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Miller, Benjamin L.

Dynamic Combinatorial Chemistry : In Drug Discovery, Bioorganic Chemistry, and Materials Science

Miller, Benjamin L. - Dynamic Combinatorial Chemistry : In Drug Discovery, Bioorganic Chemistry, and Materials Science, ebook

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Dynamic Combinatorial Chemistry

In Drug Discovery, Bioorganic Chemistry, and Materials Science

Edited by

Benjamin L. Miller

Effective techniques for applying Dynamic Combinatorial Chemistry

In a relatively short period, Dynamic Combinatorial Chemistry (DCC) has grown from proof-of-concept experiments in a few isolated labs to a broad conceptual framework with applications to an exceptional range of problems in molecular recognition, lead compound identification, catalyst design, nanotechnology, polymer science, and others. Bringing together a group of respected experts, this overview explains how chemists can apply DCC and fragment-based library methods to lead generation for drug discovery and molecular recognition in bioorganic chemistry and materials science.

Chapters cover:

  • Basic theory

  • Approaches to binding in proteins and nucleic acids

  • Molecular recognition

  • Self-sorting

  • Catalyst discovery

  • Materials discovery

  • Analytical chemistry challenges


A comprehensive, single-source reference about DCC methods and applications including aspects of fragment-based drug discovery, this is a core reference that will spark the development of new solutions and strategies for chemists building structure libraries and designing compounds and materials.

Keywords: dynamic combinatorial chemistry, DCC, fragment-based library methods, molecular recognition, catalyst discovery, click chemistry, SAR by NMR, fragment-based drug discovery, DCC methods, DCC applications

Author(s)
Publisher
John Wiley and Sons, Inc.
Publication year
2010
Language
en
Edition
1
Page amount
240 pages
Category
Natural Sciences
Format
Ebook
eISBN (PDF)
9780470551547
Printed ISBN
9780470096031

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