Post-Genomic Perspectives in Modeling and Control of Breathing

1. Views on the Human Breathing Behavior

1. Different Profile in Ventilatory vs. Respiratory Sensation Responses to CO2 with Varying Po2

Atsuko Masuda, Yoshikazu Sakakibara, Toshio Kobayashi, Michiko Tanaka, Yoshiyuki Honda

2. Amygdala and Emotional Breathing in Humans
Yuri Masaoka, Ikuo Homma

3. Immediate Effects of Bilateral Carotid Body Resection on Total Respiratory Resistance and Compliance in Humans
Benjamin Winter, Brian J. Whipp

4. Memories of Yoshiyuki Honda, MD, PhD
John W. Severinghaus

5. Memories of Dr. Yoshiyuki Honda
Yoshikazu Sakakibara

2. Mechanisms of Central and Carotid Bodies Chemoreception

6. Chemosensory Control of the Respiratory Function
Alexander V. Gourine, Nicholas Dale, K. Michael Spyer

7. Brainstem NHE-3 Expression and Control of Breathing
Martin Wiemann, Heidrun Kiwull-Schöne, Stilla Frede, Dieter Bingmann, Peter Kiwull

8. Functional Connection From the Surface Chemosensitive Region to the Respiratory Neuronal Network in the Rat Medulla
Yasumasa Okada, Zibin Chen, Wuhan Jiang, Shun-ichi Kuwana, Frederic L. Eldridge

9. Chemosensory Inputs and Neural Remodeling in Carotid Body and Brainstem Catecholaminergic Cells
Christophe Soulage, Olivier Pascual, Jean-Christophe Roux, Monique Denavit-Saubié, Jean-Marc Pequignot

10. Role of Fe2+ in Oxygen Sensing in the Carotid Body
S. Lahiri, A. Roy, J. Li, S. M. Baby, A. Mokashi, C. Giulio

11. Ventilatory Responsiveness to CO2 Above & Below Eupnea: Relative Importance of Peripheral Chemoreception
Curtis A. Smith, Bruno J. Chenuel, Hideaki Nakayama, Jerome A. Dempsey

12. Carotid Body Tumors in Humans Caused by a Mutation in the Gene for Succinate Dehydrogenase D (SDHD)
Albert Dahan, Peter E. M. Taschner, Jeroen C. Jansen, Andel Mey, Luc J. Teppema, Cees J. Cornelisse

13. A SIDS-Like Phenotype is Associated With Reduced Respiratory Chemoresponses in PACAP Deficient Neonatal Mice
Kevin J. Cummings, Jonathan D. Pendlebury, Frank R. Jirik, Nancy M. Sherwood, Richard J. A. Wlison

14. Selective Alteration of the Ventilatory Response to Hypoxia Results from Mutation in the Myelin Proteolipid Protein Gene
Martha J. Miller, Musa A. Haxhiu, Cindy D. Kangas, Paraskevi Georgiadis, Tatyana I. Gudz, Wendy B. Macklin

3. From Neurons to Neural Assemblies: Brainstem Control of Rhythm Generation

15. Organization of Central Pathways Mediating the Hering-Breuer Reflex and Carotid Chemoreflex
Chi-Sang Poon

16. Converging Functional and Anatomical Evidence for Novel Brainstem Respiratory Compartments in the Rat
Donald R. McCrimmon, George F. Alheid, Minchun Jiang, Tara Calandriello, Anupama Topgi

17. Eupneic Respiratory Rhythm in Awake Goats is Dependent on an Intact Pre-Bötzinger Complex
H. V. Forster, J. M. Wenninger, L. G. Pan, M. R. Hodges, R. Banzett

18. BDNF Preferentially Targets Membrane Properties of Rhythmically Active Neurons in the pre-Bötzinger Complex in Neonatal Mice
Muriel Thoby-Brisson, Sandra Autran, Gilles Fortin, Jean Champagnat

19. Ionic Currents and Endogenous Rhythm Generation in the pre-Bötzinger Complex: Modelling and In Vitro Studies
Ilya A. Rybak, Natalia A. Shevtsova, Walter M. St. John, Julian F. R. Paton, Olivier Pierrefiche

20. Modulation of Inspiratory Inhibition of the Bötzinger Complex by Raphe Pallidus and Locus Coeruleus in Rabbits
Guimin Wang, Shuyan Yu, Fayan Zhang, Yanchun Li, Ying Cao, Qin Li, Gang Song, Heng Zhang

21. Behavioural Control of Breathing in Mammals: Role of the Midbrain Periaqueductal Gray
Harl H. Subramanian, Ron J. Balnave, Chin Moi Chow

22. Breathing at Birth: Influence of Early Developmental Events
Gilles Fortin, Caroline Borday, Isabelle Germon, Jean Champagnat

4. From Molecular to Integrated Neural Control of Breathing

23. A Dual-Role Played by Extracellular ATP in Frequency-Filtering of the Nucleus Tractus Solltarii Network
Fusao Kato, Eiji Shigetomi, Koji Yamazaki, Noriko Tsuji, Kazuo Takano

24. Role of GABA in Central Respiratory Control Studied in Mice Lacking GABA-Synthesizing Enzyme 67-kDa Isoform of Glutamic Acid Decarboxylase
Shun-ichi Kuwana, Yasumasa Okada, Yoshiko Sugawara, Kunlhlko Obata

25. Breathing Without Acetylcholinesterase
Fabrice Chatonnet, Eliane Boudinot, Arnaud Chatonnet, Jean Champagnat, Arthur S. Foutz

26. In-Silico Model of NMDA and Non-NMDA Receptor Activities Using Analog Very-Large-Scale Integrated Circuits
Guy Rachmuth, Chi-Sang Poon

27. Respiratory Role of Ionotropic Glutamate Receptors in the Rostral Ventral Respiratory Group of the Rabbit
Donatella Mutolo, Fulvia Bongianni, Tito Pantaleo

28. Serotonergic Receptors and Effects in Hypoglossal and Laryngeal Motoneurons
Denys V. Volgin, Victor B. Fenik, Richard Fay, Shlnlchi Okabe, Richard O. Davies, Leszek Kubin

29. Modelling Respiratory Rhythmogenesis: Focus on Phase Switching Mechanisms
Ilya A. Rybak, Natalia A. Shevtsova, Julian F. R. Paton, Olivier Pierrefiche, Walter M. St.-John, Akira Haji

5. Respiratory Activity During Sleep and Anesthesia

30. Ventilatory Instability Induced by Selective Carotid Body Inhibition in the Sleeping Dog
B. J. Chenuel, C. A. Smith, K. S. Henderson, J. A. Dempsey

31. Stability Analysis of the Respiratory Control System During Sleep
Zbignlew L. Topor, Konstantinon Vasilakos, John E. Remmers

32. A Physical Model of Inspiratory Flow Limitation in Awake Healthy Subjects
Abdelkebir Sabil, André Eberhard, Pierre Baconnier, Gila Benchetrit

33. Antioxidants Prevent Blunting of Hypoxic Ventilatory Response by Low-Dose Halothane
Albert Dahan, Raymonda Romberg, Elise Sarton, Luc Teppema

34. Mechanism of Propofol-Induced Central Respiratory Depression in Neonatal Rats
Masanori Kashiwagi, Yasumasa Okada, Shun-ichi Kuwana, Shigeki Sakuraba, Ryoichi Ochiai, Junzo Takeda

35. Interaction of Arousal States with Depression of Acute Hypoxic Ventilatory Response by 0.1 MAC Halothane
Jaideep J. Pandit, Ben Moreau, Peter A. Robbins

6. Cardio-Respiratory Regulations and Cerebral Blood Flow

36. Relationship Between Ventilatory and Circulatory Responses to Sustained Mild Hypoxia in Humans
Toshio Kobayashi, Atsuko Masuda, Yoshikazu Sakakibara, Michiko Tanaka, Shigeru Masuyama, Yoshiyukl Honda

37. Respiratory, Cerebrovascular and Pressor Responses to Acute Hypoxia: Dependency on Pet
Co
2

Philip N. Ainslie, Marc J. Poulin

38. Can Cardiogenic Oscillations Provide an Estimate of Chest Wall Mechanics?
Eve Bijaoui, Daniel Anglade, Pascale Calabrese, André Eberhard, Pierre Baconnier, Gila Benchetrit

39. Nonlinear Modeling of the Dynamic Effects of Arterial Pressure and Blood Gas Variations on Cerebral Blood Flow in Healthy Humans
Georgios D. Mitsis, Philip N. Ainslie, Marc J. Poulin, Peter A. Robbins, Vasilis Z. Marmarelis

7. Ventilatory Response to Exercise

40. Mixed Venous CO2 and Ventilation During Exercise and CO2-Rebreathing in Humans
Toru Satoh, Yasumasa Okada, Yasushi Hara, Fumio Sakamaki, Shingo Kyotani, Takeshi Tomita

41. Effects of Pain and Audiovisual Stimulation on the Hypoxic Ventllatory Response
Suzanne B. Karan, J. Russell Norton, William Voter, Linda Palmer, Denham S. Ward

42. Effect of Progressive Hypoxia with Moderate Hypercapnia on Ventilatory vs. Respiratory Sensation Responses in Humans
Yoshikazu Sakakibara, Atsuko Masuda, Toshio Kobayashi, Shigeru Masuyama, Yoshiyuki Honda

43. Frequency Response of the Input Reaching the Respiratory Centres During Moderate Intensity Exercise
Philippe Haouzi, Bruno Chenuel, Bernard Chalon

8. Variability and Plasticity of Breathing

44. Effects of Resistive Loading on Breathing Variability
S. Thibault, P. Calabrese, G. Benchetrit, P. Baconnier

45. Effects of Intermittent Hypoxic Training and Detraining on Ventilatory Chemosensitive Adaptations in Endurance Athletes
Keisho Katayama, Kohei Sato, Hiroshi Matsuo, Koji Ishida, Shigeo Mori, Mlharu Miyamura

46. Effects of 5 Consecutive Nocturnal Hypoxic Exposures on Respiratory Control and Hematogenesis in Humans
Jon C. Kolb, Philip N. Ainslie, Kojiro Ide, Marc J. Poulin

47. Memory, Reconsolidation and Extinction in Lymnaea Require the Soma of RPeD1
Susan Sangha, Nishi Varshney, Mary Fras, Kim Smyth, David Rosenegger, Kashif Parvez, Hisayo Sadamoto, Ken Lukowiak

9. Conclusions and Perspectives

48. Modeling and Control of Breathing: Perspectives from Pre- to Post-Genomic Era
Chi-Sang Poon

49. Post-Genomic Perspectives in Modeling and Control of Breathing
Jean Champagnat

Keywords: Biomedicine, Neurosciences, Pathology