Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics

Part I. Basic Concepts and Principles

1. Introduction to Pharmacodynamics
William A. Craig

2. In Vitro and Animal PK/PD Models
William A. Craig

3. Setting Clinical MIC Breakpoints from a PK/PD Point of View: It Is the Dose That Matters
Johan W. Mouton

4. Principles of Applied Pharmacokinetic–Pharmacodynamic Modeling
Benjamin Wu, Sherwin K. B. Sy, Hartmut Derendorf

5. Pharmacodynamic In Vitro Models to Determine the Effect of Antibiotics
Julia Michael, Aline Barth, Charlotte Kloft, Hartmut Derendorf

6. Population Pharmacokinetic–Pharmacodynamic (PK/PD) Modeling of Anti-infective Agents and Its Applications to Individualized Therapy
Alexander A. Vinks

7. Suppressing Resistance Development
Vincent H. Tam

8. Drug–Drug Combinations
John Turnidge

Part II. Clinically Oriented Chapters

9. Aminoglycosides
Catharine C. Bulik, Charles H. Nightingale, David P. Nicolau

10. Continuous Infusion of Beta-lactam Antibiotics
Anouk E. Muller, Johan W. Mouton

11. Macrolides and Ketolides
Françoise Bambeke

12. Glycopeptides
Inge C. Gyssens

13. Clinical Pharmacodynamics of Quinolones
George L. Drusano, H. S. Heine, A. Louie

14. Pharmacokinetics and Pharmacodynamics of Colistin
Roger L. Nation, Phillip J. Bergen, Jian Li

15. Daptomycin: Pharmacokinetic, Pharmacodynamic, and Dose Optimization
Céline Vidaillac, Michael J. Rybak

16. PK/PD of Oxazolidinones
Ursula Theuretzbacher

17. Tigecycline
Catharine C. Bulik, Anthony M. Nicasio, Paul G. Ambrose

Keywords: Medicine & Public Health, Infectious Diseases, Pharmacology/Toxicology, Immunology, Medical Microbiology, Public Health