Renaud, Jean-Paul
Structural Biology in Drug Discovery: Methods, Techniques, and Practices
With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field.
The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that:
- Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology
- Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design
- Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures
- Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins
Keywords: structural biology, drug discovery, drug development, crystallization, X-ray diffraction, NMR, mass spectrometry, and computational chemistry, protein dynamics, structure-based chemogenomics, polypharmacology, fragment-based drug design, biophysics, biotherapeutics
- Editor
- Renaud, Jean-Paul
- Publisher
- John Wiley and Sons, Inc.
- Publication year
- 2020
- Language
- en
- Edition
- 1
- Page amount
- 688 pages
- Category
- Medicine, Health Care, Mode
- Format
- Ebook
- eISBN (PDF)
- 9781118900406