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Owen, Joel S.

Introduction to Population Pharmacokinetic / Pharmacodynamic Analysis with Nonlinear Mixed Effects Models

Owen, Joel S. - Introduction to Population Pharmacokinetic / Pharmacodynamic Analysis with Nonlinear Mixed Effects Models, ebook

109,35€

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ISBN: 9781118784617
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This book provides a user-friendly, hands-on introduction to the Nonlinear Mixed Effects Modeling (NONMEM) system, the most powerful tool for pharmacokinetic / pharmacodynamic analysis.
• Introduces requisite background to using Nonlinear Mixed Effects Modeling (NONMEM), covering data requirements, model building and evaluation, and quality control aspects
• Provides examples of nonlinear modeling concepts and estimation basics with discussion on  the model building process and applications of empirical Bayesian estimates in the drug development environment
• Includes detailed chapters on data set structure, developing control streams for modeling and simulation, model applications, interpretation of NONMEM output and results, and quality control
• Has datasets, programming code, and practice exercises with solutions, available on a supplementary website

Keywords: Drug Discovery & Development, Pharmacokinetic, pharmacodynamic, PK/PD, PK/PD analysis, NONMEM, nonlinear mixed effects modeling, population model, pharmacometrics, pharmacology, drug development, NM-TRAN control stream, model-based drug development, clinical pharmacology, translational research, quantitative pharmacology

Author(s)
 
Publisher
John Wiley and Sons, Inc.
Publication year
2014
Language
en
Edition
1
Page amount
320 pages
Category
Natural Sciences
Format
Ebook
eISBN (ePUB)
9781118784617
Printed ISBN
9780470582299

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