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Foundation, Novartis

The hERG Cardiac Potassium Channel: Structure, Function and Long QT Syndrome, Novartis Foundation Symposium

Foundation, Novartis - The hERG Cardiac Potassium Channel: Structure, Function and Long QT Syndrome, Novartis Foundation Symposium, ebook

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ISBN: 9780470021415
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This book draws together contributions from basic, pharmaceutical and clinical sciences aimed at a better understanding of the structure and function of hERG and the molecular basis for compound binding. 

It features regulatory authority perspectives on preferred preclinical test systems and includes topics on hERG channel gating, regulation of functional expression, pharmacological properties of hERG/IKr channels, drug-induced long QT syndrome and preclinical evaluation and regulatory recommendations for assessing QT prolongation risks. 

Better understanding of the role of the hERG channel in drug-induced cardiac arrhythmias should ultimately lead to the development of important, new and safer medicines.

Keywords: SCIENCE / Life Sciences / Biochemistry SCI007000

Author(s)
Publisher
John Wiley and Sons, Inc.
Publication year
2005
Language
en
Edition
1
Series
Novartis Foundation Symposia
Page amount
308 pages
Category
Natural Sciences
Format
Ebook
eISBN (PDF)
9780470021415
Printed ISBN
9780470021408

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