Trabocchi, Andrea
Diversity-Oriented Synthesis: Basics and Applications in Organic Synthesis, Drug Discovery, and Chemical Biology
Discover an enhanced synthetic approach to developing and screening chemical compound libraries
Diversity-oriented synthesis is a new paradigm for developing large collections of structurally diverse small molecules as probes to investigate biological pathways. This book presents the most effective methods in diversity-oriented synthesis for creating small molecule collections. It offers tested and proven strategies for developing diversity-oriented synthetic libraries and screening methods for identifying ligands. Lastly, it explores some promising new applications based on diversity-oriented synthesis that have the potential to dramatically advance studies in drug discovery and chemical biology.
Diversity-Oriented Synthesis begins with an introductory chapter that explores the basics, including a discussion of the relationship between diversity-oriented synthesis and classic combinatorial chemistry. Divided into four parts, the book:
- Offers key chemical methods for the generation of small molecules using diversity-oriented principles, including peptidomimetics and macrocycles
- Expands on the concept of diversity-oriented synthesis by describing chemical libraries
- Provides modern approaches to screening diversity-oriented synthetic libraries, including high-throughput and high-content screening, small molecule microarrays, and smart screening assays
- Presents the applications of diversity-oriented synthetic libraries and small molecules in drug discovery and chemical biology, reporting the results of key studies and forecasting the role of diversity-oriented synthesis in future biomedical research
This book has been written and edited by leading international experts in organic synthesis and its applications. Their contributions are based on a thorough review of the current literature as well as their own firsthand experience developing synthetic methods and applications.
Clearly written and extensively referenced, Diversity-Oriented Synthesis introduces novices to this highly promising field of research and serves as a springboard for experts to advance their own research studies and develop new applications.
Keywords: Organic Chemistry, Diversity-Oriented Synthesis, Molecular Diversity, Multicomponent Reactions, Cycloaddition Reactions, Phosphine Organocatalysis, Domino Reactions in Library Synthesis, Diversity Generation in Drug Discovery, Natural Product-Based Libraries, DNA-Encoded Chemical Libraries, Small-Molecule Microarrays, High-Throughput Screening of Small Molecule Libraries, Virtual Screening
- Author(s)
- Trabocchi, Andrea
- Schreiber, Stuart L.
- Publisher
- John Wiley and Sons, Inc.
- Publication year
- 2013
- Language
- en
- Edition
- 1
- Page amount
- 664 pages
- Category
- Medicine, Health Care, Mode
- Format
- Ebook
- eISBN (ePUB)
- 9781118618141
- Printed ISBN
- 9781118145654