Lysosomes: Biology, Diseases, and Therapeutics

Discussing recent findings, up-to-date research, and novel strategies, the book integrates perspectives from pharmacology, toxicology, and biochemistry to illustrate the potential of lysosomes in drug discovery and development.

• Explores basic principles and properties of lysosomes that allow them to act as regulators of cell metabolism, therapeutic targets, and sites for activation of drug conjugates
• Discusses the role of lysosomes in metabolism, drug targeting, apoptosis, cancer, aging, inflammation, autophagy, metabolism, toxicity, and membrane repair
• Introduces new pathways in therapeutic development and new mechanisms in drug development

Keywords: Lysosomes; lysosome biogenesis; lysosomal accumulation; lysosomal sequestration; lysosomal pathway; autophagy; amino acid sensing; drug induced toxicity; protein trafficking; neurodegeneration; lysosomotropic, Clinical Pharmacology & Therapeutics, Cell & Molecular Biology, Clinical Pharmacology & Therapeutics, Cell & Molecular Biology