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Lachin, John M.

Randomization in Clinical Trials: Theory and Practice

Lachin, John M. - Randomization in Clinical Trials: Theory and Practice, ebook

143,60€

Ebook, PDF with Adobe DRM
ISBN: 9780471654070
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A unique overview that melds the concepts of conditional probability and stochastic processes into real-life applications

The role of randomization techniques in clinical trials has become increasingly important. This comprehensive guide combines both the applied aspects of randomization in clinical trials with a probabilistic treatment of properties of randomization. Taking an unabashedly non-Bayesian and nonparametric approach to inference, the book focuses on the linear rank test under a randomization model, with added discussion on likelihood-based inference as it relates to sufficiency and ancillarity. Developments in stochastic processes and applied probability are also given where appropriate. Intuition is stressed over mathematics, but not without a clear development of the latter in the context of the former.

Providing a consolidated review of the field, the book includes relevant and practical discussions of:

* The benefits of randomization in terms of reduction of bias

* Randomization as a basis for inference

* Covariate-adaptive and response-adaptive randomization

* Current philosophies, controversies, and new developments

With ample problem sets, theoretical exercises, and short computer simulations using SAS, Randomization in Clinical Trials: Theory and Practice is equally useful as a standard textbook in biostatistics graduate programs as well as a reliable reference for biostatisticians in practice.

Keywords: MATHEMATICS / Probability & Statistics / General MAT029000

Author(s)
 
Publisher
John Wiley and Sons, Inc.
Publication year
2004
Language
en
Edition
1
Category
Natural Sciences
Format
Ebook
eISBN (PDF)
9780471654070
Printed ISBN
9780471236269

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