This book reviews advances in understanding phosphodiesterases within the central nervous system and theirtherapeutic applications. A range of expert authors from both academia and industry describe these, then focus on the areas of greatest scientific and medical interest to provide more detailed coverage. Therapeutic and drug discovery applications are covered for diseasesincluding Alzheimer's, Parkinson's, schizophrenia, erectile dysfunction, and spinal cord injuries. There is also a chapter on drug discovery tools such as in vitro assays and X-ray structures for medicinal chemistry studies.
Keywords: phosphodiesterases, cyclic nucleotides, central nervous system, cyclic GMP, cyclic AMP, drug discovery tools, vitro assays, Alzheimer's, Parkinson's, schizophrenia, erectile dysfunction, spinal cord injuries, Neuroscience, Pharmacology & Pharmaceutical Medicine, Neuroscience, Pharmacology & Pharmaceutical Medicine