Dipeptidyl Aminopeptidases

Topic I.Structure and Function

1. Peptide Substrates of Dipeptidyl Peptidases
Inger Brandt, Anne-Marie Lambeir, Marie-Berthe Maes, Simon Scharpé, Ingrid Meester

2. Phosphorus-Containing Inhibitors of Proteolytic Enzymes
Angela Stöckel-Maschek, Beate Stiebitz, Bianca Senns, Nils Lindner, Werner Mögelin, Klaus Neubert

3. Biochemical Properties of Recombinant Prolyl Dipeptidases DPP-IV and DPP8
Xin Chen

4. Prediction of Dipeptidyl Peptidase (DP) 8 Structure by Homology Modelling
Melissa R. Pitman, R. Ian Menz, Catherine A. Abbott

Topic II.Dpiv-Related Enzymes

5. Structure and Function in Dipeptidyl Peptidase IV and Related Proteins
Mark D. Gorrell, Xin M. Wang, Joohong Park, Katerina Ajami, Denise Ming Tse Yu, Heather Knott, Devanshi Seth, Geoffrey W. McCaughan

6. Expression and Function of Dipeptidyl Peptidase IV and Related Enzymes in Cancer
Petr Busek, Evzen Krepela, Vladislav Mares, Kvetoslava Vlasicova, Jan Sevcik, Aleksi Sedo

7. DP8 and DP9 have Extra-Enzymatic Roles in Cell Adhesion, Migration and Apoptosis
Denise M. T. Yu, Xin M. Wang, Katerina Ajami, Geoffrey W. McCaughan, Mark D. Gorrell

8. In Vivo Effects of a Potent, Selective Dppii Inhibitor
Marie-Berthe Maes, Anne-Marie Lambeir, Pieter Veken, Benedicte Winter, Koen Augustyns, Simon Scharpé, Ingrid Meester

9. Expression of Dipeptidyl Peptidase IV-Like Enzymes in Human Peripheral Blood Mononuclear Cells
Sabine Wrenger, Bianca Guth, Bianca Schultze, Torsten Hoffmann, Daniel Friedrich, Thilo Kähne, Jürgen Faust, Klaus Neubert, Dirk Reinhold

10. Dipeptidyl Peptidase 8 Has Post-Proline Dipeptidyl Aminopeptidase and Prolyl Endopeptidase Activities
Joohong Park, Katerina Ajami, Denise M. T. Yu, Mark D. Gorrell

11. Prolyl Endopeptidase Cleaves the Apoptosis Rescue Peptide Humanin and Exhibits an Unknown Post-Cysteine Cleavage Specificity
Joachim Wolfgang Bär, Jens-Ulrich Rahfeld, Ingo Schulz, Kathrin Gans, David Ruiz-Carrillo, Susanne Manhart, Fred Rosche, Hans-Ulrich Demuth

12. Distribution of Dipeptidyl Peptidase Iv-Like Activity Enzymes in Canine and Porcine Tissue Sections by RT-PCR
Leona Wagner, Torsten Hoffmann, Jens-Ulrich Rahfeld, Hans-Ulrich Demuth

Topic III.Metabolic Disorders

13. Relative Contribution of Incretins to the Glucose Lowering Effect of DP IV Inhibitors in Type 2 Diabetes Mellitus (T2DM)
Simon A. Hinke, Raymond A. Pederson, Christopher H. S. McIntosh

14. Dipeptidyl Peptidase IV: A Molecular Switch of Vascular Actions of Neuropeptide Y
Lijun Li, Hans-Ulrich Demuth, Zofia Zukowska

Topic IV.Immune Disorders

15. Dipeptidylpeptidase IV (DPIV) and Alanyl-Aminopeptidases (AAPs) as a New Target Complex for Treatment of Autoimmune and Inflammatory Diseases—Proof of Concept in a Mouse Model of Colitis
Ute Bank, Janine Tadje, Martin Helmuth, Sofia Stefin, Michael Täger, Carmen Wolke, Anke Wischeropp, Annelore Ittenson, Dirk Reinhold, Siegfried Ansorge, Uwe Lendeckel

16. Dipeptidyl Peptidases and Inflammatory Bowel Disease
Catherine A Abbott, Roger Yazbeck, Mark S Geier, Hans-Ulrich Demuth, Gordon S Howarth

17. Possible Role of DP IV Inhibitors in Acne Therapy
Anja Thielitz, Dirk Reinhold, Robert Vetter, Uwe Lendeckel, Thilo Kähne, Ute Bank, Martin Helmuth, Klaus Neubert, Jürgen Faust, Roland Hartig, Sabine Wrenger, Christos C. Zouboulis, Siegfried Ansorge, Harald Gollnick

18. Dipeptidyl Peptidase-IV Activity and/or Structure Homologs (DASH): Contributing Factors in the Pathogenesis of Rheumatic Diseases?
Eva Balaziova, Liliana Sedova, Vladislav Mares, Kvetoslava Vlasicova, Jan Sevcik, Aleksi Sedo

Topic V.Neuronal Diseases

19. Dipeptidyl Peptidase IV (DP IV, CD26) and Aminopeptidase N (APN, CD13) as Regulators of T Cell Function and Targets of Immunotherapy in CNS Inflammation
Aliza Biton, Ute Bank, Michael Täger, Siegfried Ansorge, Dirk Reinhold, Uwe Lendeckel, Stefan Brocke

20. CD26/DP IV in T Cell Activation and Autoimmunity
Vera Preller, Annegret Gerber, Mauro Togni, Sabine Wrenger, Burkhart Schraven, Christoph Röcken, Didier Marguet, Siegfried Ansorge, Stefan Brocke, Dirk Reinhold

Topic VI.Cancer

21. DPIV/CD26 and FAP in Cancer: A Tale of Contradictions
Melanie L Sulda, Catherine A Abbott, Martin Hildebrandt

22. Type-II Transmembrane Prolyl Dipeptidases and Matrix Metalloproteinases in Membrane Vesicles of Active Endothelial Cells
Monica Salamone, Mirko Siragusa, Mario Nasca, Laura Pitarresi, Maria L. Vittorelli, Wen-Tien Chen, Guilio Ghersi

23. Extra-Enzymatic Roles of DPIV and FAP in Cell Adhesion and Migration on Collagen and Fibronectin
Xin M. Wang, Denise M. T. Yu, Geoffrey W. McCaughan, Mark D. Gorrell

24. Role of Neuropeptide Y and Dipeptidyl Peptidase IV in Regulation of Ewing’s Sarcoma Growth
Joanna Kitlinska, Lydia Kuo, Ken Abe, Jennifer Pons, Muchieh Yu, Lijun Li, Jason Tilan, Jeffrey Toretsky, Zofia Zukowska

25. The Role of CD26/DPP IV in Preservation of Early Pulmonary Graft Function
Florian Johannes Jung, Markus Cardell, Lin Yang, Ingrid Meester, Koen Augustyns, Sven Hillinger, Simon Scharpe, Walter Weder, Stephan Korom

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Keywords: TECHNOLOGY & ENGINEERING / Biomedical TEC059000