25 Years of p53 Research

1. The First Twenty-Five Years of p53 Research
Harlan Robins, Gabriela Alexe, Sandra Harris, A. J. Levine

2. Regulation of p53 DNA Binding
Kristine McKinney, Carol Prives

3. 20 Years of DNA Damage Signaling to p53
Kevin G. McLure, Michael B. Kastan

4. Gatekeepers of the Guardian: p53 Regulation by Post-Translational Modification, MDM2 and MDMX
Geoffrey M. Wahl, Jayne M. Stommel, Kurt Krummel, Mark Wade

5. Regulation of the p53 Response by Cellular Growth and Survival Factors
Lauren Brown, Samuel Benchimol

6. P53, Cell Cycle Arrest and Apoptosis
Shulin Wang, Wafik S. El-Deiry

7. P53 Has a Direct Pro-apoptotic Action at the Mitochondria
Ute M. Moll

8. Manipulating the p53 Gene in the Mouse: Organismal Functions of a Prototype Tumor Suppressor
Lawrence A. Donehower, Dora Bocangel, Melissa Dumble, Guillermina Lozano

9. P53, P63, and P73: Internecine Relations?
Frank McKeon, Annie Yang

10. P73, P63 and Mutant P53: Members of Protein Complexs Floating in Cancer Cells
Olimpia Monti, Alexander Damalas, Sabrina Strano, Giovanni Blandino

11. P53: Gatekeeper, Caretaker or Both?
Carlos P. Rubbi, Jo Milner

12. Analysis of p53 Gene Alterations in Cancer: A Critical View
Thierry Soussi

13. Patterns of TP53 Mutations in Human Cancer: Interplay Between Mutagenesis, DNA Repair and Selection
Hong Shi, Florence Calvez, Magali Olivier, Pierre Hainaut

14. Prognostic and Predictive Value of TP53 Mutations in Human Cancer
Magali Olivier, Pierre Hainaut, Anne-Lise Børresen-Dale

15. P53 Links Tumor Development to Cancer Therapy
Michael T. Hemann, Scott W. Lowe

16. Novel p53-Based Therapies: Strategies and Future Prospects
Sonia Lain, David Lane

17. Wild Type p53 Conformation, Structural Consequences of p53 Mutations and Mechanisms of Mutant p53 Rescue
Andreas C. Joerger, Assaf Friedler, Alan R. Fersht

18. Mutant p53 Reactivation as a Novel Strategy for Cancer Therapy
Galina Selivanova, Vladimir J. N. Bykov, Klas G. Wiman

19. Novel Approaches to p53-Based Therapy: ONYX-015
Frank McCormick

20. p53 as Seen by an Outsider
George Klein

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Keywords: TECHNOLOGY & ENGINEERING / Biomedical TEC059000