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Doglia, Silvia Maria

Protein Aggregation in Bacteria: Functional and Structural Properties of Inclusion Bodies in Bacterial Cells

Doglia, Silvia Maria - Protein Aggregation in Bacteria: Functional and Structural Properties of Inclusion Bodies in Bacterial Cells, ebook

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ISBN: 9781118855034
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This book focuses on the aggregation of recombinant proteins in bacterial cells in the form of inclusion bodies. Recent reports revolutionized the current view of inclusion bodies from that of inert deposits of inactive proteins to reservoirs of proteins that can eventually maintain biological activity and/or be rescued by cells.  Aggregation is put in the context of updated knowledge about the folding and aggregation of proteins in simple cells and new perspectives derived from the application of this knowledge are presented.

The following topics are addressed: a) molecular and cellular mechanisms of protein folding, aggregation
and disaggregation in bacteria; b) physiological importance and consequences of aggregation for the bacterial cell; c) factors inherent to the protein sequence responsible for aggregation and evolutionary mechanisms to keep proteins soluble; d) structural properties of proteins expressed as soluble aggregates and  as inclusion bodies within bacterial cells both from a methodological point of view and with regard to their similarity with amyloids; e) control of the structural and functional properties of aggregated proteins and use thereof in biotechnology and medicine.

Keywords: Protein Science

Author(s)
 
Publisher
John Wiley and Sons, Inc.
Publication year
2014
Language
en
Edition
1
Series
Wiley Series in Protein and Peptide Science
Page amount
288 pages
Category
Technology, Energy, Traffic
Format
Ebook
eISBN (PDF)
9781118855034
Printed ISBN
9781118448526

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