Pharmacological Mechanisms in Alzheimer's Therapeutics

1. Overview of the Alzheimer's Disease Pathology and Potential Therapeutic Targets
A. Claudio Cuello

2. Trial Designs and Outcomes to Monitor Novel Therapeutics in Alzheimer's Disease
Serge Gauthier

3. The Pharmacological Treatment of Alzheimer's Disease with Cholinesterase Inhibitors and Memantine
Gordon Keith Wilcock

4. M1 Muscarinic Agonists: A Comprehensive Therapy Against Major Hallmarks of Alzheimer's Disease
Abraham Fisher

5. Cholinergic Neurodegeneration in Alzheimer's Disease: Basis for Nerve Growth Factor Therapy
Ahmad Salehi, Alexander Kleshevnikov, William C. Mobley

6. The Rationale for Glutamatergic Therapy in Alzheimer's Disease
Paul T. Francis

7. Secretases as Pharmacological Targets in Alzheimer's Disease
Nigel M. Hooper, Emma R. L. C. Vardy

8. ?-Secretase as a Target for Alzheimer's Disease
Michael S. Wolfe

9. The Rationale for an Immunological Approach to Alzheimer's Therapeutics
Dave Morgan

10. Neuroinflammation, Alzheimer Disease, and Other Aging Disorders
Edith G. McGeer, Patrick L. McGeer

11. Nonsteroidal Anti-inflammatory Drugs (NSAIDs) and Derived Aß42-Lowering Molecules for Treatment and Prevention of Alzheimer's Disease (AD)
Sascha Weggen, Eva Czirr, Stefanie Leuchtenberger, Jason Eriksen

12. The Potential Application of Antioxidant Agents in Alzheimer Disease Therapeutics
Paula I. Moreira, Mark A. Smith, Xiongwei Zhu, Akihiko Nunomura, George Perry

13. Apolipoprotein E: A Potent Gene-Based Therapeutic Target for the Treatment of Sporadic Alzheimer's Disease
Judes Poirier

14. Tau Pathology as a Target in Alzheimer's Therapeutics
Khalid Iqbal, Inge Grundke-Iqbal

15. Design of Inhibitors of Amyloid-ß Misfolding and Aggregation for Alzheimer's Therapy
Lisbell D. Estrada, Cristian Lasagna, Claudio Soto

16. Potential Applications of Glycosaminoglycan-Related Compounds in Alzheimer's Disease
Céline Morissette, Diane Lacombe, Xianqi Kong, Ahmed Aman, Pascale Krzywkowski, Lioudmila Rodionova, Mounia Azzi, Daniel Delorme, Barry D. Greenberg

17. Multifunctional Neuroprotective Drugs for the Treatment of Alzheimer's Disease
Cornelis J. Van der Schyf, Werner J. Geldenhuys, Moussa B. H. Youdim

18. Interpreting Clinical Studies of Putative Therapeutics for Alzheimer's Disease: The Case of Statins and NSAIDs
Benjamin Wolozin

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Keywords: TECHNOLOGY & ENGINEERING / Biomedical TEC059000