Alzheimer’s Disease

1. The Genetics of Alzheimer’s Disease
Lars Bertram

2. APP Biology, Processing and Function
Gopal Thinakaran, Edward H. Koo

3. The Biology of the Presenilin Complexes
Tomoko Wakabayashi, Takeshi Iwatsubo, Bart Strooper

4. ß-secretase: Physiological Role and Target Validation
Fiona M. Laird, Mohamed H. Farah, Hey-Kyoung Lee, Alena V. Savonenko, Donald L. Price, Philip C. Wong

5. Cognitive Impairment in Transgenic Aß and Tau Models of Alzheimer’s Disease
Karen H. Ashe

6. Cholesterol and ß-Amyloid
Henri J. Huttunen, Dora M. Kovacs

7. Aß Structure and Aggregation
Charles Glabe, Ashley I. Bush

8. Signaling Mechanisms that Mediate Aß Induced Neuronal Dysfunction
Carl W. Cotman, Jorge Busciglio

9. Beta Amyloid and Excitatory Synapses
Roberto Malinow, Helen Hsieh, Wei Wei

10. Aß Degradation
Malcolm Leissring, Takaomi C. Saido

11. Role of A ß Transport and Clearance in the Pathogenesis and Treatment of Alzheimer’s Disease
David M. Holtzman, Berislav Zlokovic

12. Tau Gene Mutations in FTDP-17 Syndromes
Matthew J. Winton, John Q. Trojanowski, Virginia M -Y. Lee

13. Animal Models of Tauopathy
Karen Duff, Pavan Krishnamurthy, Emmanuel Planel, Michael Hutton

14. Tau and Axonal Transport
Eva-Maria Mandelkow, E. Thies, E. Mandelkow

15. Growth Factors in Alzheimer’s Disease
A. H. Nagahara, M. H. Tuszynski

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Keywords: TECHNOLOGY & ENGINEERING / Biomedical TEC059000