Misbehaving Proteins

Part I. Introduction

1. Protein Folding, Misfolding, Stability, and Aggregation
Regina M. Murphy, Amos M. Tsai

Part II. Mathematical Models and Computational Methods

2. Nonnative Protein Aggregation
Christopher J. Roberts

3. Simulations of Protein Aggregation
Carol K. Hall, Hung D. Nguyen, Alexander J. Marchut, Victoria Wagoner

Part III. Experimental Methods

4. Elucidating Structure, Stability, and Conformational Distributions during Protein Aggregation with Hydrogen Exchange and Mass Spectrometry
Erik J. Fernandez, Scott A. Tobler

5. Application of Spectroscopic and Calorimetric Techniques in Protein Formulation Development
Angela Wilcox, Rajesh Krishnamurthy

6. Small-Angle Neutron Scattering as a Probe for Protein Aggregation at Many Length Scales
Susan Krueger, Derek Ho, Amos Tsai

7. Laser Light Scattering as an Indispensable Tool for Probing Protein Aggregation
Regina M. Murphy, Christine C. Lee

8. X-ray Diffraction for Characterizing Structure in Protein Aggregates
Hideyo Inouye, Deepak Sharma, Daniel A. Kirschner

9. Glass Dynamics and the Preservation of Proteins
Christopher L. Soles, Amos M. Tsai, Marcus T. Cicerone

Part IV. Fundamental Studies in Model Systems

10. Folding and Misfolding as a Function of Polypeptide Chain Elongation
Silvia Cavagnero, Nese Kurt

11. Determinants of Protein Folding and Aggregation in P22 Tailspike Protein
Matthew J. Gage, Brian G. Lefebvre, Anne S. Robinson

12. Factors Affecting the Fibrillation of a-Synuclein, a Natively Unfolded Protein
Anthony L. Fink

13. Molten Globule-Lipid Bilayer Interactions and Their Implications for Protein Transport and Aggregation
Lisa A. Kueltzo, C. Russell Middaugh

Part V. Protein Product Development

14. Self-Association of Therapeutic Proteins
Mary E. M. Cromwell, Chantal Felten, Heather Flores, Jun Liu, Steven J. Shire

15. Mutational Approach to Improve Physical Stability of Protein Therapeutics Susceptible to Aggregation
Margaret Speed Ricci, Monica M. Pallitto, Linda Owers Narhi, Thomas Boone, David N. Brems

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Keywords: SCIENCE / Life Sciences / Biology / General SCI008000