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Foundation, Novartis

Cancer and Inflammation

Foundation, Novartis - Cancer and Inflammation, ebook

163,70€

Ebook, PDF with Adobe DRM
ISBN: 9780470856727
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Printing87 pages with an additional page accrued every 9 hours, capped at 87 pages
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Chronic inflammation predisposes to some forms of cancer and the host response to malignant disease shows several parallels with inflammation and wound healing. The cells involved in inflammation are detected in a range of common cancers, together with the inflammatory cytokines and members of the chemokine ligand/receptor systems.

Neutralization or deletion of the gene for some inflammatory cytokines confers resistance to tumour induction and experimental metastasis. Over-expression of such cytokines in tumour cells may enhance malignant potential. Certain chemokines are likely to subvert antitumour immunity by favouring development of ineffective Type 2 responses. Tumour cells may even utilize chemokine receptors in homing to lymph nodes and other organs. Thus, the cells, cytokines and chemokines found in tumours are more likely to contribute to tumour growth, progression and immunosuppression than they are to mount an effective host antitumour response.

This book draws together contributions from an international group of scientists and clinicians from diverse disciplines, ranging from epidemiology to immunology, cell biology, molecular oncology, molecular medicine and pharmacology to debate these and related issues. Topics covered include the epidemiological links between cancer and inflammation, the parallels between inflammation and cancer, the role of inflammation in cancer, inflammatory genes as risk factors for cancer initiation and progression, inflammation and cancer angiogenesis, and preventative and therapeutic strategies.

Related Novartis Foundation symposia:

252 Generation and Effector Functions of Regulatory Lymphocytes

Chair: Jean-François Bach

254 Immunoinformatics: Bioinformatic Strategies for Better Understanding of Immune Function

Chair: Hans-Georg Rammensee

Keywords: SCIENCE / Life Sciences / Biochemistry SCI007000

Author(s)
Publisher
John Wiley and Sons, Inc.
Publication year
2004
Language
en
Edition
1
Series
Novartis Foundation Symposia
Page amount
290 pages
Category
Natural Sciences
Format
Ebook
eISBN (PDF)
9780470856727
Printed ISBN
9780470855102

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