Susan E. McNerlan, Marilyn Armstrong, Owen A. Ross, I. Rea

41. Neuro-Endocrine-Immune Network and its Age-Related Changes
K. Hirokawa, M. Utsuyama

42. Sex Hormones and Immunosenescence
Christian R. Gomez, Vanessa Nomellini, Elizabeth J. Kovacs

43. Glucocorticoids and DHEA: Do They Have a Role in Immunosenescence?
Moisés E. Bauer, Cristina M. Moriguchi Jeckel, Cristina Bonorino, Flávia Ribeiro, Clarice Luz

44. Thymic Involution and Thymic Renewal
Frances T. Hakim

45. Inflamm-Aging
L. Bucci, R. Ostan, M. Capri, S. Salvioli, E. Cevenini, L. Celani, D. Monti, C. Franceschi

46. Molecular and Cellular Aspects of Macrophage Aging
Carlos Sebastián, Jorge Lloberas, Antonio Celada

Part IV. Clinical Relevance in Disease States-Infection

47. Aging and HIV Disease: Synergistic Immunological Effects?
Rita B. Effros

48. Role of Immunosenescence in Infections and Sepsis in the Elderly
Tamas Fulop, Steven Castle, Anis Larbi, Carl Fortin, Olivier Lesur, Graham Pawelec

49. Beneficial and Detrimental Manifestations of Age on CD8+ T-Cell Memory to Respiratory Pathogens
Jacob E. Kohlmeier, Kenneth H. Ely, Alan D. Roberts, Eric J. Yager, Marcia A. Blackman, David L. Woodland

50. HIV Infection as a Model of Accelerated Immunosenescence
Victor Appay, Delphine Sauce

51. Autoimmunity and Autoimmune Diseases in the Elderly
Ewa Bryl, Jacek M. Witkowski

52. Autoimmunity—Aging Mouse Model for Autoimmune Diseases
Yoshio Hayashi, Naozumi Ishimaru

53. Atherosclerosis—An Age-dependent Autoimmune Disease
B. Henderson, A. Rossmann, Ch. Mayerl, M. Wick, G. Wick

54. Immuno-Inflammatory Athero-Arteriosclerosis Induced by Elastin Peptides. Effect of Age
L. Robert, A. M. Robert

55. Aging, Immunity and Cancer
Claude Sportès, Frances T. Hakim

56. Breast Cancer and Immunosenescence
Mauro Provinciali, Alessia Donnini, Arianna Smorlesi, Cristina Gatti

57. Aging, Cancer and Apoptosis in Animal Models and Clinical Settings
Masanobu Kitagawa, Katsuiku Hirokawa

58. Her-2/neu Transgenic Mice for Evaluation of Immune and Antitumor Responses Against Self-Tumor Antigens in the Young and the Old
Joseph Lustgarten, Noweeda Mirza

59. Cancer Immunotherapy and Aging: Lessons From the Mouse
Claudia Gravekamp

60. Insulin Resistance, Chronic Inflammation and the Link with Immunosenescence
Dawn J. Mazzatti, Kavita Karnik, Radu C. Oita, Jonathan R. Powell

61. Decline of Immune Responsiveness: A Pathogenetic Factor in Alzheimer’s Disease?
Elke Richartz-Salzburger, Niklas Koehler

62. Inflammatory Markers and Frailty
Sean X. Leng, Linda P. Fried

63. CMV Infection and Frailty: Immunologic Consequences and Disease Pathogenesis
George C. Wang, Jeremy Walston

64. Osteoporosis, Inflammation and Ageing
Lia Ginaldi, Lucia P. Mengoli, Massimo Martinis

Part V. Modulation- Nutrition

65. Protein-Energy Malnutrition as a Determinant for Immuno-Senescence
Anis Larbi, Bruno Lesourd, Tamas Fulop

66. Role of Zinc and Selenium in Oxidative Stress and Immunosenescence: Implications for Healthy Ageing and Longevity
Eugenio Mocchegiani, Marco Malavolta

67. Immunomoduation by Polyunsaturated Fatty Acids: Impact on T-cell Functions and Signaling
Maximilian Zeyda, Thomas M. Stulnig

68. Omega-3 Polyunsaturated Fatty Acids and Immunosenescence
Christopher A. Jolly, Sirisha Karri

69. Effect of Intrinsic and Extrinsic Lipids on T-cell Signalling
Anis Larbi, Emilie Combet, Graham Pawelec, Tamas Fulop

70. Effect of Anti-influenza Vaccination on Immune System in the Elderly
Piotr Trzonkowski

71. Immunosenescence Modulation by Vaccination
Janet E. McElhaney

72. Interleukin -7 and Immunorejuvenation
Wayne A. Mitchell, Richard Aspinall

73. Assessment of Age-related Decline of Immunological Function and Possible Methods for Immunological Restoration in Elderly
Katsuiku Hirokawa, Masanori Utsuyama, Yuko Kikuchi, Masanobu Kitagawa

74. Thymic Regeneration in Mice and Humans Following Sex Steroid Ablation
Anne Fletcher, Jessica Reiseger, Katerina Vlahos, Natalie Seach, Jarrod Dudakov, Ann Chidgey, Richard Boyd

75. Nutraceuticals and Immune Restoration in the Elderly
Barry W. Ritz, Elizabeth M. Gardner

76. Gene Therapy and Immune Senescence
Jian Chen, Hui-Chen Hsu, John D. Mountz

77. Perspectives: Is Immunosenescence Clinically Relevant?
Tamas Fulop, Claudio Franceschi, Katsuiku Hirokawa, Graham Pawelec

Keywords: Biomedicine, Biomedicine general, Immunology, Geriatrics/Gerontology

Publication year
Page amount
1683 pages
Medicine, Health Care, Mode

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