Renaud, Jean-Paul

Structural Biology in Drug Discovery: Methods, Techniques, and Practices

Renaud, Jean-Paul - Structural Biology in Drug Discovery: Methods, Techniques, and Practices, ebook


Ebook, PDF with Adobe DRM
ISBN: 9781118900406
DRM Restrictions

Printing206 pages with an additional page accrued every 4 hours, capped at 206 pages
Copy to clipboard5 excerpts

With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field.

The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that:

  • Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology
  • Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design
  • Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures
  • Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

Keywords: structural biology, drug discovery, drug development, crystallization, X-ray diffraction, NMR, mass spectrometry, and computational chemistry, protein dynamics, structure-based chemogenomics, polypharmacology, fragment-based drug design, biophysics, biotherapeutics

John Wiley and Sons, Inc.
Publication year
Page amount
688 pages
Medicine, Health Care, Mode

Similar titles