The opening chapter defines and introduces cluster randomized trials, before going on to present an overview of the subject's history and recent developments. The following chapters focus on all the major issues presented in the order in which investigators think about issues when they are designing a trial. The chapters focus on: trial quality, reporting, how to design an intervention, how to ensure the validity of results, how to choose both the design and the analysis of the trial, sample size calculations, choosing an intra-cluster correlation coefficient, the uses of piloting, how to conduct a cost-effectiveness analysis, and how these trials should be synthesized.
The book also contains numerous tables, graphs and diagrams and a substantial number of recent trials.
Keywords: Clinical Trials