Antibody-Drug Conjugates: Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer

Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells.

•Discusses the basics, drug delivery strategies, pharmacology and toxicology, and regulatory approval strategies
•Covers the conduct and design of oncology clinical trials and the use of ADCs for tumor imaging
•Includes case studies of ADCs in oncology drug development
•Features contributions from highly-regarded experts on the frontlines of ADC research and development

Keywords: antibody-drug conjugate (ADC); therapeutic oncology; engineered targeted monoclonal antibodies; cancer cell targeting; cytotoxic drugs; oncology drug development; cancer drug development; chemistry manufacturing and controls; nonclinical ADC pharmacology; pharmacokinetics and toxicology; clinical outcomes; oncology clinical trials, Oncology & Radiotherapy, Biotechnology (Life Sciences), Oncology & Radiotherapy, Biotechnology (Life Sciences)