Green, Jeffrey E.

Genetically Engineered Mice for Cancer Research

Green, Jeffrey E. - Genetically Engineered Mice for Cancer Research, ebook


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ISBN: 9780387698052
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Table of contents

1. Overview of Designing Genetically Engineered Mouse (GEM) Models
Thomas Doetschman, L. Philip Sanford

2. The Use of Cre–loxP Technology and Inducible Systems to Generate Mouse Models of Cancer
Chu-Xia Deng

3. Using Recombineering Technology to Create Genetically Engineered Mouse Models
Subha Philip, Shyam K. Sharan

4. Insertional Mutagenesis for Generating Mouse Models of Cancer
David A. Largaespada

5. The RCAS/TVA Somatic Gene Transfer Method in Modeling Human Cancer
Yi Li, Andrea Ferris, Brian C. Lewis, Sandra Orsulic, Bart O. Williams, Eric C. Holland, Stephen H. Hughes

6. Target-Selected ENU Mutagenesis to Develop Cancer Models in the Rat
Bart M. G. Smits, Edwin Cuppen, Michael N. Gould

7. The Tumor Pathology of Genetically Engineered Mice: Genomic Pathology
Robert D. Cardiff

8. Genomic DNA Copy Number Alterations in Mouse Cancer Models and Human Cancer
Donna G. Albertson

9. Characterization of Chromosomal Translocations in Mouse Models of Hematological Malignancies Using Spectral Karyotyping, FISH, and Immunocytochemistry
Thomas Ried, Michael J. Difilippantonio

10. Expression Profiling of Mouse Models of Human Cancer: Model Categorization and Guidance for Preclinical Testing
Min Zhu, Aleksandra M. Michalowski, Jeffrey E. Green

11. Imaging Mouse Models of Human Cancer
Jennifer A. Prescher, Christopher H. Contag

12. Identifying Mammary Epithelial Stem and Progenitor Cells
Andrew O. Giacomelli, Robin M. Hallett, John A. Hassell

13. Differentiation Programs in Development and Cancer
Hosein Kouros-Mehr

14. Roles of p53 and pRB Tumor Suppressor Networks in Human Cancer: Insight from Studies in the Engineered Mouse
Julien Sage, Laura Attardi, Terry Dyke

15. Mouse Models for Colorectal Cancer
Melanie Kucherlapati, Ken Hung, Mari Kuraguchi, Raju Kucherlapati

16. Src Family Tyrosine Kinases: Implications for Mammary Tumor Progression
Richard Marcotte, William J. Muller

17. Maspin and Suppression of Tumor Metastasis
Lauren Reinke, Ming Zhang

18. Epigenetic Mouse Models
Cecilia Rosales, Manel Esteller

19. Modeling Transforming Growth Factor-ß Signaling in Cancer
Veronica R. Placencio, Neil A. Bhowmick

20. Modeling Stromal–Epithelial Interactions
Omar E. Franco, Douglas W. Strand, Simon W. Hayward

21. Utilizing Mouse Models of Human Cancer for Assessing Immune Modulation of Cancer Development
Karin E. Visser, Lisa M. Coussens

22. Transplanted Tumor Models for Preclinical Drug Testing and the Potential Benefit of Genetically Engineered Mouse Models
Melinda Hollingshead, Michelle Ahalt, Sergio Alcoser

23. The Development and Use of Genetically Tractable Preclinical Mouse Models
Michael T. Hemann

24. Animal Models for Breast Cancer Prevention Research
Chunyu Wang, Powel H. Brown

25. Oncogene Addiction: Mouse Models and Clinical Relevance for Molecularly Targeted Therapies
James V. Alvarez, Elizabeth S. Yeh, Yi Feng, Lewis A. Chodosh

26. Mouse Models in Preclinical Drug Development: Applications to CNS Models
Eletha Carbajal, Eric C. Holland

27. Mouse Models of Human Cancer: Role in Preclinical Testing and Personalized Medicine
Alice Hawley Berger, Pier Paolo Pandolfi

28. Mighty, But How Useful? The Emerging Role of Genetically Engineered Mice in Cancer Drug Discovery and Development
Reinhard Ebner, Jeffrey W. Strovel, Stephen K. Horrigan, Kenneth C. Carter

Keywords: Biomedicine, Cancer Research, Human Genetics, Laboratory Medicine, Medical Microbiology, Animal Biochemistry, Parasitology

Publication year
Page amount
20 pages
Medicine, Health Care, Mode

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