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Guarna, Antonio

Peptidomimetics in Organic and Medicinal Chemistry

Guarna, Antonio - Peptidomimetics in Organic and Medicinal Chemistry, ebook

137,00€

Ebook, ePUB with Adobe DRM
ISBN: 9781118683149
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A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands.

Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.

Keywords: Biomolecules (DNA, RNA, Peptides, etc.), Peptidomimetics in Organic and Medicinal Chemistry, Antonio Guarna, Andrea Trabocchi, chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, scaffolds for combinatorial chemistry of peptidomimetics

Author(s)
 
Publisher
John Wiley and Sons, Inc.
Publication year
2013
Language
en
Edition
1
Page amount
312 pages
Category
Natural Sciences
Format
Ebook
eISBN (ePUB)
9781118683149
Printed ISBN
9781119950608

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