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Harrington, Peter J.

Pharmaceutical Process Chemistry for Synthesis: Rethinking the Routes to Scale-Up

Harrington, Peter J. - Pharmaceutical Process Chemistry for Synthesis: Rethinking the Routes to Scale-Up, ebook

162,20€

Ebook, ePUB with Adobe DRM
ISBN: 9780470922866
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Printing134 pages with an additional page accrued every 6 hours, capped at 134 pages
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There is aneed to explain that generic versions of a drug may not be manufactured by the same process as brand-name drugs and that the different processes may have dramatically different environmental impacts. Two global forces are at odds today—the push for "greener" processes and the push for lower drug prices. This book brings this conflict into sharp focus by discussing in detail the published process chemistry for top-selling small molecule drugs.

Providing insights about process route selection, choice of reagents, and reaction conditions, Pharmaceutical Process Chemistry for Synthesis guides process chemists in identifying best processes for manufacturing these blockbuster drugs as they lose patent protection. Further, it highlights the strategies and methodology that might be useful for expediting the process research and development of the blockbusters of the future.

Written from a refreshingly objective perspective, this book is essential for process chemists who need to devise practical syntheses for increasingly complex drugs in a constantly decreasing time frame.

Keywords: Process chemistry, process chemistry and practical syntheses for complex drugs, process chemistry and cost, process chemistry and safety, process chemistry and efficiency, process chemistry and environmental impact, Pharmaceutical & Medicinal Chemistry, Process Development, Pharmaceutical & Medicinal Chemistry, Process Development

Author(s)
Publisher
John Wiley and Sons, Inc.
Publication year
2011
Language
en
Edition
1
Page amount
376 pages
Category
Natural Sciences
Format
Ebook
eISBN (ePUB)
9780470922866
Printed ISBN
9780470577554

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