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Gaffney, Jean

Matrix Metalloproteinase Biology

Gaffney, Jean - Matrix Metalloproteinase Biology, ebook

155,85€

Ebook, ePUB with Adobe DRM
ISBN: 9781118772386
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Printing70 pages with an additional page accrued every 11 hours, capped at 70 pages
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Discussing recent advances in the field of matrix metalloproteinase (MMP) research from a multidisciplinary perspective, Matrix Metalloproteinase Biologyis a collection of chapters written by leaders in the field of MMPs.  The book focuses on the challenges of understanding the mechanisms substrate degradation by MMPs, as well as how these enzymes are able to degrade large, highly ordered substrates such as collagen. All topics addressed are considered in relation to disease progression including roles in cancer metastasis, rheumatoid arthritis and other inflammatory diseases.

The text first provides an overview of MMPs, focusing on the history, the development and failures of small molecule inhibitors in clinical trials, and work with TIMPS, the endogenous inhibitors of MMPs. These introductory chapters establish the foundation for later discussion of the recent progress on the design of different types of inhibitors, including novel antibody based therapeutics. The following section emphasizes research using novel methods to further the study of the MMPs. The third and final section focuses on in vivo research, particularly with respect to cancer models, degradation of the extracellular matrix, and MMP involvement in other disease states.

Written and edited by leaders in the field, Matrix Metalloproteinase Biology addresses the rapidly growth in MMP research, and will be an invaluable resource to advanced students and researchers studying cell and molecular biology.

Keywords:

matrix metalloproteinase biology, MMP, enzymes, substrates, collagen, disease, pathology, cancer metastasis, rheumatoid arthritis, inflammatory diseases, small molecule inhibitor, TIMPS, novel antibody based therapeutics, cell biology, cell and molecular biology

, Cell & Molecular Biology
Editor
 
Publisher
John Wiley and Sons, Inc.
Publication year
2015
Language
en
Edition
1
Page amount
232 pages
Category
Natural Sciences
Format
Ebook
eISBN (ePUB)
9781118772386
Printed ISBN
9781118772287

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