Optimization Methods in Metabolic Networks

Provides a tutorial on the computational tools that use mathematical optimization concepts and representations for the curation, analysis and redesign of metabolic networks

• Organizes, for the first time, the fundamentals of mathematical optimization in the context of metabolic network analysis
• Reviews the fundamentals of different classes of optimization problems including LP, MILP, MLP and MINLP
• Explains the most efficient ways of formulating a biological problem using mathematical optimization
• Reviews a variety of relevant problems in metabolic network curation, analysis and redesign with an emphasis on details of optimization formulations
• Provides a detailed treatment of bilevel optimization techniques for computational strain design and other relevant problems

Keywords: Metabolic network modeling; Mathematical optimization; Flux Balance Analysis; Bilevel optimization, Molecular Bioengineering, Cell & Molecular Biology, Molecular Bioengineering, Cell & Molecular Biology