Oral Bioavailability Assessment: Basics and Strategies for Drug Discovery and Development

Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development.

• Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability
• Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development
• Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development
• Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)
• Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development

Keywords: Oral bioavailability; drug permeability; drug solubility; pharmacokinetics; physicochemical and biopharmaceutical parameters; drug metabolism; efflux transporters; uptake transporters; drug discovery and development; Extended Clearance Classification System (ECCS); first pass effect; fa; fg; fh; Biopharmaceutics Drug Disposition Classification System (BDDCS); preclinical and clinical development; in vitro and in vivo ADME assays, Analytical Chemistry, Clinical Pharmacology & Therapeutics, Analytical Chemistry, Clinical Pharmacology & Therapeutics