evaluating clinical research

1. What is the purpose of this book?
Bengt D. Furberg, Curt D. Furberg

2. Why is benefit-to-harm balance essential to treatment decisions?
Bengt D. Furberg, Curt D. Furberg

3. What are the strengths of randomized controlled clinical trials?
Bengt D. Furberg, Curt D. Furberg

4. What are the weaknesses of randomized controlled clinical trials?
Bengt D. Furberg, Curt D. Furberg

5. Do meta-analyses provide the ultimate truth?
Bengt D. Furberg, Curt D. Furberg

6. What are the strengths of observational studies?
Bengt D. Furberg, Curt D. Furberg

7. What are the weaknesses of observational studies?
Bengt D. Furberg, Curt D. Furberg

8. Were the scientific questions stated in advance?
Bengt D. Furberg, Curt D. Furberg

9. Were the treatment groups comparable initially?
Bengt D. Furberg, Curt D. Furberg

10. Why is blinding/masking so important?
Bengt D. Furberg, Curt D. Furberg

11. How is symptomatic improvement measured?
Bengt D. Furberg, Curt D. Furberg

12. Is it really possible to assess quality of life?
Bengt D. Furberg, Curt D. Furberg

13. What is the value of biologic markers in drug evaluation?
Bengt D. Furberg, Curt D. Furberg

14. How are adverse drug reactions measured?
Bengt D. Furberg, Curt D. Furberg

15. How representative are study subjects in clinical trials?
Bengt D. Furberg, Curt D. Furberg

16. What happened to the study subjects who disappeared from the analysis?
Bengt D. Furberg, Curt D. Furberg

17. How reliable are active-control trials?
Bengt D. Furberg, Curt D. Furberg

18. How informative are composite outcomes?
Bengt D. Furberg, Curt D. Furberg

19. Do changes in biologic markers predict clinical benefit?
Bengt D. Furberg, Curt D. Furberg

20. How trustworthy are the authors?
Bengt D. Furberg, Curt D. Furberg

21. Does publication in a reputable scientific journal guarantee quality?
Bengt D. Furberg, Curt D. Furberg

22. Is it necessary to be a biostatistician to interpret scientific data?
Bengt D. Furberg, Curt D. Furberg

23. Are all drugs of a class interchangeable?
Bengt D. Furberg, Curt D. Furberg

24. How much confidence can be placed on economic analysis?
Bengt D. Furberg, Curt D. Furberg

25. How should I handle the massive flow of information?
Bengt D. Furberg, Curt D. Furberg

26. How well is research translated into clinical care?
Bengt D. Furberg, Curt D. Furberg

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Keywords: MATHEMATICS / Probability & Statistics / General MAT029000