Limits of Detection in Chemical Analysis

Details methods for computing valid limits of detection.

• Clearly explains analytical detection limit theory, thereby mitigating incorrect detection limit concepts, methodologies and results
• Extensive use of computer simulations that are freely available to readers
• Curated short-list of important references for limits of detection
• Videos, screencasts, and animations are provided at an associated website, to enhance understanding
• Illustrated, with many detailed examples and cogent explanations

Keywords: Limit of detection; detection limit; hypothesis testing; false positives and false negatives; decision level; homoscedastic noise; probability density function; noncentral t distribution; noncentrality parameter; Monte Carlo simulations, General Chemistry, Applied Probability & Statistics, General & Introductory Chemistry, Applied Probability & Statistics