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Smith, Rodney

Cell Technology for Cell Products

Smith, Rodney - Cell Technology for Cell Products, ebook

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ISBN: 9781402054761
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Table of contents

CHAPTER I. : PERSPECTIVES OF THE BIOTECH INDUSTRY

1. The UK bioprocessing sector
Tony Bradshaw

CHAPTER II. : TRANSCRIPTION TO SECRETION

2. A Novel AIR-induced Gene Expression System in HEK.EBNA Cells and its Applications
Nicola Susann Werner, Sabine Geisse, Wilfried Weber, Martin Fussenegger

3. Towards Stronger Gene Expression - a Promoter's Tale
Stephan Kalwy, James Rance, Alison Norman, Robert Gay

4. Improving the Expression of a Soluble Receptor:Fc fusion Protein in CHO Cells by Coexpression with the Receptor Ligand
Gene W. Lee, Jill K. Fecko, Ann Yen, Deb Donaldson, Clive Wood, Scott Tobler, Suresh Vunuum, Yin Luo, Mark Leonard

5. Growth, Apoptosis and Functional Genomics Analysis of CHO-K1 Over-Expressing Telomerase
Francesco Crea, Donatella Sarti, Francesco Falciani, Mohamed Al-Rubeai

6. Microarray Analysis of Metabolically Engineered NS0 Cell Lines Producing Chimeric Antibody
G. Khoo, F. Falciani, M. Al-Rubeai

7. Optimizing Medium for Transient Transfection
Z.-H. Geng, W. Nudson, L. Davis, S. Luo, K. Etchberger

8. Establishment of Recombinant CHO Cell Lines Under Serum-free Conditions
Maya Kuchenbecker, Bernd Rehberger, Michael Schriek, Judith Gackowski, Ralf Fehrenbach

9. Novel Cell-based Assay for the Detection of Murine type I IfN
Mariela Bollati-Fogolín, Werner Müller

10. Characterisation of the Induction of Cytochrome p450 Enzymes in Primary Cultures of Human Hepatocytes
T.L. Freeman, A.P. Chadwick, M.S. Lennard, C.M. Martin, R.G. Turcan, D. Blond

11. Effect of Culture Conditions on Glycosylation of Recombinant beta-Interferon in CHO Cells
Maureen Spearman, Jose Rodriguez, Norm Huzel, Kevin Sunley, Michael Butler

12. Induction of Caspase-3-dependent Apoptosis by Electrolyzed Reduced Water/platinum Nanoparticles in Cancer Cells
T. Hamasaki, S. Aramaki, T. Imada, K. Teruya, S. Kabayama, Y. Katakura, K. Otubo, S. Morisawa, S. Shirahata

13. Molecular Mechanism of TAK1-Induced Repression of hTERT Transcription
M. Maura, Y. Katakura, T. Miura, T. Fujiki, H. Shiraishi, S. Shirahata

14. Analysis of Genetic Parameters in Order to Get More Information on High Producing Recombinant CHO Cell Lines
Christine Lattenmayer, M. Loeschel, K. Schriebl, E. Trummer, K. Vorauer-Uhl, D. Mueller, H. Katinger, R. Kunert

15. Redox Regulation by Reduced Waters as Active Hydrogen Donors and Intracellular ROS Scavengers for Prevention of type 2 Diabetes
S. Shirahata, Y. Li, T. Hamasaki, Z. Gadek, K. Teruya, S. Kabayama, K. Otsubo, S. Morisawa, Y. Ishii, Y. Katakura

16. Transcription Profiling of Different Recombinant CHO Clones Based on Cross-species Microarray Analysis
Evelyn Trummer, Wolfgang Ernst, Dethardt Müller, Kornelia Schriebl, Christine Lattenmayer, Karola Vorauer-Uhl, Renate Kunert, Hermann Katinger, Friedemann Hesse

17. Adaptation without Cell Division?
K.L. Astley, M. Al-Rubeai

18. Release of Plasmid-DNC from PEI/DNA Particles
Martin Bertschinger, Arnaud Schertenleib, Gaurav Backliwal, Martin Jordan, Florian M. Wurm

19. Efficient Cloning Method for Variable Region Genes of Antigen Specific Human Monoclonal Antibody
Shinei Matsumoto, Yoshinori Katakura, Makiko Yamashita, Yoshihiro Aiba, Kiichiro Teruya, Sanetaka Shirahata

20. Design Approach Regarding Humanization and Functionality of an Anti-CD18 Monoclonal Antibody
Cristina A. Caldas, Diorge P. Souza, Maria Teresa A. Rodrigues, Andréa Q. Maranhão, Ana M. Moro, Marcelo M. Brigido

21. Development of a Transient Mammalian Expression Process for the Production of the Cancer Testis Antigen NY-ESO-1
David L. Hacker, Leonard Cohen, Natalie Muller, Huy-Phan Thanh, Elisabeth Derow, Gerd Ritter, Florian M. Wurm

22. The Role of the Sumoylation Pathway in Transient and Stable Recombinant Protein Expression in Chinese Hamster Ovary Cells
Martin Bertschinger, David Hacker, Florian Wurm

23. Effect of Different Materials Used in Bioreactor Equipments on Cell Growth of Human Embryonic Kidney (HEK293) Cells Cultivated in a Protein-free Medium
Peter Aizawa, Göran Karlsson, Charlotte Benemar, Vera Segl, Kristina Martinelle, Elisabeth Lindner

24. Antibody Production by GS-CHO Cell Lines Over Extended Culture Periods
A.J. Porter, A.J. Dickson, L.M. Barnes, A.J. Racher

25. Growth Promoting Effect of a Hydrophilic Fraction of the Protein Hydrolysate Primatone on Hybridoma Cells
Michael Schomberg, Christian Hakemeyer, Heino Büntemeyer, Lars Stiens, Jürgen Lehmann

26. Effect of the Scaffold in Maintenance of Suitable Chondrcyte Morphology in Cartilage Regeneration
J. Rodríguez, X. Rubiralta, J. Farré, P.J. Fabregues, J.M. Aguilera, J. Barrachina, F. Granell, J. Nebot, J.J. Cairó, F. Gòdia

27. Metabolic Changes Occuring During Adaptation to Serum Free Media
Sam Denby, Frank Baganz, David Mousdale

28. The Expression of the neo gene in GS-NS0 Cells Increases their Proliferative Capacity
Farlan Veraitch, Mohamed Al-Rubeai

CHAPTER III. : THERAPEUTIC CELL ENGINEERING

29. The Therapeutic Potential of Human Embryonic Stem Cells
S.H. Cedar, M.J. Patel, S.J. Pickering, P.R. Braude, S.L. Minger

30. Investigations of Murine Embryonic Stem Cell Maintenance by Analyses of Culture Variables and Gene Expression
James M. Piret, Clive H. Glover, Michael Marin, Mohammed A. S. Chaudhry, Connie J. Eaves, Bruce D. Bowen, R. Keith Humphries, Cheryl D. Helgason, Jennifer Bryan

31. Generation of Cardiomyocytes Derived from Mouse ESC in a Scale-up System
S. Niebruegge, H. Ebelt, M. Jungblut, H. Baer, M. Schroeder, R. Zweigerdt, T. Braun, J. Lehmann

32. Expansion of Undifferentiated Human Embryonic Stem Cells
Andre B.H. Choo, Jeremy Crook, Steve K.W. Oh

33. New Electrofusion Devices for the Improved Generation of Dendritic Cell-tumour Cell Hybrids
Janina Schaper, Hermann Richard Bohnenkamp, Thomas Noll

34. Influence of c-Myc and bcl-2 CO-expression on Proliferation, Apoptosis and Survival in CHO Cultures
Vasiliki Ifandi, Mohamed Al-Rubeai

35. Ex Vivo Expansion of Hematopoietic Stem Cells Using Defined Culture Media
J. Hartshorn, A.S.-H. Chan, Z.-H. Geng, L. Davis, S. Luo, J. Ni, K. Etchberger

36. Development of A Novel Serum-free Cryopreservative Solution
T. Toyosawa, M. Sasaki, Y. Kato, H. Yamada, S. Terada

37. Hepatic Cell Lines CultureD on Different Scaffolds and in Different Stages for Bioartificial Liver Systems
Kozue Kaito, Yumi Narita, Satoshi Terada

38. Comparison of Flask and Bag Systems in Cultivation of Dendritic Cells for Clinical Application
L. Macke, B. Wrobel, W. Meyring, H.S.P. Garritsen, B. Wörmann, M. Rhode, W. Lindenmaier, K.E.J. Dittmar

39. T-Lymphocytes Transduced with SFCMM-3 Vector in a Closed System
Claudia Benati, Roberto Sciarretta Birolo, Simona La Seta Catamancio, Marina Radrizzani, Cecilia Sendresen, Salvatore Toma

40. Influence of Down-regulation of Caspase-3 and CASPASE-7 by Sirnas on Sodium Butyrate-induced Apoptotic Cell Death of Chinese Hamster Ovary Cells Producing Thrombopoietin
Yun Hee Sung, Soon Hye Park, Sung Hyun Kim, Gyun Min Lee

CHAPTER IV. : GENE MEDICINE

41. UTRtech™: Exploiting mRNA Targeting To Increase Protein Secretion From Mammalian Cells
Beate Stern, Christine Gjerdrum, Stian Knappskog, Laura Minsaas, Stian Nylund, Lene C. Olsen, Litta Olsen, Eystein Oveland, Hanne Ravneberg, Christiane Trösse, Anja Tveit, Endre Vollsund, John E. Hesketh, Albert Tauler, Ian F. Pryme

42. Semi-Synthetic Mammalian Gene Regulatory Networks
B.P. Kramer, M. Fischer, M. Fussenegger

43. Acoustic Cell Processing for Viral Transduction or Bioreactor Cell Retention
V.M. Gorenflo, P. Beauchesne, V. Tayi, O. Lara, H. Drouin, J.B. Ritter, V. Chow, C. Sherwood, B.D. Bowen, J.M. Piret

44. Comparison of Different Transient Retroviral Transfection Systems
V. Kleff, I. Rattmann, C. Ludwig, M. Flasshove, T. Moritz, B. Opalka

CHAPTER V. : CELLS TO TISSUES

45. Artificial Human Lymphnode
C. Giese, U. Marx

46. Single Cell Study in a Hydrogel
T. Braschler, R. Johann, U. Seger, H. Van Lintel, P. Renaud

47. Predicting Tissue Assembly of Prostate Cancer Spheroids
Kim O’Connor, Cristina Vidulescu, Sanda Clejan, Hong Song, Mark Venczel

48. Cultivating Cells of Different Origin for 3d Bone Constructs Considering Physiological Conditions
K. Suck, C. Kasper, C. Hildebrandt, S. Diederichs, M. Fischer, T. Scheper, M. van Griensven

49. Guidance on Good Cell Culture Practice
Sandra Coecke, Michael Balls, Gerard Bowe, John Davis, Gerhard Gstraunthaler, Thomas Hartung, Robert Hay, Anna Price, Otto-Wilhelm Merten, William Stokes, Leonard Schechtman, Glyn Stacey

50. In Vitro Vascularization of Human Microtissues
J. M. Kelm, C. Diaz Sanchez-Bustamante, M. Fussenegger

51. Preparation of Salmon Atelocollagen Fibrillar Gel and Its Application to the Cell Culture
Nobuhiro Nagai, Shunji Yunoki, Takeshi Suzuki, Yasuharu Satoh, Kenji Tajima, Masanobu Munekata

52. Propagation of USSC for Therapeutic Approaches
J. Lamlé, H. Büntemeyer, A. Reinel, T. Menne, C. van den Bos, J. Lehmann

53. Bioreactor Based Production of Functional Conditioned Medium for the Propagation of Undifferentiated Human Embryonic Stem Cells
A. Bauwens, H. Büntemeyer, S. Terstegge, T. Nottorf, O. Brüstle, J. Lehmann

54. Large-scale Expansion of Cells for Use as Therapeutic Agents
Juan Melero-Martin, Shanmugapriya Santhalingam, Mohamed Al-Rubeai

55. EX VIVO Expansion of CD34+ Cells in Stemline II Hematopoietic Stem Cell Expansion Medium Generates a Large Population of Functional Early and Late Progenitor Cells
Stacy L. Leugers, Daniel W. Allison, Ying Liang, Carol Swiderski, Gary Van Zant, Laurel M. Donahue

56. In Vitro Bone Formation of Multipotential Human Mesenchymal Cells in Fixed Bed Perfusion Bioreactors
Nadia Zghoul, Martijn van Griensven, Johannes Zeichen, Kurt E.J. Dittmar, Manfred Rohde, Volker Jäger

57. Influence of Basal Media Formulations and Calcium on Growth and Directed Differentiation of Human Osteogenic Cells In Vitro

Ingrida Majore, M. Morris Hosseini, Hubert Mayer, Volker Jäger

CHAPTER VI. : PROTEIN PRODUCTS

58. BHRF-1 as a Tool for Genetic Inhibition of Apoptotis in Hybridoma Cell Cultures
S. Juanola, J. Vives, J. Gálvez, P. Ferrer, R. Tello, J.J. Cairó, F. Gòdia

59. Karyotype of CHO DG44 cells
D. Martinet, M. Derouazi, N. Besuchet, M. Wicht, J. Beckmann, F.M. Wurm

60. From Biopsy to Cartilage-carrier-constructs by Using Microcarrier Cultures as Sub-process
Stephanie Nagel-Heyer, Svenja Lünse, Christian Leist, Roman Böer, Christiane Goepfert, Ralf Pörtne

61. Effect of Peptones and Study of Feeding Strategies in a CHO Based Fed-batch Process for the Production of a Human Monoclonal Antibody
Véronique Chotteau, Caroline Wåhlgren, Helena Pettersson

62. Retinoic Acid Induced Up-regulation of Monoclonal Antibody Production
Yuichi Inoue, Hiroharu Kawahara, Sanetaka Shirahata, Yasushi Sugimoto

63. Media and Cell Manipulation Approaches to the Reduction of Adaptation Time in GS NS0 Cell Line
Paul Clee, Mohamed Al-Rubeai

64. The Production of Human Growth Hormone
Fabienne Anton, Alexander Tappe, Cornelia Kasper, Alexander Loa, Bernd-Ulrich Wilhelm, Thomas Scheper

65. Preparation of Membrane Receptor Proteins Utilising Large Scale Micro-carrier Culture and a "Pearl Freezing Factory" to Finalise the Product
Irma Jansson, Thomas Fröberg, Anette Danielsson, Elke Lullau

66. Silk Protein Sericin Improves Mammalian Cell Culture
Satoshi Terada, Naoki Takada, Kazuaki Itoh, Takuya Saitoh, Masahiro Sasaki, Hideyuki Yamada

67. Design of Culture Media for Drosophila Melanogaster S2 Cells Producing Recombinant G Glycoprotein from Rabies Virus
A.L.L. Galesi, F.R.X. Batist, R.Z. Mendonça, C.A. Pereira, A.M. Moraes

68. Comparison of the Cultivation of Wild and Transfected Drosophila Melanogaster S2 Cells in Different Media
K. Swiech, A.L.L. Galesi, A.M. Moraes, R.Z. Mendonça, C.A. Pereira, C.A.T. Suazo

69. Low Temperature Culture Effects on sCR1 Productivity by rCHO Cells
Hiroshi Matsuoka, Chie Shimizu, Toshiya Takeda

70. Proteomic Characterization of Recombinant NS0 Cell Clones Obtained by an Integrated Selection Strategy
Adolfo Castillo, Kathya R. De La Luz, Svieta Victores, Luis Rojas, Yamilet Rabasa, Simon Gaskell, Rolando Perez

71. IFN-γ Glycosylation Macroheterogeneity and Intracellular Nucleotide and Sugar Nucleotide Contents of CHO Cells Cultivated in Batch Culture
N. Kochanowski, F. Blanchard, E. Guedon, A. Marc, R. Cacan, F. Chirat, J.-L. Goergen

72. Influence of the Adaptation Procedure and the Serum-free Conditions on the N-glycosylation Pattern of EPO Produced by CHO Cells
F. Le Floch, B. Tessier, J.-M. Guillaume, P. Cans, A. Marc, J.-L. Goergen

73. Stability and Cytogenetic Characterization of Recombinant CHO Cell Lines Established by Microinjection and Calcium Phosphate Transfection
M. Derouazi, D. Martinet, N. Besuchet, R. Flaction, M. Wicht, M. Bertschinger, D. Hacker, J. Beckmann, F.M. Wurm

74. Efficient Cloning Method for Variable Region Genes of Antigen Specific Human Monoclonal Antibody
Shinei Matsumoto, Yoshinori Katakura, Makiko Yamashita, Yoshihiro Aiba, Kiichiro Teruya, Sanetaka Shirahata

75. Design Approach Regarding Humanization and Functionality of an Anti-CD18 Monoclonal Antibody
Cristina A. Caldas, Diorge P. Souza, Maria Teresa A. Rodrigues, Andréa Q. Maranhão, Ana M. Moro, Marcelo M. Brigido

76. Development of a Transient Mammalian Expression Process for the Production of the Cancer Testis Antigen NY-ESO-1
David L. Hacker, Leonard Cohen, Natalie Muller, Huy-Phan Thanh, Elisabeth Derow, Gerd Ritter, Florian M. Wurm

77. Effect of Different Materials used in Bioreactor Equipments on Cell Growth of Human Embryonic Kidney (HEK293) Cells Cultivated in a Protein-free Medium
Peter Aizawa, Göran Karlsson, Charlotte Benemar, Vera Segl, Kristina Martinelle, Elisabeth Lindner

78. Antibody Production by GS-CHO Cell Lines Over Extended Culture Periods
A.J. Porter, A.J. Dickson, L.M. Barnes, A.J. Racher

79. Growth Promoting Effect of a Hydrophilic Fraction of the Protein Hydrolysate Primatone on Hybridoma Cells
Michael Schomberg, Christian Hakemeyer, Heino Büntemeyer, Lars Stiens, Jürgen Lehmann

80. Growth Promoting Effect of a Hydrophilic Fraction of the Protein Hydrolysate Primatone on Hybridoma Cells
Michael Schomberg, Christian Hakemeyer, Heino Büntemeyer, Lars Stiens, Jürgen Lehmann

81. Metabolic Changes Occuring During Adaptation to Serum Free Media
Sam Denby, Frank Baganz, David Mousdale

82. The Expression of the neo Gene in GS-NS0 Cells Increases Their Proliferative Capacity
Farlan Veraitch, Mohamed Al-Rubea

83. 1000 Non-instrumented Bioreactors in a Week
Matthieu Stettler, Maria De Jesus, Hajer Ouertatani-Sakouhi, Eva Maria Engelhardt, Natalie Muller, Sébastien Chenuet, Martin Bertschinger, Lucia Baldi, David Hacker, Martin Jordan, Florian M. Wurm

84. Optimisation of Time-space-yield for Hybridoma fed-batch Cultures with an Adaptive Olfo-controller
Ralf Pörtner, Björn Frahm, Paul Lane, Axel Munack, Kathrin Kühn, Volker C. Hass

85. Influenza Vaccines – Challenges in Mammalian Cell Culture Technology
Yvonne Genzel, Josef Schulze-Horsel, Lars Möhler, Yury Sidorenko, Udo Reichl

86. Towards pCO2-optimised Fermentations – Reliable Sampling, pCO2 Control & Cellular Metabolism
Alexander Jockwer, Christian Klinger, Jochem Gätgens, Detlef Eisenkrätzer, Thomas Noll Gätgens

87. Cultivation of E-FL in Perfusion Mode using Wave® Bioreactor and Stirred-Tank Reactor for Parvovirus Vaccine Production
B. Hundt, S. Straube, N. Schlawin, H. Kaßner, U. Reichl

88. Repeated Batch Fermentation Using a Viafuge Centrifuge
Kurt Russ, Peter Schlenke, Harald Huchler, Hans Hofer, Maya Kuchenbecker, Ralf Fehrenbach

89. Serum-free Transient Expression of Antibodies Using 40 Tray Cell Factories
Peter Schlenke, Katrin Langnickel, Thilo Grob, Frank Kohne, Hans Hofer, Ulrike Brändle, Kurt Russ, Ralf Fehrenbach

90. Monitoring Cell Physiology in Influenza Vaccine Production by Flow Cytometry
Josef Schulze-Horsel, Yvonne Genzel, Udo Reichl

91. NucleoCounter – An Efficient Technique for the Determination of Cell Number and Viability in Animal Cell Culture Processes
Dimpalkumar Shah, Paul Clee, Sthen Boisen, Mohammed Al-Rubeai

92. On-line Biomass Monitoring in Cell Culture with Scanning Radio-frequency Impedance Spectroscopy
J.P. Carvell, C. Cannizzaro

93. The Use of a Mobile Robot for Complete Sample Management in a Cell Culture Pilot Plant
Martin Wojtczyk, Rüdiger Heidemann, Klaus Joeris, Chun Zhang, Mark Burnett, Alois Knoll, Konstantin Konstantinov

94. Closed Loop Control of Perfusion Systems in High-density Cell Culture
A. Bock, U. Reichl

95. Optimization of Culture Medium with the Use of Protein Hydrolysates
Paul Ganglberger, Bernd Obermüller, Manuela Kainer, Peter Hinterleitner, Otto Doblhoff, Karlheinz Landauer

96. Optimization of a Fed-batch Strategy for Production of Mab Ign 311 in Small Scale Experiments
P. Hinterleitner, P. Ganglberger, B. Obermüller, B. Antes, O. Doblhoff, K. Landauer

97. Serum-free Influenza Vaccine Production with MDCK Cells in Wave-bioreactor and 5L-stirred Tank Bioreactor
Yvonne Genzel, Marlies Fischer, Ruth Maria Olmer, Bastian Schäfer, Claudia Best, Susanne König, Boris Hundt, Udo Reichl

98. Rotary Bioreactor for Recombinant Protein Production
Stephen Navran

99. Flow Cytometry as a Tool for Process Monitoring of Virus-cell Systems
K.S. Sandhu, M. Al-Rubeai

100. The Use of Multi-parameter Flow Cytometry for Characterisation of Insect Cell-baculovirus Cultures
B. Isailovic, R. Hicks, I.W. Taylor, A. Nienow, C.J. Hewitt

101. Understanding Metabolic Needs of EB14 Cells in Culture
J. Hartshorn, F. Guehenneux, K. Kolell, Z.-H. Geng, E. Atarod, T. Mohabbat, C. McCormick, P. Sutrave, C. Hernandez, M. Avery, S. Luo, M. Mehtali, K. Etchberger

102. Virus Production in Vero Cells Using a Serum-free Medium
K. Kolell, J. Padilla-Zamudio, B. Schuchhardt, S. Gilliland, S. McNorton, B. Dalton, S. Luo, K. Etchberger

103. Computational Fluid Dynamics Applied to Laboratory Scale Cell Culture Reactors for the Prediction of Hydrodynamic Stress
Eric Olmos, Nicolas Fischbach, Annie Marc

104. Using Genomic Tools for the Identification of Important Signaling Pathways in Order to Facilitate Cell Culture Medium Development
Daniel W. Allison, Kathryn A. Aboytes, Terrell K. Johnson, Danny K. Fong, Stacy L. Leugers, Melissa L. Hoepner, Laurel M. Donahue

105. Development and Application of an Animalcomponent Free Single-cell Cloning Medium for Chinese Hamster Ovary Cell Lines
N. Lin, J. L. Beckmann, J. Cresswell, J. S. Ross, B. Delong, Z. Deeds, M. V. Caple

106. Plant Peptones: Nutritional Properties Sustaining Recombinant Protein Secretion by CHO Cells
Johann Mols, Nicolas Cavez, Spiros Agathos, Yves-Jacques Schneider

107. Monitoring of Extracellular TCA Cycle Intermediates in Mammalian Cell Culture
Joachim B. Ritter, Yvonne Genzel, Udo Reichl

108. A Comparison of the SixFors Fermenter System and Lab Scale Fermenters For Clone Selection
Giles Wilson, Annette Jørgensen

109. Comparison of Cultivations of CHO Cell Line in Chemostat and Acceleratostat Experiments
Rasmus Bjerre Nielsen, Giles Wilson

110. Evaluation of a Novel Micro-bioreactor System for Cell Culture Optimisation
Giles Wilson

111. Comparison of Different Design Configurations of a 1-L Multi-bioreactor Station for Cell Culture Process Development
Heiko Schütte, Ulrike Kolrep, Liane Franck, Roland Wagner

112. The Effect of Genetically Modified Insulin Growth Factor on Cell Proliferation and Adenovirus Productivity in Serum Free Medium
Angela Buckler, Mohamed Al-Rubeai

113. Evaluation of a Scalable Disposable Bioreactor System for Manufacturing of Mammalian Cell Based Biopharmaceuticals
Silke Langhammer, Marco Riedel, Hikmat Bushnaq-Josting, René Brecht, Ralf Pörtner, Uwe Marx

114. Purification of Rabies Virus Produced on Vero Cells Using Chromatography Techniques
Mohamed Chtioui, Khaled Trabelsi, Héla Kallel

115. Human Growth Hormone (HGH) Purification From CHO-Cell Culture Supernatant Utilizing Macroporous Chromatographic Media
Johanna-Gabriela Walter, Alexander Tappe, Cornelia Kasper, Robert Zeidler, Oscar-Werner Reif, Thomas Scheper

116. Process Development for a Veterinary Vaccine Against Heartwater Using Stirred Tanks
Isabel Marcelino, Marcos F.Q. Sousa, Ana Amaral, Cristina Peixoto, Célia Verissimo, Antonio Cunha, Manuel J.T. Carrondo, Paula M. Alves

117. Working Towards a Chemically-defined Replacement for Hydrolysates
Zachary W. Deeds, C. Steven Updike, Benjamin J. Cutak, Matthew V. Caple

118. Effect of Vitamins or Lipids Addition on Adenovirus Production at High Cell Densities
Tiago B. Ferreira, Manuel J. T. Carrondo, Paula M. Alves

119. Observation and Analysis of Lab Scaled Microcarrier Cultivation by In-situ Microscopy with Image Processing Tools
G. Rudolph, A. Gierse, P. Lindner, C. Kasper, B. Hitzmann, T. Scheper

120. Rapeseed Peptidic Fractions as Medium Additives in Animal Cell Bioreactors
B. Farges, B. Tessier, I. Chevalot, C. Harscoat, S. Chenu, I. Marc, J.L. Goergen, A. Marc

121. Influence of Rapeseed Protein Hydrolysis Conditions on Animal Cell Growth in Serum-free Media Supplemented with Hydrolysates
G. Chabanon, I. Chevalot, B. Farges, C. Harscoat, S. Chenu, J.-L. Goergen, A. Marc, I. Marc

122. Rapid Media and Process Optimization Using DOE: A Case Study
Stacy Holdread, Ji Hee Kim, Toyin Oshunwusi, Jagdish Kuchibhatla, Cindy Hunt, James W. Brooks

123. Developing Chemically Defined Media Through DOE: Complete Optimization with Increased Protein Production in Less than 8 Months
Kimesha Hammett, Jagdish Kuchibhatla, Cindy Hunt, Stacy Holdread, James W. Brooks

124. Bioreactor Process Strategies for rNS0 Cells
Delia Fernandez, Jennifer Walowitz, William Paul, Lia Tescione, Stephen Gorfien

125. The Efficient Induction of Human Antibody Production in in Vitro Immunization by CPG Oilgodeoxynucleotides
Yoshihiro Aiba, Makiko Yamashita, Yoshinori Katakura, Sin-ei Matsumoto, Kiichiro Teruya, Sanetaka Shirahata

126. Rapid Culture Media Optimization to Gain Multiple Fold Increase in Recombinant Protein Production in Two CHO Cell Lines
Scott D Storms, Aaron Chen, Jenny Yu, Tom Fletcher

127. Strategies for Large Scale Production of Parapoxvirus Ovis NZ-2
M. Pohlscheidt, U. Langer, B. Bödeker, D. Paulsen, H. Rübsamen-Waigmann, U. Reichl, H.J. Henzler, H. Apeler

128. Proteomic Investigation of Recombinant CHO Cells in High Density Culture
J.R. Cresswell, J.M. Zobrist, J. Wildsmith, N. Lin, R. Valdes-Camin, M. Caple

129. Comparative Proteomic Study of Mechanisms Involved in the Expression of Recombinant Monoclonal Antibody in Non Amplified NS0 Myeloma Cell Line
Luis E. Rojas, Kathya R. de la Luz Hernández, Svieta Victores, Lila Castellanos, Simon Gaskell, Adolfo Castillo, Rolando Pérez

130. Monitoring Nutrient Limitations by Online Capacitance Measurements in Batch & Fed-batch CHO Fermentations
Sven Ansorge, Geoffrey Esteban, Charles Ghommidh, Georg Schmid

131. Characterisation of Shake Flasks for Cultivation of Animal Cell Cultures
G. Jänicke, C. Sauter, R. Bux, J. Haas

132. Manufacturing of Lots of Human T-Lymphocytes for Cell Therapy
Nadia De Bernardi, Silvia Trasciatti, Antonio Orlandi, Fausto Gaspari, Ilaria Giuntini, Tiziana Bacchi, Sonia Castiglioni, Elena Muru, Marta Galagano, Claudia De Mattei, Luigi Cavenaghi, Maria Luisa Nolli

133. Oxygen Control in Static Cell Cultures
Nadia De Bernardi, Edwin Schwander, Antonio Orlandi, Ilaria Tano, Sonia Castiglioni, Elena Muru, Fausto Gaspari, Marta Galgano, Claudia De Mattei, Luigi Cavenaghi, Maria Luisa Nolli

134. The Effects of Cell Separation with Hydrocyclones on the Viability of CHO Cells
Rodrigo C. V. Pinto, Ricardo A. Medronho, Leda R. Castilho

135. Erythropoietin Purification Employing Affinity Membrane Adsorbers
Maria Candida M. Mellado, David Curbelo, Ronaldo Nobrega, Leda R. Castilho

136. Cultivation of Vero Cells on Microporous and Macroporous Microcarriers
Marta Cristina O. Souza, Marcos S. Freire, Leda R. Castilho

137. CFD-Aided Design of Hollow Fibre Modules for Integrated Mammalian Cell Retention and Product Purification
Romi L. Machado, Alvio Figueredo, Danilo G. P. Carneiro, Leda R. Castilho, Ricardo A. Medronho

138. Comparison of Manufacture Technologies for RAV12 Monoclonal Antibody in Production Medium Containing No Animal Derived Proteins
Irene Shackel, Amy Bass, Arno Brewer, Peter Brown, Mary C. Tsao, Lucille W.S. Chang

139. Highly Efficient Serum-free Production of Biopharmaceuticals in CHO-Cells
S. Zahn, K. Abst, N. Palmen, S. Schindler, A. Herrmann

140. A New Host Cell-line for the Fast, Reproducible and Efficient Production of Biopharmaceuticals
B. Greulich, H.F. Abts, S. Zahn, A. Herrmann

141. Proteomic Characterization of Recombinant NS0 Cell Clones Obtained by an Integrated Selection Strategy
Adolfo Castillo, Kathya r. De La Luz, Svieta Victores, Luis Rojas, Yamilet Rabasa, Simon Gaskell, Rolando Perez

142. Analysis and Modeling of the Metabolism of Lepidopteran Cell Lines
Jean-Christophe Drugmand, Yves-Jaques Schneider, Spiros Agathos

143. Growth of Mammalian and Lepidopteran Cells on BioNOC® II Disks, a Novel Macroporous Microcarrier
Jean-Christophe Drugmand, Jean-François Michiels J.-F., Spiros Agathos, Yves-Jaques Schneider

144. Screening Strategies for Iron Chelators in Serum Free Media
Joanne Keenan, Dermot Pearson, Martin Clynes

145. Production of Human Growth Hormone in a Mammalian Cell High Density Perfusion Process
T. Nottorf, W. Hoera, H. Buentemeyer, S. Siwiora-Brenke, A. Loa, J. Lehmann

146. Development of an Integrated Qualitative and Quantitative Approach to Study Expression- Secretion Bottlenecks of Mammalian cDNAs in HEK293 EBNA Cells
Loïc Glez, Christine A. Power, Thierry Battle, Georg Feger

147. Rotating Bed Bioreactors: a Novel Way to Natural Proteins by Tissue-like Cultivation of Mammalian Cells
Hans P.A. Hoffmeister

148. Minireactors for Animal Cell Culture: Monitoring of Cell Concentration and Cellular Activity
A. Soley, J. Gálvez, E. Sarró, M. Lecina, A. Fontova, R. Bragós, J.J. Cairó, F. Gòdia

149. Air-lift Bioreactor Improvement of Scale-up Linearity Between Shake Flasks and 25-L Scale in the Insect Cells—baculovirus Expression System
Frédéric Bollin, Christophe Losberger, Laurent Chevalet, Thierry Battle

Keywords: Chemistry, Biotechnology

Author(s)
Publisher
Springer
Publication year
2007
Language
en
Edition
1
Page amount
900 pages
Category
Natural Sciences
Format
Ebook
eISBN (PDF)
9781402054761

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