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Fink, Anthony L.

Protein Misfolding, Aggregation, and Conformational Diseases

Fink, Anthony L. - Protein Misfolding, Aggregation, and Conformational Diseases, ebook

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ISBN: 9780387365343
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Table of contents

I.Altered Protein Structure and Enhanced Aggregation/Deposition

1. The Pathogenesis of Alzheimer’s Disease: General Overview
Liana G. Apostolova, Jeffrey L. Cummings

2. Free Radicals, Metal Ions, and Aß Aggregation and Neurotoxicity
Kevin J. Barnham, Cyril C. Curtain, Ashley I. Bush

3. Progress in Understanding the Mechanisms of Neuronal Dysfunction and Degeneration in Parkinson’s Disease
J. William Langston

4. a-Synuclein Aggregation and Parkinson’s Disease
Vladimir N. Uversky

5. Cell Biology of a-Synuclein: Implications in Parkinson’s Disease and Other Lewy Body Diseases
Seung-Jae Lee, Yoon Suk Kim

6. Pathogenesis of Prion Diseases
Giuseppe Legname, Stephen J. DeArmond, Fred E. Cohen, Stanley B. Prusiner

7. Mammalian Prion Protein
Ilia V. Baskakov

8. The Yeast Prion Proteins Sup35p and Ure2p
Joanna Krzewska, Ronald Melki

9. Immunoglobulin Light Chain and Systemic Light-Chain Amyloidosis
Marina Ramirez-Alvarado, Janelle K. Stigter, Elizabeth M. Baden, Laura A. Sikkink, Richard W. McLaughlin, Anya L. Taboas

10. Pancreatic Islet Amyloid and Diabetes
Anne Clark, Jenni Moffitt

11. ß2-Microglobulin and Dialysis-Related Amyloidosis
Isobel J. Morten, Eric W. Hewitt, Sheena E. Radford

12. Serum Amyloid A and AA Amyloidosis
Zafer Ali-Khan

II.Point Mutations and Enhanced Protein Deposition

13. Transthyretin and the Transthyretin Amyloidoses
Joel N. Buxbaum

14. Human Lysozyme
Mireille Dumoulin, Russell J. K. Johnson, Vittorio Bellotti, Christopher M. Dobson

15. Serpins and the Diversity of Conformational Diseases
Robin W. Carrell

III.Altered Protein Structure and Impaired Function

16. Human Copper-Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis
Ahmad Galaleldeen, P. John Hart

17. Understanding the Effects of Cancer-Associated Mutations in the Tumor Suppressor Protein p53: Structural Consequences of Mutations and Possible Ways of Rescuing Oncogenic Mutants
Andreas C. Joerger, Assaf Friedler, Alan R. Fersht

IV.Changes in Supramolecular Structure

18. Protein Aggregation in Muscle Fibers and Respective Neuromuscular Disorders
Alexandra Vrabie, Hans H. Goebel

19. Muscular Dystrophies and Protein Mutations
Mariz Vainzof, Mayana Zatz

20. The Functional Consequences of Dystrophin Deficiency in Skeletal Muscles
Jean-Marie Gillis

21. Eye Lens Proteins and Cataracts
Roger John Willis Truscott

V.Altered Protein Structure and Changes in Cellular/Nuclear Function

22. Glutamine/Asparagine-Rich Regions in Proteins and Polyglutamine Diseases
Hitoshi Okazawa

23. Mechanistic Insights into the Polyglutamine Ataxias
Victor M. Miller, Henry L. Paulson

24. Molecular Pathogenesis of the Polyglutamine Disease: Spinal and Bulbar Muscular Atrophy
Erica S. Chevalier-Larsen, Diane E. Merry

VI.Post-Translational Modification and Protein Conformational Diseases

25. Protein Glycation and Cataract: A Conformational Disease
John J. Harding

26. Defective Glycosylation and Muscular Dystrophies
Paul T. Martin

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Keywords: TECHNOLOGY & ENGINEERING / Biomedical TEC059000

Author(s)
 
Publisher
Springer
Publication year
2007
Language
en
Edition
1
Category
Medicine, Health Care, Mode
Format
Ebook
eISBN (PDF)
9780387365343

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