Solvent Systems and Their Selection in Pharmaceutics and Biopharmaceutics

1. Principles of Solubility
YUCHUAN GONG, DAVID J.W. GRANT, HARRY G. BRITTAIN

2. Ionic Equilibria and the pH Dependence of Solubility
HARRY G. BRITTAIN

3. Solvent Systems for Crystallization and Polymorph Selection
JONATHAN M. MILLER, NAÍR RODRÍGUEZ-HORNEDO, ANTHONY C. BLACKBURN, DAINIUS MACIKENAS, BENJAMIN M. COLLMAN

4. Solubility Issues in Early Discovery and HTS
LI DI, EDWARD H. KERNS

5. Practical Aspects of Solubility Determination in Pharmaceutical Preformulation
WEI-QIN (TONY)TONG

6. Biorelevant Dissolution Media
ANETTE MüLLERTZ

7. Selection of Solvent Systems for Membrane-, Cell- and Tissue-Based Permeability Assessment
FRANÇOISE INGELS, ANNA-LENA UNGELL, PATRICK AUGUSTIJNS

8. The Use of Solubilizing Excipients and Approaches to GenerateToxicology Vehicles for Contemporary Drug Pipelines
MARCUS E. BREWSTER, CLAIRE MACKIE, MARC NOPPE, ANN LAMPO, THORSTEINN LOFTSSON

9. Solubilizing Vehicles for Oral Formulation Development
ROBERT G. STRICKLEY, REZA OLIYAI

10. Solubilizing Systems for Parenteral Formulation Development—Small Molecules
JAMES E. KIPP

11. Aqueous Solubilizing Systems for Parenteral Formulation Development—Proteins
ZAHRA SHAHROKH

12. Non-Aqueous Systems for Formulation Development—Proteins
CYNTHIA L. STEVENSON

13. Pharmaceutical Solvents as Vehicles for Topical Dosage Forms
ADRIAN WILLIAMS

14. Pharmaceutical Solvents for Pulmonary Drug Delivery
ERIK MOGALIAN, PAUL BRIAN MYRDAL

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Keywords: TECHNOLOGY & ENGINEERING / Biomedical TEC059000