Advances in Alzheimer’s and Parkinson’s Disease

1. Clinical Features and Treatment of Dementia Associated With Parkinson’s Disease
Murat Emre

2. Neurogenetics in Parkinson's Disease
Yoshikuni Mizuno, Nobutaka Hattori

3. Impaired DNA Repair Systems: Generation of Mitochondrial Dysfunction and Increased Sensitivity to Excitotoxicity
Simona Francisconi, Mara Codenotti, Erminia Poli, Daniela Uberti, Giulia Ferrari-Toninelli, Maurizio Memo

4. Current Problems and Strategies in Motor Rehabilitation for Parkinson’s Disease
Giovanni Abbruzzese, Elisa Pelosin, Roberta Marchese

5. Critical Acute Akinesia in Parkinson’s Disease Patients Concomitant with Additional Precipitating Factors Other Than Treatment Withdrawal: A Possible Lethal Complication
Marco Onofrj, Astrid Thomas

6. Biomarkers for Early Detection of Parkinson’s Disease: An Essential Challenge
Florian Tribl, Peter Riederer

7. Neurotransmitter and Neurotrophic Factor-Secreting Cell Line Grafting for the Treatment of Parkinson’s Disease
Isao Date, Tetsuro Shingo, Takao Yasuhara

8. Novel Therapeutic Target in PD: Experimental Models
Francesco Fornai

9. LRRK2 (Leucine-Rich Repeat Kinase 2) Gene on PARK8 Locus in Families with Parkinsonism
Zbigniew K. Wszolek, Alexander Zimprich, Saskia Biskup, Ryan J. Uitti, Donald B. Calne, A. Jon Stoessl, Akiko Imamura, Matthew J. Farrer, Judith Miklossy, Thomas Meitinger, Thomas Gasser, Dennis W. Dickson, Patrick L. McGeer

10. Microglia Activation and Gene Expression of Cytokines in Parkinson’s Disease
Makoto Sawada, Kazuhiro Imamura, Toshiharu Nagatsu

11. Dissecting the Biochemical Pathways Mediated by Genes Implicated in Parkinson’s Disease: Induction of DJ-1 Expression in A30P a-Synuclein Mice
Mark Frasier, Shanti Frausto, Daniel Lewicki, Lawrence Golbe, Benjamin Wolozin

12. Neuroinflammation in Early Stages of Alzheimer’s Disease and Parkinson’s Disease
Piet Eikelenboom, A. Crosswell, C. van Engen, M. Limper, J.J.M. Hoozemans, R. Veerhuis, W.A. van Gool, J.M. Rozemuller

13. Alzheimer’s Disease, Parkinson’s Disease, and Frontotemporal Dementias: Different Manifestations of Protein Misfolding
John Q. Trojanowski, Mark S. Forman, Virginia M-Y. Lee

14. Role of Oxidative Insult and Neuronal Survival in Alzheimer’s and Parkinson’s Diseases
Akihiko Nunomura, Paula I. Moreira, Xiongwei Zhu, Adam D. Cash, Mark A. Smith, George Perry

15. Redox Proteomics Identification of Oxidatively Modified Proteins in Alzheimer’s Disease Brain and in Brain from a Rodent Model of Familial Parkinson’s Disease: Insights into Potential Mechanisms of Neurodegeneration
Rukhsana Sultana, H. Fai Poon, D. Allan Butterfield

16. Biomarkers for Alzheimer’s Disease and Parkinson’s Disease
John H. Growdon, Michael C. Irizarry, Clemens Scherzer

17. Bioluminescent Imaging of Excitotoxic and Endotoxic Brain Injury in Living Mice
Jian Luo, Amy H. Lin, Tony Wyss-Coray

18. Alzheimer’s Disease Neuroimaging Initiative
Susanne G. Mueller, Michael W. Weiner, Leon J. Thal, Ronald C. Petersen, Clifford Jack, William Jagust, John Q. Trojanowski, Arthur W Toga, Laurel Beckett

19. Two Hits and You’re Out? A Novel Mechanistic Hypothesis of Alzheimer Disease
Xiongwei Zhu, George Perry, Mark A. Smith

20. Vascular Risk Factors and Risk for Alzheimer’s Disease and Mild Cognitive Impairment: Population-Based Studies
Hilkka Soininen, Miia Kivipelto, Aulikki Nissinen

21. Cholesterol Transport and Production in Alzheimer’s Disease
Judes Poirier, Louise Lamarre-Théroux, Doris Dea, Nicole Aumont, Jean Francois Blain

22. Cholesterol and Aß Production: Methods for Analysis of Altered Cholesterol De Novo Synthesis
Jakob A. Tschäpe, Marcus O.W. Grimm, Heike S. Grimm, Tobias Hartmann

23. Glycosaminoglycans and Analogs in Neurodegenerative Disorders
Lucilla Parnetti, Umberto Cornelli

24. Prospective Role of Glycosaminoglycans in Apoptosis Associated with Neurodegenerative Disorders
Bertalan Dudas, Amira Lemes, Umberto Cornelli, Israel Hanin

25. Stem Cell Therapy in Alzheimer’s Disease
Kiminobu Sugaya, Young-Don Kwak, Angel Alvarez

26. Oral Aß Vaccine Using a Recombinant Adeno-Associated Virus Vector in an Alzheimer’s Disease Mouse Model
Takeshi Tabira, Hideo Hara

27. In Vivo Targeting of Amyloid Plaques Via Intranasal Administration of Phage Anti-ß-Amyloid Antibodies
Beka Solomon

28. Decreased ProBDNF: The Cause of Alzheimer’s-Associated Neurodegeneration and Cognitive Decline?
Margaret Fahnestock, S. Peng, D.J. Garzon, Elliott J. Mufson

29. Shift in the Balance of TRKA and ProNGF in Prodromal Alzheimer ’s Disease
Elliott J. Mufson, Scott E. Counts, S. Peng, Margaret Fahnestock

30. Neuroprotective Effects of Trophic Factors and Natural Products: Involvement of Multiple Intracellular Kinases
Stéphane Bastianetto, Wen-Hua Zheng, Yingshan Han, Lixia Gan, Rémi Quirion

31. Intraneuronal Aß and Alzheimer’s Disease
Lauren M. Billings, Frank M. LaFerla

32. Physiological Processing of the Cellular Prion Protein and ßAPP: Enzymes and Regulation
Bruno Vincent, Moustapha Alfa Cisse, Frédéric Checler

33. Expression of Wnt Receptors, Frizzled, in Rat Neuronal Cells
Marcelo A. Chacón, Marcela Columbres, Nibaldo C. Inestrosa

34. Cell Models of Tauopathy
J. Biernat, I. Khlistunova, Y-P. Wang, M. Pickhardt, M. von Bergen, Z. Gazova, Eckhart Mandelkow, Eva-Marie Mandelkow

35. Co-expression of FTDP-17 Human Tau and GSK-3ß (or APPSW) in Transgenic Mice: Induction of Tau Polymerization and Neurodegeneration
Jesús Avila, Tobias Engel, José J. Lucas, Mar Pérez, Alicia Rubio, Félix Hernández

36. Enhanced Activation of NF-?B Signaling by Apolipoprotein E4
Gal Ophir, Liza Mizrahi, Daniel M. Michaelson

37. Pleiotropic Effects of Apolipoprotein E in Dementia: Influence on Functional Genomics and Pharmacogenetics
Ramón Cacabelos

38. Up-regulation of the a-Secretase Pathway
Falk Fahrenholz, Claudia Prinzen, Rolf Postina, Elzbieta Kojro

39. Frequency and Relation of Argyrophilic Grain Disease and Thorn-Shaped Astrocytes in Alzheimer’s Disease
Hirotake Uchikado, Yasuhiro Fujino, Wenlang Lin, Dennis Dickson

40. Cellular Membranes as Targets in Amyloid Oligomer Disease Pathogenesis
Erene W. Mina, Charles G. Glabe

41. Ganglioside-Dependent Generation of a Seed for Alzheimer’s Disease Amyloid
Katsuhiko Yanagisawa

42. Evidence That Amyloid Pathology Progresses in a Neurotransmitter-Specific Manner
Karen F.S. Bell, A. Claudio Cuello

43. Rationale for Glutamatergic and Cholinergic Approaches for the Treatment of Alzheimer’s Disease
Paul T. Francis, Sara L. Kirvell

44. Cortical Cholinergic Lesion Causes Aß Deposition: Cholinergic-Amyloid Fusion Hypothesis
Thomas Beach, Pamela Potter, Lucia Sue, Amanda Newell, Marissa Poston, Raquel Cisneros, Yoga Pandya, Abraham Fisher, Alex Roher, Lih-Fen Lue, Douglas Walker

45. Expression of Acetylcholinesterase in Alzheimer’s Disease Brain: Role in Neuritic Dystrophy and Synaptic Scaling
David H. Small, Steven Petratos, Sharon Unabia, Danuta Maksel

46. Role of b-Amyloid in the Pathophysiology of Alzheimer’s Disease and Cholinesterase Inhibition: Facing the Biological Complexity to Treat the Disease
Stefano Govoni, Michela Mazzucchelli, S. Carolina Lenzken, Emanuela Porrello, Cristina Lanni, Marco Racchi

47. Dissociation Between the Potent ß-Amyloid Protein Pathway Inhibition and Cholinergic Actions of the Alzheimer Drug Candidates Phenserine and Cymserine
Nigel H. Greig, Tada Utsuki, Qian-sheng Yu, Harold W. Holloway, Tracyann Perry, David Tweedie, Tony Giordano, George M. Alley, De-Mao Chen, Mohammad A. Kamal, Jack T. Rogers, Kumar Sambamurti, Debomoy K. Lahiri

48. Allosteric Potentiators of Neuronal Nicotinic Cholinergic Receptors: Potential Treatments for Neurodegenerative Disorders
Emanuele Sher, Giovanna De Filippi, Tristan Baldwinson, Ruud Zwart, Kathy H. Pearson, Martin Lee, Louise Wallace, Gordon I. McPhie, Martine Keenan, Renee Emkey, Sean P. Hollinshead, Colin P. Dell, S. Richard Baker, J. Michael O’Neil, Lisa M. Broad

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Keywords: TECHNOLOGY & ENGINEERING / Biomedical TEC059000