Guarna, Antonio
Peptidomimetics in Organic and Medicinal Chemistry
A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands.
Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.
Keywords: Biomolecules (DNA, RNA, Peptides, etc.), Peptidomimetics in Organic and Medicinal Chemistry, Antonio Guarna, Andrea Trabocchi, chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, scaffolds for combinatorial chemistry of peptidomimetics
- Author(s)
- Guarna, Antonio
- Trabocchi, Andrea
- Publisher
- John Wiley and Sons, Inc.
- Publication year
- 2013
- Language
- en
- Edition
- 1
- Page amount
- 312 pages
- Category
- Natural Sciences
- Format
- Ebook
- eISBN (ePUB)
- 9781118683149
- Printed ISBN
- 9781119950608