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Valko, Klara

Physicochemical and Biomimetic Properties in Drug Discovery: Chromatographic Techniques for Lead Optimization

Valko, Klara - Physicochemical and Biomimetic Properties in Drug Discovery: Chromatographic Techniques for Lead Optimization, ebook

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ISBN: 9781118770320
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Demonstrating how and why to measure physicochemical and biomimetic properties in early stages of drug discovery for lead optimization, Physicochemical and Biomimetic Properties in Drug Discovery encourages readers to discover relationships between various measurements and develop a sense of interdisciplinary thinking that will add to new research in drug discovery. This practical guide includes detailed descriptions of state-of-the-art chromatographic techniques and uses real-life examples and models to help medicinal chemists and scientists and advanced graduate students apply measurement data for optimal drug discovery.

Keywords: Physical Chemistry of Drugs, chromatography, HPLC, ADME properties, physicochemical properties, biomimetic properties, drug discovery, chromatographic techniques, lead optimization, lipophilicity, solubility, permeability, albumin and IAM stationary phases, acid-base character, absorption and distribution, Abraham Solvation equation, biomimetic chromatographic descriptors, physical chemistry, analytical chemistry, pharmacokinetics, pharmacodynamics

Author(s)
Publisher
John Wiley and Sons, Inc.
Publication year
2014
Language
en
Edition
1
Page amount
450 pages
Category
Medicine, Health Care, Mode
Format
Ebook
eISBN (ePUB)
9781118770320
Printed ISBN
9781118152126

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