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Coleman, Michael D.

Human Drug Metabolism

Coleman, Michael D. - Human Drug Metabolism, ebook

84,60€

Ebook, ePUB with Adobe DRM
ISBN: 9781119458616
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Printing204 pages with an additional page accrued every 4 hours, capped at 204 pages
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Provides a timely update to a key textbook on human drug metabolism

The third edition of this comprehensive book covers basic concepts of teaching drug metabolism, starting from extreme clinical consequences to systems and mechanisms and toxicity. It provides an invaluable introduction to the core areas of pharmacology and examines recent progress and advances in this fast moving field and its clinical impact.

Human Drug Metabolism, 3rd Edition begins by covering basic concepts such as clearance and bioavailability, and looks at the evolution of biotransformation, and how drugs fit into this carefully managed biological environment. More information on how cytochrome P450s function and how they are modulated at the sub-cellular level is offered in this new edition. The book also introduces helpful concepts for those struggling with the relationship of pharmacology to physiology, as well as the inhibition of biotransformational activity. Recent advances in knowledge of a number of other metabolizing systems are covered, including glucuronidation and sulphation, along with the main drug transporters. Also, themes from the last edition are developed in an attempt to chart the progress of personalized medicine from concepts towards practical inclusion in routine therapeutics. The last chapter focuses on our understanding of how and why drugs injure us, both in predictable and unpredictable ways. Appendix A highlights some practical approaches employed in both drug metabolism research and drug discovery, whilst Appendix B outlines the metabolism of some drugs of abuse. Appendix C advises on formal examination preparation and Appendix D lists some substrates, inducers and inhibitors of the major human cytochrome P450s.

  • Fully updated to reflect advances in the scientific field of drug metabolism and its clinical impact
  • Reflects refinements in the author's teaching method, particularly with respect to helping students understand biological systems and how they operate
  • Illustrates the growing relationship between drug metabolism and personalized medicine
  • Includes recent developments in drug discovery, genomics, and stem cell technologies

Human Drug Metabolism, 3rd Edition is an excellent book for advanced undergraduate and graduate students in molecular biology, biochemistry, pharmacology, pharmacy, and toxicology. It will also appeal to professionals interested in an introduction to this field, or who want to learn more about these bench-to-bedside topics to apply it to their practice.

Keywords:

drug metabolism; cell biology; molecular biology; toxicology; pharmacology; metabolism; drugs; human drug metabolism; drug toxicity; drug inhibitors; drug classes; biotransforming; cytochrome P450; genomics; ‘Phase II’ conjugative; pharmacogenetics

, Molecular Pharmacology, Biochemistry, Molecular Pharmacology, Biochemistry
Author(s)
Publisher
John Wiley and Sons, Inc.
Publication year
2019
Language
en
Edition
3
Page amount
680 pages
Format
Ebook
eISBN (ePUB)
9781119458616
Printed ISBN
9781119458562

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