The emerging understanding of age-related neurological disorders suggeststhat notions of a single causal gene/toxin being responsible is likely incorrect. Neurological disorders likely arise due to a unique intersection of multiple genetic and toxic factors combined with additional contributions of age, stage of development, immune system actions, and more. This perspective leads to the view that rather than reflecting only one pathway to end state disease, each is a spectrum disorder and each individual case is therefore unique.
Neural Dynamics of Neurological Disease argues for a fundamental rethinking of what we think we know about neurological disorders, how these arise and progress and, crucially, what might be done to “cure” them. Chapters first introduce the concept of neural dynamics of neurological disease, then examine various diseases and give examples of the interplay of elements such as neural systems, cell types, and biochemical pathways which can contribute to disease. Concluding chapters point the way forward to how the emerging notion of neurological disease as a dynamic process may lead to more successful treatment options.
Providing a cross disciplinary approach to understanding the origin and progression of neurological disease, Neural Dynamics of Neurological Disease is a timely and valuable resource for neuroscientists, researchers and clinicians.
About the Author
Christopher A. Shaw Department of Ophthalmology and Visual Sciences, University of British Columbia, Canada
Keywords: neurodegeneration, gene-toxin interactions, environmental toxins, ALS, Parkinson’s Disease, Alzheimer’s Disease, ALS-PDC, Developmental CNS disorders, Model systems, Neurological disease prevention and prophylaxis, Neuroscience