Circulating Tumor Cells: Isolation and Analysis

Introduces the reader to Circulating Tumor Cells (CTCs), their isolation method and analysis, and commercially available platforms

• Presents the historical perspective and the overview of the field of circulating tumor cells (CTCs)
• Discusses the state-of-art methods for CTC isolation, ranging from the macro- to micro-scale, from positive concentration to negative depletion, and from biological-property-enabled to physical-property-based approaches
• Details commercially available CTC platforms
• Describes post-isolation analysis and clinical translation
• Provides a glossary of scientific terms related to CTCs

Keywords: circulating tumor cells; microfluidics; CellSearch; single cell analysis; rare cells; cancer; metastasis; cell sorting; microfilter; liquid biopsy; aptamers; EpCAM; heterogeneity; biomarkers, General & Introductory Biomedical Engineering, Cell & Molecular Biology, General & Introductory Biomedical Engineering, Cell & Molecular Biology