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Cooper, Matthew

Label-Free Technologies For Drug Discovery

Cooper, Matthew - Label-Free Technologies For Drug Discovery, ebook

148,80€

Ebook, ePUB with Adobe DRM
ISBN: 9781119990277
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Printing98 pages with an additional page accrued every 8 hours, capped at 98 pages
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Over the past two decades the benefits of label-free biosensor analysis have begun to make an impact in the market, and systems are beginning to be used as mainstream research tools in many drug discovery laboratories.

Label-Free Technologies For Drug Discovery summarises the latest and emerging developments in label-free detection systems, their underlying technology principles and end-user case studies that reveal the power and limitations of label-free in all areas of drug discovery.

Label-free technologies discussed include SPR, NMR, high-throughput mass spectrometry, resonant waveguide plate-based screening, transmitted-light imaging, isothermal titration calorimetry, optical and impedance cell-based assays and other biophysical methods. The technologies are discussed in relation to their use as screening technologies, high-content technologies, hit finding and hit validation strategies, mode of action and ADME/T, access to difficult target classes, cell-based receptor/ligand interactions particularly orphan receptors, and antibody and small molecule affinity and kinetic analysis.

Label-Free Technologies For Drug Discovery is an essential guide to this emerging class of tools for researchers in drug discovery and development, particularly high-throughput screening and compound profiling teams, medicinal chemists, structural biologists, assay developers, ADME/T specialists, and others interested in biomolecular interaction analysis.

Keywords: label-free technologies, drug discovery, drug development, analytical chemistry, label-free detecion systems, high-throughput screening, compound profiling teams, biomolecular interaction analysis

Author(s)
 
Publisher
John Wiley and Sons, Inc.
Publication year
2010
Language
en
Edition
1
Page amount
328 pages
Category
Medicine, Health Care, Mode
Format
Ebook
eISBN (ePUB)
9781119990277
Printed ISBN
9780470746837

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