Dynamic Combinatorial Chemistry
In Drug Discovery, Bioorganic Chemistry, and Materials Science
Benjamin L. Miller
Effective techniques for applying Dynamic Combinatorial Chemistry
In a relatively short period, Dynamic Combinatorial Chemistry (DCC) has grown from proof-of-concept experiments in a few isolated labs to a broad conceptual framework with applications to an exceptional range of problems in molecular recognition, lead compound identification, catalyst design, nanotechnology, polymer science, and others. Bringing together a group of respected experts, this overview explains how chemists can apply DCC and fragment-based library methods to lead generation for drug discovery and molecular recognition in bioorganic chemistry and materials science.
Approaches to binding in proteins and nucleic acids
Analytical chemistry challenges
A comprehensive, single-source reference about DCC methods and applications including aspects of fragment-based drug discovery, this is a core reference that will spark the development of new solutions and strategies for chemists building structure libraries and designing compounds and materials.
Keywords: dynamic combinatorial chemistry, DCC, fragment-based library methods, molecular recognition, catalyst discovery, click chemistry, SAR by NMR, fragment-based drug discovery, DCC methods, DCC applications