Creatine and Creatine Kinase in Health and Disease

1. Introduction – Creatine: Cheap Ergogenic Supplement with Great Potential for Health and Disease
Theo Wallimann

2. Early Evolution of the Creatine Kinase Gene Family and the Capacity for
Creatine Biosynthesis and Membrane Transport
W. Ross Ellington, Tomohiko Suzuki

3. The Creatine Kinase Phosphotransfer Network: Thermodynamic and
Kinetic Considerations, the Impact of the Mitochondrial Outer
Membrane and Modelling Approaches
Valdur Saks, Tuuli Kaambre, Rita Guzun, Tiia Anmann, Peeter Sikk, Uwe Schlattner, Theo Wallimann, Mayis Aliev, Marko Vendelin

4. Expression and Function of Agat, Gamt and CT1 in the Mammalian Brain
Olivier Braissant, Claude Bachmann, Hugues Henry

5. A Novel Relationship Between Creatine Transport at the Blood-Brain and Blood-Retinal Barriers, Creatine Biosynthesis, And its Use for Brain and Retinal Energy Homeostasis
Masanori Tachikawa, Ken-Ichi Hosoya, Sumio Ohtsuki, Tetsuya Terasaki

6. Functional Insights into the Creatine Transporter
David L. Christie

7.
In Vivo Magnetic Resonance Spectroscopy of Transgenic Mice with Altered Expression of Guanidinoacetate Methyltransferase and Creatine Kinase Isoenzymes
Arend Heerschap, Hermien E. Kan, Christine I.H.C. Nabuurs, W. Klaasjan Renema, Dirk Isbrandt, BÉ Wieringa

8. Cerebral Creatine Deficiency Syndromes: Clinical Aspects, Treatment and Pathophysiology
Sylvia Stockler, Peter W. Schutz, Gajja S. Salomons

9. Pre-Symptomatic Treatment of Creatine Biosynthesis Defects
Andreas Schulze, Roberta Battini

10. Clinical Use of Creatine in Neuromuscular and Neurometabolic Disorders
Mark A. Tarnopolsky

11. The Neuroprotective Role of Creatine
Autumn M. Klein, Robert J. Ferrante

12. Ergogenic Effects of Creatine in Sports and Rehabilitation
Peter Hespel, Wim Derave

13. Pharmacokinetics of Creatine
Wesley Mccall, Adam M. Persky

14. Safety of Creatine Supplementation
Adam M. Persky, Eric S. Rawson

15. Creatine – its Chemical Synthesis, Chemistry, and Legal Status
Ivo Pischel, Thomas Gastner

16. Creatine and Creatine Kinase in Health and Disease – A Bright Future Ahead?
Markus Wyss, Olivier Braissant, Ivo Pischel, Gajja S. Salomons, Andreas Schulze, Sylvia Stockler, Theo Wallimann

Keywords: Medicine & Public Health, Neurology, Medical Biochemistry, Human Genetics, Quality of Life Research