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Blondelle, Sylvie E.

Understanding Biology Using Peptides

Blondelle, Sylvie E. - Understanding Biology Using Peptides, ebook

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ISBN: 9780387265759
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Table of contents

1. From Tens to Trillions - Advances in Synthetic Combinatorial Chemistry of Peptides, Peptidomimetics and Heterocyclic Compounds Derived from Peptides
Richard A. Houghten

2. Peptides in the Days of Photonics
Christian Renner, Luis Moroder

3. It All Started in Brooklyn, NY, Forty-five Years Ago!
Claudio Toniolo

4. Short Transmembrane Peptide Sequences as Nucleation Sites for Globular Protein Folding
Arianna Rath, Linda Lee, Rachel M. Johnson, Charles M. Deber

5. Synthesis and In Vitro Opioid Activity Profiles of Novel Cyclic Enkephalin Analogs
Peter W. Schiller, Grazyna Weltrowska, Irena Berezowska, Carole Lemieux, Nga N. Chung, Brian C. Wilkes

6. A Photo-Controlled ß-Hairpin
Markus Löweneck, Shou-Liang Dong, Tobias E. Schrader, Wolfgang J. Schreier, Wolfgang Zinth, Luis Moroder, Christian Renner

7. Structure-Function Relationship Studies of Analogs of PTH(1–11) Fragment Containing Combinations of Aib and (aMe)Nle
Andrea Caporale, Nereo Fiori, Elisabetta Schievano, Michael Chorev, Stefano Mammi, Evaristo Peggion

8. Membrane Associated Structure of a Ghrelin Agonist as Determined by NMR
Dale F. Mierke, Andrea Piserchio, John Eynon, Jundong Zhang, John E. Taylor, Heather Halem, Michael D. Culler, Jesse Z. Dong

9. Scaffold, Dendritic and Metal-Assisted Assembly of Collagen-Like Biomaterials
Weibo Cai, Sen Wai Kwok, Joseph P. Taulane, Murray Goodman

10. Positional Scanning for Peptide Secondary Structure by Solid Phase Synthesis with Aza-Amino Acids and Freidinger Lactams
Damien R. Boeglin, Mandar S. Bodas, Fabrice Galaud, William D. Lubell

11. Synthesis of Cyclic Peptides via Transition Metal Catalyzed C-C Bond Formation
Dirk T. S. Rijkers, Hefziba T. Brink, Nourdin Ghalit, Jan Tois, Rob M. J. Liskamp

12. Solid Phase Synthesis of Phosphorylated Cis and Trans 3-Peptidyl-4-(4'-hydroxyphenyl)-ß-Lactams
David R. Coleman, Kumar K. Kaluarachchi, John S. McMurray

13. Switch on Amyloid ß Peptide Self-Assembly by Enzyme-Triggered Acyl Migration
Sonia Santos, Arunan Chandravarkar, Bhubaneswar Mandal, Richard Mimna, Karine Murat, Lydiane Saucède, Marie-Stephanie Camus, Gabriele Tuchscherer, Manfred Mutter

14. ROMP of Norbornyl Oligopeptides: A Versatile Synthetic Method for Exploring Receptor Topology
Younjoo Lee, Keith Baessler, Nicole S. Sampson

15. Native Chemical Ligation at Aromatic Residues
Sylvie Tchertchian, Fred Opligger, Marianne Paolini, Sonia Manganiello, Sylvain Raimondi, Benoît Depresle, Nicolas Dafflon, Hubert Gaertner, Paolo Botti

16. Robotic Synthesis of Soluble Peptide Arrays
Wen Lin, James G. Boyd

17. Covalent Capture: Application to Peptides Possessing Auxiliary Groups for Extended Chemical Ligation
Nikolett Mihala, Keith Rose

18. Asymmetric Induction on a Racemic Amine by Chiral Dipeptide 5(4H)-Oxazolones from Ca-Methyl Phenylglycine
Alessandro Moretto, Cristina Peggion, Fernando Formaggio, Marco Crisma, Bernard Kaptein, Quirinus B. Broxterman, Claudio Toniolo

19. Poly(ethylene glycol) (PEG) Modifications and Conformational Analysis of Thymosin a 1
Keliang Liu, Jiankun Qie, Jinbo Ma, Liangyou Wang, Wenxia Zhou, Chunhui Qi, Xiunan Zhao, Jianquan Zheng, Sijian Dong

20. Suppression of Side Reactions Associated with Use of the Benzyloxymethyl Group on Histidine
Kumiko Yoshizawa-Kumagaye, Takehiro Ishizu, Shuji Isaka, Masaji Tamura, Rumi Okihara, Yuji Nishiuchi, Terutoshi Kimura

21. Peptide Synthesis in Water: 2-(4-Sulfophenylsulfonyl)ethoxycarbonyl Group and Coupling Reagents
Keiko Hojo, Mitsuko Maeda, Koichi Kawasaki

22. Efficient Synthesis in Solid-Phase of Freidinger-like Lactams by Microwave Irradiation
Teresa Lama, Pietro Campiglia, Luigia Auriemma, Isabel Gomez-Monterrey, Alfonso Carotenuto, Ettore Novellino, Paolo Grieco

23. Synthesis of Monocyte Chemoattractant Protein 1 (MCP-1) Analogs via Native Chemical Ligation
Tami L. Raguse, Nicole Stowell, Reannon Holland, Thomas Bodenstine, Steven C. Pomerantz, Jennifer F. Nemeth, Anuk Das, Marian Kruszynski, George A. Heavner

24. NMR Analysis of a Multi-domain Peptide of the Saccharomyces cerevisiae Alpha Factor Receptor
Racha Estephan, Jacqueline Englander, Boris Arshava, Jeffrey M. Becker, Fred Naider

25. Further Studies on an Alternative Approach to Prepare Esterified Protected Peptides under Mild Conditions
Patrícia B. Proti, Pedro V. Oliveira, M. Terêsa M. Miranda

26. A Long Range S,N-Acyl Migration by Silver Ion Assistance in Thioester Ligation
Yi-An Lu, James P. Tam

27. The C-Terminal Fragment of Acanthoscurrin is a Difficult Sequence
César Remuzgo, Gustavo F. S. Andrade, Maria L. A. Temperini, Sirlei Daffre, M. Terêsa M. Miranda

28. A Novel Approach to Resin-based Cysteine Alkylation
Bin Yang, Richard D. DiMarchi

29. Deprotection of the p-Methoxybenzyl Group of Selenocysteine by Neighboring Group Participation
Katharine M. Harris, Robert J. Hondal

30. Overcoming Challenges in Automated Long Peptide Synthesis — A Multi-pronged Approach
Yingwei He, Guodi Lu, John Mountzouris, Chun Wu

31. Synthesis and Biological Evaluation of Antagonist Analogs of the Peptide Hormone Oxytocin
Jake L. Stymiest, Bryan F. Mitchell, Susan Wong, John C. Vederas

32. Development of Wang Resin Supported Evans-type Oxazolidinone for Asymmetric Reaction
Tomoya Kotake, Yoshio Hayashi, S. Rajesh, Tooru Kimura, Yoshiaki Kiso

33. A Convenient Synthetic Method for Monodehydro-2,5-diketopiperazines
Yoshio Hayashi, Akiko Oda, Yuri Yamazaki, Yuka Okuno, Yoshiaki Kiso

34. Solid-Phase Synthesis of Azole-Based Peptides and Peptidomimetics
Eric Biron, Horst Kessler

35. Efficient Synthesis of N-Methylamino Acids Compatible with Fmoc Solid-Phase Peptide Synthesis
Eric Biron, Jayanta Chatterjee, Horst Kessler

36. The “O-Acyl Isopeptide Method” for the Synthesis of Alzheimer’s Disease-Related Amyloid ß Peptide (Aß) 1–42
Youhei Sohma, Maiko Kimura, Yousuke Chiyomori, Yoshio Hayashi, Atsuhiko Taniguchi, Masato Sasaki, Tooru Kimura, Yoshiaki Kiso

37. The “O-Acyl Isopeptide Method” for the Synthesis of Difficult Sequence-Containing Peptides: Application to the Synthesis of Alzheimer’s Disease-Related Amyloid ß Peptide (Aß) 1–42 Mutants
Yousuke Chiyomori, Youhei Sohma, Maiko Kimura, Yoshio Hayashi, Fukue Fukao, Atsuhiko Taniguchi, Tooru Kimura, Yoshiaki Kiso

38. Enhancing Atom Economy of SPS: Recoverable and Reusable Building Blocks for Depsipeptide Synthesis
Jan Spengler, Javier Ruíz-Rodríguez, Tommaso Cupido, Klaus Burger, Fernando Albericio

39. 1-N-Methyl-Histidine as a Side-Product in Backbone N-Methylated PTH Analogs
Zhanna Potetinova, Gordon E. Willick

40. Combinatorial Approach in the Synthesis of a Small Library of ß-Turn Structures Based on Thiazolidine Moiety
Alfonso Carotenuto, Teresa Lama, Orazio Mazzoni, Pietro Campiglia, Ettore Novellino, Alessia Bertamino, Maria V. Diurno, Isabel Gomez-Monterrey, Luigia Auriemma, Paolo Grieco

41. Solid-Phase Peptide Synthesis Using ChemMatrix®, a Polyethylenglycol (PEG)-based Solid
Fernando Albericio, Nuria Bayo, Silvia A. Camperi, Osvaldo Cascone, Simon Côté, Luis J. Cruz, Abdelhamid Errachid, Robert Furic, Fayna García-Martín, Yesica García-Ramos, Nancy B. Iannucci, Mariela M. Marani, Mateu Pla-Roca, Martina Quintanar-Audelo, Josep Samitier, Judit Tulla-Puche

42. p-Nitrobenzyloxycarbonyl (pNZ) as an Alternative to Fmoc for the Protection of Amines in Solid-Phase Peptide Synthesis
Albert Isidro-Llobet, Pilar E. López, Judit Guasch-Camell, Mercedes álvarez, Fernando Albericio

43. Synthesis and NMR Analysis of CCR5 and CXCR4 Peptides Containing Tyrosine Sulfate
Tatsuya Inui, Patricia Cano-Sanchez, Boris Arshava, Inbal Ayzenshtat, Jacob Anglister, Fred Naider

44. Steroid-Peptide Conjugates
Witold A. Neugebauer, Jérôme Côté, Audrey Fortier, Ghassan Bkaily, Levon Avedanian, Danielle Jaques, Fernand Gobeil

45. Influence of Natural Loop Residues or Oligolysines on the Biophysical Properties of Transmembrane Domains of a G Protein-Coupled Receptor
Patricia Cano-Sanchez, Tatsuya Inui, Beatrice Severino, V. V. Suresh Babu, Boris Arshava, Jeffrey M. Becker, Fred Naider

46. Design, Synthesis and Analysis of Constrained B-Cell Epitope from HER-2 Protein
Sharad V. Rawale, Pravin T. P. Kaumaya

47. Synthesis of the Four Stereoisomers of N-Fmoc-O-t-Bu-4,4,4- trifluorothreonine
Zhong-Xing Jiang, Yihua Bruce Yu

48. Synthesis of N a-Fmoc-N e-[(2-nitrophenyl)acetyl]-lysine (Fmoc-Lys(Npa)-OH) and its Applications in Solid-Phase Peptide Synthesis
Aimin Song, Lucy Wu, Xiaobing Wang, Kit S. Lam

49. A MS-based Encoding Method for OBOC Combinatorial Branched Peptide Libraries
Xiaobing Wang, Kit S. Lam

50. Sequential Chemical Ligation for Polypeptide Synthesis by the Combination of the Thioester Method and the Extended Chemical Ligation Using a Photoremovable Auxiliary
Toru Kawakami, Masahiro Tsuchiya, Ken’ichiroh Nakamura, Saburo Aimoto

51. Solid-Phase Synthesis of a Mucin Glycopeptide Segment from CD43 for NMR and Crystallization Studies
Mian Liu, George Barany, David Live

52. SPPS of Bacterial Addressed Peptides and PNAs Overcoming the Resistance against Antibiotics
Rüdiger Pipkorn, Waldemar Waldeck, Klaus Braun

53. Convergent Synthesis of the Cysteine-rich Mdm2 RING Finger Domain
Zoe Vasileiou, Dimitrios Gatos, Kleomenis Barlos

54. Evaluation of Polyamide-Polystyrene Block Polymers in Peptide Synthesis and Biochemistry
Spyros Markos, Antonios Saravanos, Michael Batistatos, Alexios Aletras, Dimitrios Gatos, Kleomenis Barlos

55. New Nomenclature for Complex Cyclopeptides
Jan Spengler, José-Carlos Jiménez, Klaus Burger, Ernest Giralt, Fernando Albericio

56. New Approaches for Native Chemical Ligation
Dana Baas, Daniel G. Mullen, George Barany

57. Microwave-Assisted Solid-Phase Peptide Synthesis (MW-SPPS) on CLEAR Supports
Anne L. Carenbauer, Matthew R. Cecil, Andrzej Czerwinski, Krzysztof Darlak, Miroslawa Darlak, DeAnna Wiegandt Long, Francisco Valenzuela, George Barany

58. Microwave Assisted Peptide Synthesis — A Tool to Replace Classical SPPS?
Andreas Rybka, Hans-Georg Frank

59. Fast and Versatile Peptide Backbone Modifications Using Microwave Energy
Daniel Raichman, Gerardo Byk

60. Microwave-Assisted Synthesis of Multivalent Dendrimeric Peptides using Cycloaddition Reaction (‘Click’) Chemistry
Dirk T. S. Rijkers, G. Wilma Esse, Remco Merkx, Arwin J. Brouwer, Hans J. F. Jacobs, Roland J. Pieters, Rob M. J. Liskamp

61. Efficient Synthesis of Disulfide Bridge Containing Peptides: Melanin Concentrating Hormone (MCH) and Brain Natriuretic Peptide (BNP)
Jianjun Jiang, Brian D. Dayton, Sevan J. Brodjian, Bryan C. Tieman, Susan E. Brophy, Paul L. Richardson

62. Rapid Solution-phase Synthesis of a 20-mer Peptide According to the DioRaSSP® Method
Ivo F. Eggen, Frits T. Bakelaar, Paul B. W. Kortenaar, Knut Adermann, Wolf-Georg Forssmann, Axel Schulz

63. A New Efficient Post-Assembly Strategy for the Synthesis of Sulfated Peptides
John A. W. Kruijtzer, Johan Kemmink, Rob M. J. Liskamp

64. Auxiliary Group-Assisted Peptide Thioester Preparation Based on On-resin N-S Acyl Shift Triggered by TFA Treatment
Megumi Sumida, Ken’ichiroh Nakamura, Toru Kawakami, Thomas Vorherr, Saburo Aimoto

65. Determination of an Optimal Solid Support for Use with Microwave-Assisted Solid-Phase Peptide Synthesis
Sandra C. Vigil-Cruz, Angela M. Peck, Jane V. Aldrich

66. Efficient Recombinant Production of the 16 Amino Acid Peptide AOD9604
Allan W. Hey, Angelo Guidolin, Reza Zareie, Kathryn Smith, Ela Knapik, Stan Bastiras

67. Chemical Synthesis of the Gsti Protein by a NCL Method on a X-Met Site
Daniela Marasco, Angela Saporito, Paolo Botti, Eduardo Patriarca, Rossella Fasulo, Alessandro Spasiano, Carlo Pedone, Ettore Benedetti, Menotti Ruvo

68. N,O-Acyl Shifts: Unexpected Side-Reaction and Beneficial Tool in Fmoc-Chemistry
Louis A. Carpino, Calin D. Sferdean, Irene Coin, Sandra Tremmel, Eberhard Krause, Michael Bienert, Michael Beyermann

69. Magnetic CLEAR Beads for Solid-Phase Synthesis of Peptides and Affinity Ligands
Pottayil G. Sasikumar, Maria Kempe

70. An Efficient and Facile Synthesis of Tyrosine-Sulfate-Containing Peptides: Synthesis of the N-Terminal Peptide of CCR5 and Its Analog
Hasmik Sargsyan, Boris Arshava, Patricia Cano, Tatsuya Inui, Jacob Anglister, Fred Naider

71. Interaction of DPH with the Local Anesthetic Receptor Site in D1-S6 of the Na+ Channel by NMR and Molecular Modeling
Bih-Show Lou, Ta-Hsien Lin

72. The Structural Determinants of GPCR Binding and Activation: Insights from Mutagenesis and Molecular Modeling Studies of the Human Angiotensin II Type 1 (hAT1) Receptor
Marie-Eve Beaulieu, Pierre Lavigne, Emanuel Escher

73. Protein Epitope Mimetics A New Approach to Target Protein-Protein Interactions
Frank Otto Gombert, Jan Willem Vrijbloed, Daniel Obrecht

74. Application of Phenylphosphate Mimetics to the Design and Synthesis of Olefin Metathesis-Derived Grb2 SH2 Domain-Binding Macrocycles
Sang-Uk Kang, Zhen-Dan Shi1, Rajeshri Kariki1, Jason Phan, Karen M. Worthy, Lakshman K. Bindu, Marc Nicklaus, David S. Waugh, Robert J. Fisher, Terrence R. Burke

75. Radiolabeled Peptides as CXCR4 Ligands
Ettore Benedetti, Giancarlo Morelli, Raffaella Moglie, Stefania Luca, Luigi Aloj, Andrea Ciarmiello, Secondo Lastoria, Claudio Arra, Amelia D’Alessio, Laura Tarallo

76. Aza-peptides with Multiple Aza-amino Acids, Synthesis and Preliminary Conformational Analysis of Glu-azaAla-Ala-azaAla-Leu-azaAla-Lys-azaAla-NH2
Damien R. Boeglin, Mallem H. V. Ramana Rao, Jean-Philippe Demers, William D. Lubell

77. Design and Synthesis of Bicyclic Internal ß-Turn Mimetics and their Applications toward Biologically Interesting Ligands
Byoung J. Min, Xuyuan Gu, Ravil R. Petrov, Yeon Sun Lee, Victor J. Hruby

78. Synthesis and Incorporation of Freidinger Lactam Analogs in GHRP-6
Fabrice Galaud, Annie Demers, Huy Ong, William D. Lubell

79. Microwave-assisted Synthesis of N-glycosylated Building Blocks
Ilaria Paolini, Francesca Nuti, Giuseppina Sabatino, Mario Chelli, Anna M. Papini

80. Parallel Solid-Phase Synthesis of Mucin-Like Glycopeptides from an a-GalN3 O-Linked Threonine Building Block
Mian Liu, David Live, George Barany

81. Synthesis of Silyl Ether Linkers for Solid-Phase Peptide Synthesis
Cassidy M. Dobson, George Barany, Rita S. Majerle

82. Synthetic Routes to, and Mechanistic Understanding of, Dithiasuccinoyl (Dts)-Amines and Chlorocarbonyl Carbamoyl Disulfanes
Michael J. Barany, Megan M. Corey, Michael C. Hanson, Rita S. Majerle, Robert P. Hammer, George Barany

83. Peptide-Derived (Sulfonyl)Azides as Versatile Synthons in Chemoselective Bioconjugations
Remco Merkx, Dirk T. S. Rijkers, Arwin J. Brouwer, Johan Kemmink, Rob M. J. Liskamp

84. Chemically Synthesized Annexin-A5-Based Probes for Molecular Imaging
Cheng-Bin Yim, Anouk Dirksen, Chris P. M. Reutelingsperger, Tilman M. Hackeng

85. Unequivocal Synthesis of (Z)-Alkene or (E)-Fluoroalkene Dipeptide Isosteres via DKP Mimetics to Probe Structural Requirements of Peptide Transporter
Ayumu Niida, Shinya Oishi, Makiko Mizumoto, Yoshikazu Sasaki, Kenji Tomita, Hirokazu Tamamura, Akira Otaka, Tomohiro Terada, Ken-ichi Inui, Nobutaka Fujii

86. Development of New Photoremovable Amino Protecting Group and its Application toward Chemical Synthesis of 7TM-GPCR
Satoshi Ueda, Akira Otaka, Hirokazu Tamamura, Nobutaka Fujii

87. Multivalent Peptide Dendrimers: Native Chemical Ligation as a Synthetic Tool
Hinke Malda, Tilman M. Hackeng, Marcel H. P. Genderen, Egbert W. Meijer

88. Synthesis and Use of C-terminally Biotinylated Peptidomimetics with High Grb2 SH2 Domain-binding Affinity
Zhen-Dan Shi, Benedetta Peruzzi, Pathirage G. Dharmawardana, Tiffany Leech, Ettore Appella, Karen M. Worthy, Lakshman K. Bindu, Robert J. Fisher, Donald P. Bottaro, Terrence R. Burke

89. Total Solid Phase Synthesis of a Marine Cyclodepsipeptide IB-01212
Luiz J. Cruz, Marta Martínez, Julia Pérez, Marta Trujillo, Librada M. Cañedo, Ricard Rodríguez, Ernest Giralt, Fernando Albericio

90. Interference with Protein-Protein Interactions Involved in Protease Inhibitor Complex Formation
Dirk-Jan Zoelen, Maarten R. Egmond, Roland J. Pieters, Rob M. J. Liskamp

91. Sequence-Enabled Reassembly (SEER) Peptides for the Detection of DNA Sequences
Aik T. Ooi, Cliff I. Stains, Jason R. Porter, Indraneel Ghosh, David J. Segal

92. A Mild Acidic Method for the Selective Deprotection of N1-trityl-3a-hydroxypyrrolo[2,3-b]indole Derivatives
Jonathan P. May, David M. Perrin

93. Enantiomerically Pure H-Arg(Z)2-aldehyde Diethylacetal: A Useful Building Block in the Synthesis of Peptide Aldehydes
Fritz Dick, Juergen Gerhardt, Barbara Jakobi, Beat Sax, Joachim Schwindling, Christian Staehelin

94. Chlorotrityl Chloride (CTC) Resin as a Convenient Reusable Protecting Group
Fayna GarcÍa-MartÍn, Nuria Bayo, Luis J. Cruz, James Bohling, Fernando Albericio

95. Synthesis and Purification of Multiphosphorylated Peptides
Vladimir V. Kalashnikov, Yongping Tang, Jeanick H. Pascal

96. Dealing with the Aggregation Problem of Polyglutamine Peptides: Synthesis Strategies
Myriam Létourneau, Martin Viau, Ariane Sirois, Yvan Boulanger, Alain Fournier

97. Synthesis and Biological Assessment of Insulin-Like Analogs with Differential Activity at the Insulin and IGF-1 Receptors
Richard D. DiMarchi, Jie Han, Amy Hoffman, Vasily M. Gelfanov, Wayne Kohn, Radmila Micanovic, John P. Mayer

98. Biosynthesis of the Cyclotide Kalata B1 using Protein Splicing Tools
Richard Kimura, Krish Krishnan, Julio A. Camarero

99. Exploration and Elaboration of Reported Insulin Superagonism through Site-Selective Replacement at TyrB26
David L. Smiley, Ma Boaquan, Vasily M. Gelfanov, Richard D. DiMarchi

100. Synthesis of an RNase B 30—124 Glycoform by Native Chemical Ligation
Christian Piontek, Stefano Mezzato, Daniel Varon, Nelson Lombana, Manuela Schaffrath, Andreas Martin, Franz-Xaver Schmid, Carlo Unverzagt

101. Threaded Rings and Complex Topologies in Antimicrobial Peptides: Nature’s Engineering Templates
David J. Craik, K. Johan Rosengren, Lillian Sando, Shane S. Simonsen

102. A Minimalist Approach to Antimicrobial Proteins with Thionin as a Template
Miquel Vila-Perelló, Sabrina Tognon, Andrea Sánchez-Vallet, Antonio Molina, David Andreu

103. Discovering Additional Chemical and Biological Functions for 3-Oxo-N-Acylhomoserine Lactones
Gunnar F. Kaufmann, Rafaella Sartorio, Sang-Hyeup Lee, Claude J. Rogers, Michael M. Meijler, Jason A. Moss, Bruce Clapham, Andrew P. Brogan, Tobin J. Dickerson, Kim D. Janda

104. Comparing Antimicrobial and Membrane Permeabilizing Activity of Peptides Derived from Human Cationic Proteins
Susana Sánchez-Gómez, Guillermo MartÍnez Tejada, José Leiva-Leon, Ignacio Moriyón, Dagmar Zweytick, Karl Lohner, Sylvie E. Blondelle

105. Preliminary NMR Analysis of ProP440–500 the C-Terminal Cytoplasmic Domain of Bacterial Osmosensory Protein ProP
David L. Zoetewey, David N. M. Jones, Janet M. Wood, Robert S. Hodges

106. Synthesis and Conformation of Analogs of the Antiviral Peptide Halovir A
Andrea Bona, Cristina Peggion, Fernando Formaggio, Bernard Kaptein, Quirinus B. Broxterman, Claudio Toniolo

107. Total Synthesis in Solution and Preliminary Conformational Analysis of TOAC-Labeled Alamethicin F50/5 Analogs
Micha Jost, Cristina Peggion, Fernando Formaggio, Claudio Toniolo

108. A Lipid Monolayer Made Permeable to Tl(I) Ions by the Lipopeptaibol Trichogin GA IV
Chiara Baldini, Cristina Peggion, Ester Falletta, Maria Rosa Moncelli, Rolando Guidelli, Claudio Toniolo

109. A Universal Influenza B Peptide Vaccine
Paolo Ingallinella, Elisabetta Bianchi, Xiaoping Liang, Marco Finotto, Michael Chastain, Jiang Fan, Tong-Ming Fu, Hong Chang Song, Melanie Horton, Daniel Freed, Walter Manger, Emily Wen, Li Shi, Roxana Ionescu, Colleen Price, Marc Wenger, Emilio Emini, Riccardo Cortese, Gennaro Ciliberto, John Shiver, Antonello Pessi

110. Design, Synthesis and Analysis of a Cysteine-Deleted Analog of the Antimicrobial Peptide Tachyplesin-I
Deborah L. Heyl, Kiran Kumar Gottipati, Sreeja Sreekumar, Sathan Thennarasu, Ayyalusamy Ramamoorthy

111. Progress toward Total Solid-Phase Synthesis of Cyclic Lipodepsipeptide Antibiotic Fusaricidin A
Rekha Rawat, Ralph T. Martello, Pierre Y. Jean-Charles, Predrag Cudic

112. Biological and Structural Characterization of a New Linear Gomesin Analog
Marcos A. Fázio, Laurence Jouvensal, Françoise Vovelle, Philippe Bulet, M. Terêsa M. Miranda, Sirlei Daffre, Antonio Miranda

113. Monomeric Analogs of Halocidin
Xavier Doisy

114. Fragment of Human Lysozyme Conjugated on the N-terminus and Displaying Antibacterial Properties
Xavier Doisy

115. Synthesis and Raman Spectroscopy Studies of the Antimicrobial Peptide Cecropin B2
Susanne Ladefoged Nielsen, Xavier Doisy

116. Alamethicin Interaction with Lipid Membranes: A Spectroscopic Study on Synthetic Analogs
Lorenzo Stella, Marcello Burattini, Claudia Mazzuca, Antonio Palleschi, Mariano Venanzi, Cristina Peggion, Claudio Toniolo

117. Design of Bactericidal Self-Assembling Cyclic D,L-a-Glycopeptides
Shai Rahimipour, Leila Motiei, Reza M. Ghadiri

118. HB-50: A Pre-Clinical Study of a Prophylactic for Wound Infection
Scott M. Harris, Lijuan Zhang, Jody Parente, George T. Rodeheaver, Timothy J. Falla

119. Designer Multifunctional Antimicrobial Peptides Kill Fluoroquinolone-Resistant Clinical Isolates
Laszlo Otvos, John D. Wade, Feng Lin, Barry A. Condie, Christine Snyder, Jorg Hanrieder, Ralf Hoffmann

120. Solution Structures of Stomoxyn and Spinigerin, Two Antimicrobial Peptides from Insects
Celine Landon, Herve Meudal, Nathalie Boulanger, Philippe Bulet, Reto Stöcklin, Françoise Vovelle

121. Rational Design of a-Helical Antimicrobial Peptides
Yuxin Chen, Michael Guarnieri, Michael Vasil, Robert S. Hodges

122. Dimer Formation of Novel Cationic Antimicrobial Peptides in Membrane Environments
Evgenia Glukhov, Charles M. Deber

123. Enzymatic Incorporation of Prenyl Azides into Peptides and Proteins: Tools for Selective Protein Labeling
Juhua Xu, Stepan Lenevich, Jason Boggs, Daniel G. Mullen, George Barany, Mark D. Distefano

124. N-Alkylaminooxy Amino Acids as Versatile Derivatives for “Post-Translational” Modifications of Synthetic Peptides
Michael R. Carrasco

125. Improved Synthesis of 5-hydroxylysine (Hyl) Derivatives
Mare Cudic, Janelle L. Lauer-Fields, Gregg B. Fields

126. Synthesis and Biological Assessment of Sulfonic Acid-Based Glucagon Antagonists
Bin Yang, Vasily M. Gelfanov, Richard D. DiMarchi

127. Thioester Bond Liability: Study on Natural Influenza and Model Acylpeptides
Marina V. Serebryakova, Larisa V. Kordyukova, Boris V. Vaskovsky, Ludmila A. Baratova

128. Chemical Synthesis of MUC2 Tandem Repeat Model Carrying Multiple O-GalNAc Moieties
Hironobu Hojo, Yoshiyuki Matsumoto, Yoshiaki Nakahara1, Yusuke Suzuki, Minoru Suzuki, Akemi Suzuki

129. Site Specific Introduction of Unnatural Amino Acids at Sites Critical to Insulin Receptor Recognition and Biological Activity
Beili Quan, David L. Smiley, Vasily M. Gelfanov, Richard D. DiMarchi

130. Target-Based Proteolytic Profiling for Characterizing Cancer Progression
Janelle L. Lauer-Fields, Dmitriy Minond, Diane Baronas-Lowell, Michael J. Chalmers, Scott A. Busby, Patrick R. Griffin, Hideaki Nagase, Gregg B. Fields

131. From Simple Consensus Peptides to High Affinity Ligands: A Stepwise Diversity Oriented Strategy for the Acquisition of Potent Signaling Inhibitors
David S. Lawrence

132. Cyclic Modular ß-Sheets
James S. Nowick, Justin O. Brower, Omid Khakshoor, Wade A. Russu, R. Jeremy Woods

133. Apolipoprotein A-I Mimetic Peptides
G. M. Anantharamaiah, Mohamad Navab, Sreenivas T. Reddy, Susan Hama, Greg Hough, Mayakonda N. Palgunachari, Manjula Chaddha, Geeta Datta, David W. Garber, Alan M. Fogelman

134. Understanding BBB Transport using Glycosylated Enkephalins and Endorphins
Dhana Muthu, Isabel Alves, Charles M. Keyari, Larisa Yeomans, Richard D. Egleton, Jean M. Bidlack, Henry I. Yamamura, Victor J. Hruby, Edward J. Bilsky, Robin Polt

135. Design and Study of Novel Peptide Inhibitors against the SARS-Coronavirus Spike Protein
Zhe Yan, Brian Tripet, Robert S. Hodges

136. Screening Biosynthetic Peptide Libraries for Antimicrobial Activity
Lisa O. Nilsson, Mostafa Louassini, Ernesto Abel-Santos

137. Cellular Delivery and Design of Proprotein Convertase Inhibitors
Ajoy Basak, Xiaolei Hao, Ying Feng, Dayani Mohottalage, Farzaneh Lotfipour, Sarmistha Basak

138. Mechanism of Interaction between the (17–31) Binding Domain of PTH and the PTH Receptor
Thomas Dean, Ashok Khatri, Zhanna Potetinova, Gordon Willick, Thomas J. Gardella

139. [3,3]-Sigmatropic Rearrangments, and Chiral Aziridines for the Asymmetric Synthesis of Novel Amino Acids
Hongchang Qu, Lu Liu, Xuyuan Gu, Victor J. Hruby

140. A Library of Cysteine-Biotine Derivatives Useful for Pretargeting Avidin-Biotin Radioimmunoscintigraphy
Cristina Bolzati, Andrea Caporale, Davide Carta, Liliana Cofano, Elisabetta Schievano, Francesco Tisato, Fiorenzo Refosco, Evaristo Peggion, Giuliano Bandoli

141. A Methionine Scan of Region [168–176] of the Parathyroid Hormone Receptor 1 — The “Magnet Effect”
Angela Wittelsberger, Beena E. Thomas, Dale F. Mierke, Michael Rosenblatt

142. A New Approach to the Synthesis of Policyclic Dipeptide Derivatives as Potential Antitumoral Agents
Teresa Lama, Orazio Mazzoni, Pietro Campiglia, Alessia Bertamino, Ettore Novellino, Maria V. Diurno, Isabel Gomez-Monterrey, Antonio Mazzella Bosco, Paolo Grieco

143. A Purification Strategy for Synthetic Peptides that Utilizes pH to Optimize Selectivity
Andrew F. Coffey, Linda L. Lloyd, Keeley J. Mapp, Louise E. Rochell, Alasdair MacDonald

144. Agonist Activation of the Angiotensin II Type 1 Receptor Alters the Spatial Proximity of Transmembrane Domain 7 to the Ligand Binding Pocket
Dany Fillion, Gaétan Guillemette, Richard Leduc, Emanuel Escher

145. An Asymmetric Synthesis of (R)- and (S)-o-cyano-phenylalanine Leading to Chiral Constrained Phenylalanine Dipeptide Mimetics
Karolien Rompaey, Isabelle Eynde, Steven Ballet, Dirk Tourwé

146. Analogs of Multifunctional Ligands for Opioid and CCK Receptors
Ekaphol Wooden, Vinod Kulkarni, Yeon S. Lee, Richard S. Agnes, Christine Salibay, Peg Davis, Shou-Wu Ma, Josephine Lai, Frank Porreca, Victor J. Hruby

147. Antigen Effects of Peptide Nucleic Acids on HIF-1a Expression
Zhanna Zhilina, Amy Ziemba, Lenka Stankova, Stacey Wood, Meghan Boros, Scot Ebbinghaus

148. Novel Glyco-lipid-arsenicals (III) with Anti-proliferative Effects on MCF-7 Human Breast Cancer Cells
Norbert Wimmer, Jodie A. Robinson, Nagaraj Gopisetty-Venkatta, Sarah J. Roberts-Thomson, Gregory R. Monteith, Istvan Toth

149. Antisense PNA and PNA-peptide Conjugates for the Modulation of ß-globin Gene Splicing
Alessandra Romanelli, Soccorsa Pensato, Erminia Niola, Giordana Feriotto, Francesca Salvatori, Giulia Breveglieri, Laura Zaccaro, Michele Saviano, Roberto Gambari, Carlo Pedone, Ettore Benedetti

150. ß-Amino Acid Analogs of an Insect Neuropeptide
Pawel Zubrzak, Howard J. Williams, Geoffrey M. Coast, Gloria Reyes-Rangel, Eusebio Juaristi, Janusz Zabrocki, Allison Strey, Ronald J. Nachman

151. Branched Neurotensin for Tumor Targeting
Chiara Falciani, Monica Fabbrini, Barbara Lelli, Luisa Lozzi, Alessandro Pini, Luisa Bracci

152. CCK/MSH Analogs and Derivatives for Imaging and Incorporation in Multimeric Ligands
Rajesh Sankaranarayanan, Fang Gao, Jatinder S. Josan, Heather Handl, Josef Vagner, Robert J. Gillies, Victor J. Hruby

153. Cellular Uptake of Pyrrolidine-Based Oxy-Peptide Nucleic Acid
Mizuki Kitamatsu, Rino Matsuzaki, Masahiko Sisido

154. Chemical Biology and Biomedical Application of Synthetic Molecules Targeted to Apoptosis Regulated by the Bcl-2 Family
Jun Wang, Dongxiang Liu, Krishna Kumar, Aihua Nie, Yohichi Kumaki, Pak-Nei Hon, R. Wayne Fritzsche, Jing An, John C. Reed, Ziwei Huang

155. Comparative Immunogenicity of Common and Rare HIV Mutant Peptides
Sylvie E. Blondelle, Rosa Moya, Kim Schroder, Darcy B. Wilson

156. Conformational Studies of Agouti-Related Protein (AGRP)-Melanocortin Chimeric Peptides
Andrzej Wilczynski, Krista R. Wilson, Joseph W. Scott, Arthur S. Edison, Carrie Haskell-Luevano

157. C-Terminal Ether Analogs of NN703
Kjeld Madsen, Peter Andersen, Michael Ankersen, Bernd Peschke, Birgit Sehested, Jan Soerensen

158. Cyclic Statine-based Peptides as Inhibitors of ß-Secretase
Alessandra Barazza, Marion Götz, Christian Renner, Michael Willem, Luis Moroder

159. Design and Structure Determination of a Selenium Labeled Antimicrobial Peptide
Xiaomei Zhou, Phat L. Tran, Joe Fralick, Ted W. Reid

160. Design and Synthesis of Encoded One-bead One-compound Peptidomimetic Libraries for Identification of a4ß1 Integrin Ligands
Ruiwu Liu, Li Peng, Jan Marik, Kit S. Lam

161. Design and Synthesis of Histone Deacetylase Inhibitors by Side Chain Modification of 2-Amino-(n-1)-alkenoic Acids
Mohammed P. I. Bhuiyan, Tamaki Kato, Norikazu Nishino

162. Design of a Library of Histone Deacetylase Inhibitors Based on Chlamydocin
Norikazu Nishino, Mohammed P. I. Bhuiyan, Yoshinori Hirashima, Louis A. Watanabe, Priti Soni, Tamaki Kato, Tomonori Nishino, Minoru Yoshida

163. Design of an Antibody for Early Detection of Ovarian Cancer
Danielle Carbin, Sharad Rawale, Carl Morrison, Jeffrey Fowler, Larry Maxwell, Pravin T. P. Kaumaya

164. Design, Synthesis and Applications of Cell-penetrant Peptides as Signal Transduction Modulators
John Howl, Michelle Farquhar, Sarah Jones

165. Novel MTII/AGRP Hybrid Analogs that Lead to Selective Ligands for the Human Melanocortin Receptors
Minying Cai, Alexander Mayorov, Kevin Chandler, Christopher Cabello, Dustin Tanaka, Dev Trivedi, Victor J. Hruby

166. Design, Synthesis, and Evaluation of Gluten Peptide Analogs as Selective Inhibitors of Human TG2
Olga Fierro, Stefania Albrizio, Alfonso Carotenuto, Gabriella Caliendo, Daniela Guarino, Paolo Grieco, Pietro Campiglia, Teresa Lama, Ettore Novellino

167. Novel Blue- and Red-Shifted Internally Quenched Fluorogenic Substrates for Continuous Monitoring of SARS-CoV 3CLpro
Pamela Hamill, Martin Richer, Derek Hudson, Hongyan Xu, François Jean

168. Discovery and Optimization of a TRAIL R2 Agonist for Cancer Therapy
Yvonne M. Angell, Ashok Bhandari, Anjan Chakrabarti, M. Nuria Francisco, Amy N. Duguay, Brian T. Frederick, Karen Leu, Kerstin Leuther, Xianfeng Li, Kalyani Penta, Sunila Piplani, Reuben Sana, Erik A. Whitehorn, Pete J. Schatz, Kevin Yin, Christopher P. Holmes

169. Development of Peptide Vaccines against HPV-16 Associated Cervical Cancer and Group A Streptococci
Peter M. Moyle, Aniko Horváth, Levente Karpati, Colleen Olive, Nadia Barozzi, Norbert Wimmer, Michael Good, Istvan Toth

170. Disulfide as a Constraint to Build Super Potent and Selective Melanocortin-4 Receptor (MC4R) Agonists
Zeng Yan Liang, David Flora, Patrick Edwards, David L. Smiley, Paul J. Emmerson, Hansen M. Hsiung, Robert Gadski, JeAnne Hertel, Mark L. Heiman, Saba Husain, Thomas P. O’Brien, Steven D. Kahl, Lianshan Zhang, Richard D. DiMarchi, John P. Mayer

171. Effect of Dimerization and Tetramerization on the Potency of HIV-1 Integrase Inhibitory Peptides
Krzysztof Krajewski, Christophe Marchand, Yves Pommier, Peter P. Roller

172. The Effects of Stable Bradykinin Receptor 2 Agonist B9972 on Pulmonary Vasculature in vitro and vivo
Laimute Taraseviciene-Stewart, John M. Stewart, Lajos Gera, Nana Burns, Robertas Scerbavicius, Norbert F. Voelkel

173. Etk/Bmx Tyrosine Kinase Peptide Substrates and Inhibitors Derived from the Autophosphorylation Site of the Enzyme
Ching-Yi Hsieh, Jan Marik, Jenny Kung, Coleen Sweeney, Kit S. Lam, Hsing-Jien Kung

174. Fluorescence Resonance Energy Transfer Substrates for Determining Cathepsin B pH Specificity
Paolo Ruzza, Luigi Quintieri, Alessio Osler, Andrea Calderan, Barbara Biondi, Maura Floreani, Andrea Guiotto, Gianfranco Borin

175. Ghrelin Attenuates Burn-induced Cachexia
Ambikaipakan Balasubramaniam, Rashika Joshi, Chunhua Su, Lou Ann Friend, James H. James

176. High Affinity High Specificity a4ß1 Integrin Targeting Peptidomimetics for Lymphoid Cancers
Li Peng, Ruiwu Liu, Xiaobing Wang, Jan Marik, Yoshikazu Takada, Kit S. Lam

177. Highly N-Methylated Somatostatin Analogs: Synthesis, Biological Activity and Structure-Activity Relationship Studies
Eric Biron, Daniel Langenegger, Daniel Hoyer, Horst Kessler

178. Highly Sensitivity FRET Substrate for Assay of HCV Protease
Xiaohe Tong, Ling Sheng, Xiaofen Zhong, Yi Tang, Junge Lu, Zhenjun Diwu, Anita Hong

179. Identification and Characterization of Synthetic Peptide Substrates and Small Molecule Inhibitors of Non Receptor Tyrosine Kinase Etk
Lauren Lee, Ruiwu Liu, Nianhuan Yao, Jan Marik, Ching-Yi Hsieh, Hsing-Jien Kung, Kit Lam

180. Identification of High Affinity Anti-MCP-1 Antibodies using Synthetic Proteins
Marian Kruszynski, Ping Tsui, Jinquan Luo, Anuk Das1, Nicole Stowell, Michael Brigham-Burke, Jennifer F. Nemeth, Li Yan, Heena Beck, Jil Carton, Raymond Sweet, George A. Heavner, Michael Bardroff, Daniela D. Ducata, Ute Jager, Robert Rauchenberger

181. Mapping Cell Binding using Collagen III “Toolkit”
Nicolas F. Raynal, Tony Peachey, Richard W. Farndale

182. Modeling of a1 Adrenergic Receptors: the Application in the Design of Selective a1B-Adrenergic Antagonists
Slavica Eri, Tomaž Šolmajer, Marko Oblak, Miha Kotnik, Danica Agbaba

183. Characterization of the Interaction of HIP Analog Peptide with Heparin
Jing Wang, Dallas Rabenstein

184. New Urotensin-II Analogs Modified at Position 4
Paolo Grieco, Pietro Campiglia, Alfonso Carotenuto, Teresa Lama, Ettore Novellino, Paolo Rovero, Guido Iaccariono

185. New Urotensin-II Analogs with a Constrained Trp-7 Side Chain
Alfonso Carotenuto, Paolo Grieco, Pietro Campiglia, Teresa Lama, Ettore Novellino, Paolo Rovero, Guido Iaccarino

186. Novel GnRH Antagonists Derived from Degarelix: Exploration of the GnRH Antagonist Pharmacophore
Manoj P. Samant, Doley J. Hong, Glenn Croston, Catherine Rivier, Jean Rivier

187. Novel Neuroprotective Neurotrophic NAP Analogs Targeting Iron Toxicity and Oxidative Stress in Neurodegenerative Diseases
Hailin Zheng, Dan Blat, Moussa B. H. Youdim, Lev M. Weiner, Dudy Dangoor, Ilana Gozes, Mati Fridkin

188. One-bead One-compound: Different Type of Screening Assays for Anti-bacterial Adhesion
Yanlei Liu, Li Peng, Xiaobing Wang, Kit S. Lam, Joseph W. Leung

189. Peptide - Mediated Delivery of siRNA via Noncovalent Complexes and Covalent Conjugates
Renata T. Witkowska, Mohammad Ahmadian, James W. Dattilo, Lafe J. Purvis, Sasha J. Mayer, Lishan Chen, Yuching Chen, Kunyuan Cui, Ken W. Farber, Sharin E. Roth, Michael E. Houston, Paul H. Johnson, Steven C. Quay

190. Peptides Reproducing the ApoA-I 141–164 Region: Studies on Hpt Recognition
Luca D. D’Andrea, MariaStefania Spagnuolo, Angela Stefano, Marianna Morra, Alessandro Carlucci, Annarita Gatto, Pasqualina Caso, Carlo Pedone, Paolo Abrescia, Ettore Benedetti

191. Peptidomimetic Inhibitors of Platelet Adhesion as Potential Novel Antiplatelet Agents
Vivienne Buckley, Elise Bernard, Edelmiro Moman, Lorraine Coleman, Dermot Kenny, Marc Devocelle

192. Peptidyl-based Delivery Systems as a Strategy for the Therapeutic Intervention of Human Astrocytoma and Medulloblastoma
Sarah Jones, John Howl

193. Photolabeling with N-Terminal Urotensin II Photoprobes Identifies Methionine 288 of Rat Urotensin Receptor as a Contact Point
Brian J. Holleran, Christophe Proulx, Marie-Ève Beaulieu, Emanuel Escher, Richard Leduc

194. Protein Kinase C Isoform (PKC) Peptide Activator/Inhibitors Exert Cardioprotective Effects in Polymorphonuclear Leukocyte (PMN)-induced Ischemia/Reperfusion (I/R) Injury
Lindon H. Young, Aisha Phillipson, Didi Omiyi, Norrell Atkinson, Manoj Jivani, Jovan Adams, Ellen E Peterman, Philip Taormina, Richard J. Brue, Margaret Harvey

195. Rational Design of Small Molecules for a Novel Class of Anti-Cancer Drugs using a Phenylalanine Library
Lajos Gera, Daniel C. Chan, Laimute Taraseviciene-Stewart, Vitalija Simkeviciene, Paul A. Bunn, John M. Stewart

196. Repair of Photodamaging Effects on Human Melanocytes by 4-Phenylbutryl-His-D-Phe-Arg-Trp-NH2. A Superpotent Analog of a-Melanocortin
James J. Knittel, Leonid N. Koikov, Pilgrim Jackson, Glenn Milhauser, Ana Luisa Kadekaro, Renny J. Kavanagh, Zalfa Abdel-Malek

197. RGD Peptide-Labeled Quantum Dots for Integrin avß3 Targeting
Weibo Cai, Xianzhong Zhang, Yun Wu, Xiaoyuan Chen

198. Rigid Cyclic Tetrapeptides as Probes and Mimics of Reverse Turns
Sage Berg-Cross, Garland Marshall

199. Solid-Phase Synthesis and Structure Characterization of N'-Biphenyl-N-2-Ethylbutyl-Demethylvancomycin
Nian-Huan Yao, James R. Carlson, Gang Liu, Kit S. Lam

200. Stereo-controlled Synthesis of [L-Arg, L/D-3-(2-Naphthyl)alanine]-type (E)-Alkene Dipeptide Isosteres and its Application to the Preparation and Biological Evaluation of Peptidomimetic Analogs of the CXCR4 Antagonist FC131
Hirokazu Tamamura, Kenichi Hiramatsu, Satoshi Ueda, Zixuan Wang, John O. Trent, Stephen C. Peiper, Naoki Yamamoto, Hideki Nakashima, Akira Otaka, Nobutaka Fujii

201. Stochiometric Inhibition of ß-Amyloid Fibrillogenesis using Ca,a-Disubstituted Amino Acid Containing Peptides
Marcus A. Etienne, Cyrus Bett, Jed P. Aucoin, Tim J. Jensen, Robin L. McCarley, Ted Ajmo, Donna Herber, David Morgan, Robert P. Hammer

202. Structure Determination of the Human Angiotensin II Receptor Type 1 by the Methionine Proximity Assay
Martin Clément, Stéphane S. Martin, Caroline Chamberland, Marie-Ève Beaulieu, Richard Leduc, Gaétan Guillemette, Emanuel Escher

203. Structure-Activity Relationship Studies of a Novel CXCR4 Chemokine Antagonist Reveal Unique Activity Profile
Celia Amela-Cortés, Martha Rezende, Tatyana Yakovleva, Dan Papa, Elisabeth Perchellet, Jean-Pierre Perchellet, Sandra C. Vigil-Cruz

204. Studies on a Mutual Prodrug of Sulfamethoxazole and Nalidixic acid
Asif Husain, M. S. Y. Khan

205. Studies on Interaction of CaM with CaM-Binding Peptides M13 and RS20 in the Presence of Al3+ Ions
Andrea Calderan, Paolo Ruzza, Alessio Osler, Andrea Guiotto, Barbara Biondi, Gianfranco Borin

206. Studies on the Peroxidase Mimetic Peptide
Liping Wang, Xiaoming Zhao, Lili Guo, Roger W. Roeske, Wei Li

207. Use of Combinatorial Peptide Libraries and LC/MS/MS to Study TPP I Substrate Specificity
Yu Tian, Istvan Sohar, John W. Taylor, Peter Lobel

208. Sunflower Derived Trypsin Inhibitors as Anti-Metastatics
Peter P. Roller, Sheng Jiang, Peng Li, Ya-Qiu Long, Sheau-Ling Lee, Cheng-Yong Lin, Michael Johnson, Richard B. Dickson

209. Surface Plasmon Resonance- and Quartz Crystal Microbalance-based Methods for Detecting GRB2 SH2 / Peptide Interaction
Feng-Di T. Lung, Wan Ching Li, Chien-Chung Liou

210. Synthesis and Biological Activity of Terlipressin and its Putative Metabolites
Kazimierz Wisniewski, Sudar Alagarsamy, Hiroe Taki, Marcel Miampamba, Regent Laporte, Robert Galyean, Glenn Croston, Claudio Schteingart, Pierre Riviere, Jerzy Trojnar

211. Synthesis and Evaluation of Neuroprotective a,ß-Unsaturated Aldehyde Scavenger Histidyl-containing Analogs of Carnosine
Andrea Guiotto, Andrea Calderan, Paolo Ruzza, Alessio Osler, Chiara Rubini, Dong-Gyu Jo, Sung-Chun Tang, Thiruma V. Arumugam, Mark P. Mattson, Gianfranco Borin

212. Synthesis, Structural Characterization and Reactivity Study of Humanin, an Alzheimer’s Disease Associated Peptide
Madalina Maftei, Heiko Moeller, Xiaodan Tian

213. Synthesis of 4-amino-1,2,4,5-tetrahydro-2-benzazepine-3-ones and Study of their ß-turn Inducing Properties
Isabelle Eynde, Karolien Rompaey, Steven Ballet, Rien Wachter, Kenno Vanommeslaeghe, Monique Biesemans, Rudolph Willem, Dirk Tourwé

214. Synthesis of a RGD Peptide-PEG Hybrid for Carrying Adenovirus Vector into Cells
Shinya Kida, Mitsuko Maeda, Keiko Hojo, Yusuke Eto, Jian-Qing Gao, Shinnosuke Kurachi, Fumiko Sekiguchi, Hiroyuki Mizuguchi, Takao Hayakawa, Tadanori Mayumi, Shinsaku Nakagawa, Koichi Kawasaki

215. Synthesis of Cyclic Imino Acids from a-Amino-?-Bromoalkanoic Acids
Louis A. Watanabe, Mohammed P. I. Bhuiyan, Tamaki Kato, Norikazu Nishino

216. Synthesis of Quantum Dots Labeled Short Peptides and their Application in Imaging the T Cell Surface Receptors
Lifeng Wang, Jie Chen, Liping Wang, Chunlei Wang, Wei Li

217. Synthesis of Quantum Dot-Signal Peptides Bioconjugates and Targeting in Living Cells
Yaming Shan, Jiayue Hu, Liping Wang, Wei Li

218. Synthesis of Symmetrical Dimeric Dicarboxylic Acid Linked Peptides on Solid Support
Sheng Jiang, Zaneta Nikolovska-Coleska, Shaomeng Wang, Peter P. Roller

219. Systematic Study on the Structure-Activity Relationship of Pyrazinone Ring-Containing Bioactive Opioid Ligands
Kimitaka Shiotani, Anna Miyazaki, Tingyou Li, Yuko Tsuda, Toshio Yokoi, Akihiro Ambo, Yusuke Sasaki, Yunden Jinsmaa, Sharon D. Bryant, Lawrence H. Lazarus, Yoshio Okada

220. Tetra and Pentapeptide Derivatives of Hemiasterlin. Synthesis and Activity Studies
Marcin Dyba, Nadya I. Tarasova, Teresa Kosakowska-Cholody, Ernest Hamel, Christopher J. Michejda

221. The Chemo-enzymatic Synthesis of Oligosaccharide-linked Peptides Aimed at Improved Drug Delivery
Ken D. Johnstone, Manuela Dieckelmann, Michael P. Jennings, Joanne T. Blanchfield, Istvan Toth

222. Neokyotorphin as Cell Protein Kinase Affector
Olga V. Sazonova, Elena Yu. Blishchenko, Anna G. Tolmazova, Dmitry P. Khachin, Andrei A. Karelin, Vadim T. Ivanov

223. Towards Inhibition of Amyloid ß-protein Oligomerization
Sean M. Spring, Summer L. Bernstein, Noel D. Lazo, Brigita Urbanc, H. Eugene Stanley, Michael T. Bowers, David B. Teplow, Gal Bitan

224. Use of Betidamino Acids in Drug Design
Judit Erchegyi, Sandra Wenger, Beatrice Waser, Veronique Eltschinger, Renzo Cescato, Jean Claude Reubi, Steven C. Koerber, Christy R. R. Grace, Roland Riek, Jean E. Rivier

225. Helical Peptide Analogs of gp41 to Develop an HIV Vaccine
Florence M. Brunel, Michael B. Zwick, Ian A. Wilson, Dennis R. Burton, Philip E. Dawson

226. Structure-Activity Relationship Studies of a Novel AGRP-Melanocortin Chimeric Template
Krista R. Wilson, Andrzej M. Wilczynski, Joseph W. Scott, Rayna M. Bauzo, Carrie Haskell-Luevano

227. Synthesis and Pharmacological Evaluation of a New Generation of TIPP-Derived Dual-Labeled Ligands for Delta Opioid Receptors
Xin Wang, Thomas F. Murray, Jane V. Aldrich

228. Synthesis and Pharmacological Evaluation of Dual Labeled Delta Opioid Receptor Peptides
Angela M. Peck, Vivek Kumar, Thomas F. Murray, Jane V. Aldrich

229. Novel Retro-inverso Envelope Peptide Mimetic Fusion Inhibitors as a Potential Therapy for HTLV-1 Infected Individuals
Marcus P. Lynch, Sharad V. Rawale, Ahmed A. Behery, William P. Hudleson, Norihiro Takenouchi, Karen Yao, Steven Jacobson, Pravin T. P. Kaumaya

230. Heteroclitic Analogs Derived from the HTLV-1 Gag Antigen Increase Cytolytic and IFN-? Responses in HLA-A*0201 Transgenic Mice
Marcus P. Lynch, Jacqueline C. Lieblein, Sharad V. Rawale, Danielle M. Carbin, Pravin T. P. Kaumaya

231. Development of a Monoclonal Antibody Therapeutic for the Prevention and Treatment of Pseudomonas aeruginosa Infection
Daniel J. Kao, Robert S. Hodges

232. An Unexpected Side Reaction Involving the Deletion of an Acetylated N-Methyl-Amino Acid from the N-terminus of Peptides
Wei-Jie Fang, Marco A. Bennett, Thomas F. Murray, Jane V. Aldrich

233. Synthesis and Biological Activities of Chimeric Bioactive Peptides Based on Amino Acids Coupled to 4-Anilino-N-Phenethyl-Piperidine
Ravil R. Petrov, Ruben S. Vardanyan, Shou-wu Ma, Peg Davis, Yeon S. Lee, Minying Cai, Frank Porreca, Josephine Y. Lai, Victor J. Hruby

234. Discovery of Potent mMC1R Agonists with Prolonged Activity at Human Melanocytes
Aleksandar Todorovic, Jerry R. Holder, Rayna M. Bauzo, Joseph W. Scott, Renny Kavanagh, Zalfa Abdel-Malek, Carrie Haskell-Luevano

235. ß-Hairpin Minimization and Optimization
Niels H. Andersen, Katherine A. Olsen, R. Matthew Fesinmeyer, Lisa A. Eidenschink

236. Analogs of Interleukin 8 Containing non Proteinogenic Segments Show High Biological Activity
Ralf David, Annette G. Beck-Sickinger

237. Optimization of the C-terminal Sequence in Glucagon to Maximize Receptor Affinity
Jay J. Levy, Vasily M. Gelfanov, Richard D. DiMarchi

238. Design, Synthesis, and Evaluation of Piperazine-Based Small Molecule Peptide Mimetics Targeting the Melanocortin Receptors
James P. Cain, Alexander V. Mayorov, Minying Cai, Yeon-Sun Lee, Jinfa Ying, Victor J. Hruby

239. Structure-Based Design and Structure-Activity Relationships of D-Phe-Pro-D-Arg-P1'-CONH2 Tetrapeptides Inhibitors of Thrombin
Cristina C. Clement, Philipp Manfred

240. A Gibberellin Mimetic Peptide Recognized by an Anti-gibberellin Monoclonal Antibody
Hikaru Hemmi, Takashi Murata, Shugo Nakamura, Kentaro Shimizu, Yoshihito Suzuki, Isomaro Yamaguchi

241. Synthesis of the Spin-labelled ß-Amino Acids cis- and trans-ß-TOAC, and a Preliminary Conformational Study of trans-ß-TOAC/trans-ACHC Peptides
Karen Wright, Matthieu Sarciaux, Michel Wakselman, Jean-Paul Mazaleyrat, Marco Crisma, Fernando Formaggio, Cristina Peggion, Antonio Toffoletti, Carlo Corvaja, Claudio Toniolo

242. High Affinity Grb2 SH2 Domain-Binding Macrocycles Derived from Ring-Closing Methathesis of Alkenylglyicne Residues with ß-Vinyl Phosphotyrosyl Mimetics
Fa Liu, Shinya Oishi, Rajeshri Karki, Zhen-Dan Shi, Karen M. Worthy, Lakshman K. Bindu, Melissa Maderia, Marc Nicklaus, Joseph J. Barchi, Robert J. Fisher, Terrence R. Burke

243. Towards Photo-Controlled Collagens
Ulrike Kusebauch, Sergio A. Cadamuro, Luis Moroder, Christian Renner

244. Template-Assembled Peptide Models of the N-Peptide Helix Bundle from HIV-1 gp41
Weiming Xu, John W. Taylor

245. Alignment of Three Nitroxide Radicals on the Same Face of a Helical Peptide Scaffold
Marco Crisma, Simona Oancea, Fernando Formaggio, Elena Sartori, Carlo Corvaja, Claudio Toniolo

246. Design, Synthesis, and Preferred Conformation of Peptides Based on a Highly Constrained, ß,ß'-Diphenyl Substituted Cyclopropane a-Amino Acid
Soledad Royo, Wim M. Borggraeve, Cristina Peggion, Marco Crisma, Ana I. Jiménez, Carlos Cativiela, Claudio Toniolo

247. Identification of a Novel HIV-1 Neutralizing Antibody Using Synthetic Peptides that Mimic a GP41 Fusion Intermediate
Elisabetta Bianchi, Michael D. Miller, Romas Geleziunas, Gaetano Barbato, Paolo Ingallinella, Marco Finotto, Renee Hrin, Meiqing Lu, Simon Lennard, David Lowe, Gennaro Ciliberto, Daria Hazuda, Riccardo Cortese, John Shiver, Antonello Pessi

248. Covalent Trimeric Coiled Coils of the HIV gp41 HR1 Region are Extremely Potent and Broadly Neutralizing Inhibitors of Viral Infection
Elisabetta Bianchi, Marco Finotto, Paolo Ingalinella, Renee Hrin, Michael D. Miller, Romas Geleziunas, Antonello Pessi

249. Selective Agonists for the Human Vasopressin V1b Receptor are Potent Antidiuretic Agonists in the Rat
Stoytcho B. Stoev, LingLing Cheng, Maurice Manning, Nga C. Wo, Hazel H. Szeto, Ana Pena, Brigitte Murat, Sylvain Derick, Miguel Trueba, Maria A. Ventura, Gilles Guillon

250. Prion Protein Misfolding: Conformational Stability of the a2-Helix
Pasqule Palladino, Luisa Ronga, Barbara Tizzano, Filomena Rossi, Raffaele Ragone, Teodorico Tancredi, Gabriella Saviano, Angelo Facchiano, Susan Costantini, Menotti Ruvo, Ettore Benedetti

251. Modeling Flexible Loops in the Dark-Adapted and Activated States of Rhodopsin, a Prototypical G-protein-Coupled Receptor
Gregory V. Nikiforovich, Garland R. Marshall

252. Deducing 3D Models of the Activated States for TM Regions of GPCRs by Modeling Constitutively Active Mutants: The Test Case of Opsin
Gregory V. Nikiforovich, Garland R. Marshall

253. Identification of a Unique Stability Propagation Site that Controls Protein Stability of a-Tropomyosin: a Two-Stranded a-Helical Coiled-coil
Janine B. Mills, Stanley C. Kwok, Lawrence B. Smillie, Robert S. Hodges

254. The Introduction of Uncharged a-Hydroxymethyl Amino Acid Residues in Substrate Specificity P1 Position of Trypsin Inhibitor SFTI-1 from Sunflower Seeds Retains its Activity
Ewa Zablotna, Agnieszka Kret, Anna Jaskiewicz, Aleksandra Olma, Miroslaw T. Leplawy, Krzysztof Rolka

255. Molecular Simulation of an a/?-Peptide Dendrimer
Qitao Yu, Yuguang Mu, Lars Nordenskiold, James P. Tam

256. A GHS-1a Receptor Agonist that is Highly Effective in Stimulating Body Weight Gain
Jesse Z. Dong, John Eynon, Jundong Zhang, John E. Taylor, Heather A. Halem, Rakesh Datta, Michael D. Culler

257. A Non-Competitive Peptide Agonist of GHSR1a Receptor Stimulates Growth Hormone Secretion and Food Intake
Abdelkrim Habi, Patric Delhanty, Daniel Abran, Aart Jan Lely, Krishna G. Peri

258. Development of µ Opioid Receptor Selective 4-Anilinidopiperidine Analogs
Yeon Sun Lee, Joel Nyberg, Sharif Moye, Richard Agnes, Adriano Mollica, Peg Davis, Shou-Wu Ma, Josephin Lai, Frank Porreca, Ruben Vardanyan, Victor J. Hruby

259. A Whole-Cell Binding Assay for Testing the Targeting Potential of Cyclic Peptide Ligands
Sonya Cressman, Ning Fang, David D. Y. Chen, Pieter R. Cullis

260. Synthesis and Evaluation of Chiral and Achiral a,a-Disubstituted Amino Acids as ß-Sheet Stabilizing Factors
Jia Wang, Robert P. Hammer

261. Evaluation of Malarial Protease Plasmepsin Inhibitors Containing Hydroxymethylcarbonyl Isostere
Koushi Hidaka, Tooru Kimura, Yumi Tsuchiya, Aiko Kiso, Yoshio Hayashi, Azin Nezami, Ernesto Freire, Yoshiaki Kiso

262. Design and Synthesis of ß-Secretase Inhibitors: Optimization at the P4 and P1' Positions
Yoshio Hamada, Daisuke Shuto, Naoto Igawa, Soko Kasai, Ping Liu, Koushi Hidaka, Tooru Kimura, Yoshio Hayashi, Shoichi Ishiura, Yoshiaki Kiso

263. Synthesis of Non-linear Potential Vaccines for HSV-1
Rosalba Mansi, Stefania Galdiero, Diego Tesauro, Ettore Benedetti, Giancarlo Morelli, Massiliano Galdiero

264. Intramolecular Triplet Quenching by Nitroxide Radicals as a Tool for Determining Peptide Secondary Structure in Solution
Lorenzo Stella, Gianfranco Bocchinfuso, Emanuela Gatto, Antonio Palleschi, Mariano Venanzi, Daniela Zavallone, Andrea Bettio, Fernando Formaggio, Claudio Toniolo, Basilio Pispisa

265. A Time-Resolved Spectroscopic Study on Peptide Folding
Basilio Pispisa, Emanuela Gatto, Gianfranco Bocchinfuso, Antonio Palleschi, Lorenzo Stella, Mariano Venanzi, Fernando Formaggio, Claudio Toniolo

266. Ion Channel Activities and Mechanisms of Ion Conduction about Cyclic Hexapeptides
Junichi Taira, Ryo Hayashi, Satoshi Osada, Tsuguhisa Ehara, Hiroaki Kodama

267. Synthesis and Biological Activities of Proline Rich Cyclic Heptapeptide Hymemanide B Analogs
Yasuhiro Shiki, Junichi Taira, Aya Nakamura, Satoshi Osada, Hiroaki Kodama

268. Synthesis and Biomaterials Application of Polymers Containing Pentapeptide and/or Hexapeptide Sequences Derived from Elastin
Kouji Okamoto, Shuichiroh Uehara, Kayoko Matsui, Maria Portia P. Briones, Iori Maeda, Masakazu Furuta

269. Synthesis and Biological Activities of fMLP Analogs Containing 2,3-Cyclopropane Amino Acid Derivatives
Daisuke Sugiyama, Ryo Hayashi, Hiroshi Kawasaki, Hiroaki Kodama, Satoshi Osada, Masafumi Zaitsu, Ichiro Fujita

270. pI-shifted Basal Insulin Analogs with High Selectivity for Insulin vs IGF-1 Receptor
Wayne D. Kohn, Radmila Micanovic, Sharon L. Myers, Andrew M. Vick, Steven Kahl, Lianshan Zhang, Beth Strifler, Shun Li, Jing Shang, John M. Beals, John P. Mayer, Richard D. DiMarchi

271. N-Backbone Methylations of Parathyroid Hormone (PTH) C-Terminal Region: Bioactivities and Implications for PTH-Receptor Complex
Zhanna Potetinova, Jean-René Barbier, Thomas J. Gardella, Thomas Dean, James F. Whitfield, Gordon E. Willick

272. N-Backbone Methylations of Parathyroid Hormone (PTH) C-Terminal Region: Effects on Structure
Zhanna Potetinova, Feng Ni, Gordon E. Willick

273. C-Terminal Modified Parathyroid Hormone: Effects on Structure and Activity
Zhanna Potetinova, Jean-Rene Barbier, Thomas Dean, Thomas J. Gardella, Gordon E. Willick

274. Spectroscopic Characterization of PEG-Amylin Derivatives
Giuseppe Impellizzeri, Diego Mendola, Antonio Magrì, Giuseppe Maccarrone, Giuseppe Pappalardo, Enrico Rizzarelli

275. Conformational Properties and Functional Role of VDAC N-Terminal Peptide
Vito Pinto, Angela Messina, Rita Aiello, Flora Tomasello, Diego Mendola, Antonio Magrì, Danilo Milardi, Giuseppe Pappalardo

276. Design of Membrane Active Peptides with Regularly Repeating Glycine or D-amino Acid Residues
Jyothi Thundimadathil, Roger W. Roeske, Lili Guo

277. Design and Synthesis of Novel a-MSH Peptide Analogs Highly Selective for the hMC4R
Victor J. Hruby, Jinfa Ying, Xuyuan Gu, Minying Cai, Josef Vagner, Dev B. Trivedi, Katalin E. Kövér

278. Design, Synthesis and Characterization of Conformational Peptides at the Interface of HER-2 Dimerization and Pertuzumab Binding
Joan T. Steele, Sharad Rawale, Pravin T. P. Kaumaya

279. Synthesis of a Phosphino Triple Helical Collagen Mimic
John K. Whitehead, Shunzi Li, LaKeisha N. Myles, Robert P. Hammer, Gregg B. Fields

280. Steric Hindrance of the HER-2/neu Dimerization Loop by Peptide Mimic Antibodies
Stephanie D. Allen, Sharad Rawale, Pravin T. P. Kaumaya

281. Hydrogen/Deuterium Exchange Studies on Helical Peptides in a DMSO/MeOD Solvent System
Erin Daly, Adam Blom, Matt Kubasik

282. Octapeptide Analogs of Somatostatin Containing a,a-Dialkylated Amino Acids with Potent Anticancer Activity
Sudhanand Prasad, Archna Mathur, Neena Gupta, Manu Jaggi, Anu T. Singh, Rama Mukherjee

283. Backbone Cyclization Improves the Enzymatic Stability of ?-Conotoxin, MrIA, whilst Maintaining its Structure and NET-Modulating Activity
Erica S. Lovelace, Christopher J. Armishaw, Michelle L. Colgrave, Paul F. Alewood, Norelle L. Daly, David J. Craik

284. De novo Design of Peptide Folds of Stereochemically Rationalized Molecular Architecture
Soumendra Rana, Bijoy Kundu, Susheel Durani

285. Restructuring Artificial Peptide Networks by External Triggering
Gonen Ashkenasy, M. Reza Ghadiri

286. Development of a Stilbene-type Photoswitchable ß-Hairpin Mimetic
Máté Erdélyi, Adolf Gogoll

287. The Guanidinium Group: A Key Player in Molecular Recognition
Ernest Giralt, Susana Gordo, Ignasi Belda, Silvia Pujals, Marc Martinell, Xavier Salvatella, Jimena Fernández-Carneado

288. Novel and Highly Selective Antagonist Scaffold for Human Melanocortin 3 Receptor: Computer-Aided Design and Biological Evaluation
Alexander V. Mayorov, Minying Cai, Kevin B. Chandler, Ravil R. Petrov, April R. Scoy, Zerui Yu, Dustin K. Tanaka, Dev Trivedi, Victor J. Hruby

289. Transmembrane Peptide Segments of the Uncoupling Protein-1: Chemical Synthesis and Biophysical Properties
Masoud Jelokhani-Niaraki, Marina Ivanova

290. Discovery and Optimization of ß-MSH Derived Melanocortin-4 Selective Agonists
John P. Mayer, Hansen M. Hsiung, David B. Flora, Patrick Edwards, Dennis P. Smith, Xing-Yue Zhang, Robert A. Gadski, Mark L. Heiman, JeAnne L. Hertel, Paul J. Emmerson, Saba Husain, Thomas P. O’Brien, Steven D. Kahl, David L. Smiley, Lianshan Zhang, Richard D. DiMarchi, Liang Zeng Yan

291. Molecular Mechanisms of Constitutive Activity: Mutations at Position 111 of the Angiotensin AT1 Receptor
Gregory V. Nikiforovich, Balász Mihalik, Kevin J. Catt, Garland R. Marshall

292. A Surprise End to 20 Year Search for Selective Agonists for Rat Vasopressin V1b Receptor
Maurice Manning, LingLing Cheng, Stoytcho B. Stoev, Nga C. Wo, Hazel H. Szeto, Ana Pena, Brigitte Murat, Miguel Trueba, Maria A. Ventura, Gilles Guillon

293. Furanoid Sugar Amino Acids in Design of Analogs of VIP Receptor Binding Inhibitor
Sudhanand Prasad, Archna Mathur, Manu Jaggi, Rajan Sharma, Neena Gupta, Rama Mukherjee, Ajit C. Kunwar, Tushar K. Chakraborty

294. Two Residues at the Extracellular Face of TM5 and TM6 Interact in the Active State of a G Protein-coupled Receptor
Yong-Hun Lee, Fred Naider, Jeffrey M. Becker

295. Molecular Probes for Visualizing Angiogenesis
Alan Cuthbertson, Grete Mørk Kindberg, Bård Indrevoll, Joseph Arukwe, Hege Karlsen, Alex Gibson, Julie Davis, Marivi Mendizabal, Matthew Morrison, Matthias Glaser

296. The Two Cysteine-rich Head Domains of Minicollagen from Hydra Nematocysts Differ in their Cystine Framework and Overall Fold despite an Identical Cysteine Sequence Pattern
Alexander G. Milb

Keywords: SCIENCE / Life Sciences / Biology / General SCI008000

Author(s)
Publisher
Springer
Publication year
2006
Language
en
Edition
1
Category
Natural Sciences
Format
Ebook
eISBN (PDF)
9780387265759

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