Keller, Jeffrey N.

The Proteasome in Neurodegeneration

Keller, Jeffrey N. - The Proteasome in Neurodegeneration, ebook


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ISBN: 9780387285009
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Table of contents

Part I.Basic Aspects of Protein Degradation Through the Ubiquitin Proteasome System (UPS)

1. Yeast Proteasome Structure and Biogenesis
Cordula Enenkel

2. Ubiquitin-Proteasome System in the Central Nervous System
Qunxing Ding, Jeffrey N. Keller

Part II.Protein Aggregation, Inclusion Formation and Ups Function

3. Protein Aggregation and the UPS: A Two-Way Street
Kostas Vekrellis, Leonidas Stefanis

4. The Impact of Inclusion Formation on Cell Survival
M. Maral Mouradian, Mikiei Tanaka, Gwang Lee, Eunsung Junn

5. Inclusion Formation and Disolution Following Proteasomal Inhibition in Neuronal Cells
Leonidas Stefanis, Hardy J. Rideout

Part III.Oxidative Stress and Ups Function

6. The Proteasome: Source and a Target of Oxidative Stress?
Barry Halliwell

7. Inflammation as a Mediator of Oxidative Stress and UPS Dysfunction
Thomas Schmidt-Glenewinkel, Maria Figueiredo-Pereira

Part IV.Proteasome and Neuronal Cell Death and Survival

8. Role of the Ubiquitin Proteasome System During Neuronal Cell Death
Nadia Canu, Pietro Calissano

9. Pathways of Neuronal Cell Death Induced by Proteasomal Inhibition
Isabelle Lang-Rollin, Leonidas Stefanis

Part V.Models of Dysfunction of the UPS and the Proteasome

10. Pharmacological and Molecular Models of Proteasomal Dysfunction
Thomas Schmidt-Glenewinkel, Maria Figuierdo-Pereira

11. The Gad Mouse: A Window Into UPS-Related Neurodegeneration and the Function of the Function of the Deubiquitinating Enzyme Uch-L1
Jungkee Kwon, Keiji Wada

Part VI.The UPS in Neurodegenerative Diseases and Aging

12. Parkinson’s Disease and Related Disorders
Mark Cookson

13. Ubiquitination by Parkin — Implications in Parkinson’s Disease
Sathya Ravichandran, Ted M. Dawson, Valina L. Dawson

14. The Ups in Neurodegenerative Diseases and Aging Huntington’s Disease
M. Diaz-Hernandez, J. J. Lucas

15. Frameshift Mutant Ubiquitin in Alzheimer’s Disease and Other Neurodegenerative Disorders
Robert Layfield

16. Motor Neuron Disease
Heather D. Durham, Edor Kabashi, David M. Taylor, Jeffrey N. Agar

17. The Paradoxical Role of Proteasomes in Prion Disorders
Neena Singh, Yaping Gu, Sharmila Bose, Subhabrata Basu, Xiu Luo, Ajitesh Ojha, Richa Mishra

18. Aging and the Proteasome
Qunxing Ding, Jeffrey N. Keller


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Keywords: TECHNOLOGY & ENGINEERING / Biomedical TEC059000

Publication year
Medicine, Health Care, Mode

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