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El-Kattan, Ayman F.

Oral Bioavailability Assessment: Basics and Strategies for Drug Discovery and Development

El-Kattan, Ayman F. - Oral Bioavailability Assessment: Basics and Strategies for Drug Discovery and Development, ebook

208,30€

Ebook, ePUB with Adobe DRM
ISBN: 9781118916933
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Printing134 pages with an additional page accrued every 6 hours, capped at 134 pages
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Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development.

•    Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability
•    Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development
•    Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development
•    Includes chapters about pharmacokinetic  modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)
•    Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development

Keywords: Oral bioavailability, drug permeability, drug solubility, pharmacokinetics, physicochemical and biopharmaceutical parameters, drug metabolism, efflux transporters, uptake transporters, drug discovery and development, Extended Clearance Classification System (ECCS), first pass effect, fa, fg, fh, Biopharmaceutics Drug Disposition Classification System (BDDCS), preclinical and clinical development, in vitro and in vivo ADME assays, Drug Discovery & Development

Author(s)
 
Publisher
John Wiley and Sons, Inc.
Publication year
2017
Language
en
Edition
1
Series
Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods
Page amount
448 pages
Category
Medicine, Health Care, Mode
Format
Ebook
eISBN (ePUB)
9781118916933
Printed ISBN
9781118916698

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