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Han, Chao

Evaluation of Drug Candidates for Preclinical Development: Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology

Han, Chao - Evaluation of Drug Candidates for Preclinical Development: Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology, ebook

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ISBN: 9780470574881
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Explaining the assessment of potential drug compounds, this is an ideal introductory reference for those new to drug discovery. It includes sections on pharmacokinetics and drug metabolism, integration of pharmaceutical development, and predictive safety assessment. Topics include: cost analysis, drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, assessing stability, ways to optimize drug formulation, toxicology and toxicokinetics, and more. Readers will understand why absorption-distribution-metabolism-excretion-toxicology (ADMET) is key in drug development. This is an enlightening reference for scientists, medicinal chemists, and others working in drug discovery.

Keywords: Charles Davis, evaluation of drug candidates, assessment of drug candidates, evaluation of potential drug compounds, assessment of potential drug compounds, ADMET, drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, assessing stability, optimizing drug formulation, toxicology, toxicokinetics

Author(s)
 
 
Publisher
John Wiley and Sons, Inc.
Publication year
2010
Language
en
Edition
1
Series
Wiley Series in Drug Discovery and Development
Page amount
256 pages
Category
Medicine, Health Care, Mode
Format
Ebook
eISBN (PDF)
9780470574881
Printed ISBN
9780470044919

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