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Foundation, Novartis

Decoding the Genomic Control of Immune Reactions: Novartis Foundation Symposium

Foundation, Novartis - Decoding the  Genomic Control of Immune Reactions: Novartis Foundation Symposium, ebook

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ISBN: 9780470062111
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This book explores existing and potential strategies for using the genome sequences of human, mouse, other vertebrates and human pathogens to solve key problems in the treatment of immunological diseases and chronic infections.  The assembled genome sequences now provide important opportunities for solving these problems, but a major bottleneck is the identification of key sequences and circuits controlling the relevant immune reactions. This will require innovative, interdisciplinary and collaborative strategies of a scale and complexity we are only now beginning to comprehend.


Specific problems addressed include the following:


  • What kinds of information are we lacking to understand how the genome sequence specifies the differentiation and response of immune system cells, and system behaviour such as immunological memory and tolerance?
  • Which genome sequences and cellular circuits cause or prevent pathological immune responses to foreign pathogens, allergens or self-tissues?
  • Which host and pathogen genome sequences and cellular circuits explain the failure of sterilizing immune responses to sophisticated human pathogens such as the agents of tuberculosis, malaria, metazoan parasites and chronic viruses?


Containing contributions from a range of leading experts in the field, this book provides an important new perspective for clinical immunologists and basic researchers alike.

Keywords: MEDICAL / Immunology MED044000

Author(s)
Publisher
John Wiley and Sons, Inc.
Publication year
2007
Language
en
Edition
1
Series
Novartis Foundation Symposia
Page amount
232 pages
Category
Medicine, Health Care, Mode
Format
Ebook
eISBN (PDF)
9780470062111
Printed ISBN
9780470027554

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