Structure-Based Drug Discovery

1. Five Years of Increasing Structural Biology Throughput - A Retrospective Analysis
Enrique Abola, Dennis D. Carlton, Peter Kuhn, Raymond C. Stevens

2. Protein Production for Structural Genomics - Strategies for the Next Phase
Pär Nordlund, Tobias Cornvik, Helena Berglund

3. Introduction to Fragment Screening
Andrew R. Leach, Michael M. Hann

4. Fragment-Based NMR Screening in Lead Discovery
Christopher A. Lepre, Jonathan M. Moore

5. Fragment-Based Screening by X-ray Crystallography
Valerio Berdini, Marc O’Reilly, Miles S. Congreve, Ian J. Tickle

6. Scaffold-Based Drug Discovery
Kam Y. J. Zhang, Michael V. Milburn, Dean R. Artis

7. Biophysical Methods
Chun-Wa Chung, Peter N. Lowe

8. Illustration of Current Challenges in Molecular Docking
Marcel L. Verdonk, Richard D. Taylor, Gianni Chessari, Christopher W. Murray

9. Scoring Functions
Luca A. Fenu, Richard A. Lewis, Andrew C. Good, Michael Bodkin, Jonathan W. Essex

DRM-restrictions

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Keywords: SCIENCE / Chemistry / General SCI013000